‘Dendrimer-Cationized-Albumin’ encrusted polymeric nanoparticle improves BBB penetration and anticancer activity of doxorubicin

Muniswamy, Vimalkumar Johnson; Raval, Nidhi; Gondaliya, Piyush; Tambe, Vishakha; Kalia, Kiran; Tekade, Rakesh K.

doi:10.1016/j.ijpharm.2018.11.035

Cited by 104 publications

(62 citation statements)

References 82 publications

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“…The hydrodynamic PS of MetNp were analyzed after subjecting samples to dynamic light scattering in Zetasizer Nano ZS 90 (Malvern instruments, Royston, UK) analogous to an earlier study performed by our group [ 16 , 26 , 27 , 28 ]. Samples were diluted (10-times) with deionized water at 25 ± 0.5 °C and were sonicated before examination.…”

Section: Methodsmentioning

confidence: 99%

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Sreeharsha

Rajpoot

Tekade³

et al. 2020

Pharmaceutics

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The aim of this study was to design, optimize, and develop metronidazole (Met) loaded nanoparticles (MetNp) by employing quality-based design (QbD) as well as a risk assessment methodology. A fractional factorial design was used by selecting five independent variables viz., chitosan concentration, tripolyphosphate concentration, and acetic acid concentration as material attributes, stirring speed, and stirring time as process parameters, whereby their influence on two dependent variables such as particle size (PS) and %entrapment efficiency (%EE) was studied. MetNp were synthesized by employing an ionic-gelation technique and optimized formula obtained from the QbD design study. PS and %EE studies revealed the formation of MetNp with 558.06 ± 2.52 nm and 59.07 ± 2.15%, respectively. Furthermore, a Met release study in various simulated gastro-intestinal media suggested pH-triggered (pH > 7.0) and sustained release profile of Met from Eudragit S100 enteric-coated MetNp capsule (MetNp cap). Moreover, the stability investigation of formulations confirmed good stability with respect to their PS and residual drug content (RDC) at different temperature conditions. In conclusion, the QbD method was effectively utilized in the development of MetNp and enteric-coated MetNp cap depicting their potential to release Met through MetNp cap only in the colon region and can be utilized for the treatment of amoebiasis in the colon.

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Section: Methodsmentioning

confidence: 99%

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Sreeharsha

Rajpoot

Tekade³

et al. 2020

Pharmaceutics

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“…Furthermore, the system was able to penetrate the blood-brain barrier (BBB) and blood tumour barrier (BTB). Cell experiments with U-87 MG glioblastoma cells showed a 5.5 fold increase in tumour cell death due to increasing the expression levels of caspase-3 gene which mediates cellular apoptosis [22].…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle Activation Methods in Cancer Treatment

2019

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In this review, we intend to highlight the progress which has been made in recent years around different types of smart activation nanosystems for cancer treatment. Conventional treatment methods, such as chemotherapy or radiotherapy, suffer from a lack of specific targeting and consequent off-target effects. This has led to the development of smart nanosystems which can effect specific regional and temporal activation. In this review, we will discuss the different methodologies which have been designed to permit activation at the tumour site. These can be divided into mechanisms which take advantage of the differences between healthy cells and cancer cells to trigger activation, and those which activate by a mechanism extrinsic to the cell or tumour environment.

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“…Figure 5 revealed that the apoptosis index of combination therapy (MPA-LNP + QC-LNP) is higher in comparison to alone LNPs, free drugs and their combination. The higher apoptosis index of LNPs as compared to free drugs and their combinations might be due to more cellular uptake (through clathrin-mediated) of LNPs and higher retention in the blood due to controlled release of drug for long time as mentioned in the drug release profile (Huang et al, 2019;Muniswamy et al, 2019). Moreover, the apoptosis index of combination therapy (MPA-LNP + QC-LNP) is also greater than the individual liposome formulation.…”

Section: Discussionmentioning

confidence: 99%

Liposomal Delivery of Mycophenolic Acid With Quercetin for Improved Breast Cancer Therapy in SD Rats

Patel

Thakur

Kushwah

et al. 2020

Front. Bioeng. Biotechnol.

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The present study explores the influence of mycophenolic acid (MPA) in combination therapy with quercetin (QC) (impeding MPA metabolic rate) delivered using the liposomal nanoparticles (LNPs). Mycophenolic acid liposome nanoparticles (MPA-LNPs) and quercetin liposome nanoparticles (QC-LNPs) were individually prepared and comprehensively characterized. The size of prepared MPA-LNPs and QC-LNPs were found to be 183 ± 13 and 157 ± 09.8, respectively. The in vitro studies revealed the higher cellular uptake and cytotoxicity of combined therapy (MPA-LNPs + QC-LNPs) compared to individual ones. Moreover pharmacokinetics studies in female SD-rat shown higher T 1/2 value (1.94 fold) of combined therapy compared to MPA. Furthermore, in vivo anticancer activity in combination of MPA-LNPs and QC-LNPs was also significantly higher related to other treatments groups. The combination therapy of liposomes revealed the new therapeutic approach for the treatment of breast cancer.

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‘Dendrimer-Cationized-Albumin’ encrusted polymeric nanoparticle improves BBB penetration and anticancer activity of doxorubicin

Cited by 104 publications

References 82 publications

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Development of Metronidazole Loaded Chitosan Nanoparticles Using QbD Approach—A Novel and Potential Antibacterial Formulation

Nanoparticle Activation Methods in Cancer Treatment

Liposomal Delivery of Mycophenolic Acid With Quercetin for Improved Breast Cancer Therapy in SD Rats

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