Dendrimer-based nanoparticles for potential personalized therapy in chronic lymphocytic leukemia: Targeting the BCR-signaling pathway

Franiak-Pietryga, Ida; Maciejewski, Henryk; Ostrowska, Kinga; Appelhans, Dietmar; Voit, Brigitte; Misiewicz, Małgorzata; Kowalczyk, Paweł; Bryszewska, Maria; Borowiec, Maciej

doi:10.1016/j.ijbiomac.2016.03.021

Cited by 16 publications

(4 citation statements)

References 33 publications

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“…The present work is part of a series of publications describing the effect of PPI glycodendrimers on signaling pathway gene expression in CLL cells. The results of microarray analysis for BCR, TRAIL and WNT have already been published (Franiak-Pietryga et al, 2017a;Franiak-Pietryga et al, 2017c;Franiak-Pietryga et al, 2016) and they indicate that glycodendrimers significantly modulate expression of the examined genes thereby reducing the CLL cells survival. Findings of these preliminary results might be of an importance considering the usage of PPI dendrimers as active compounds in the future.…”

Section: Introductionmentioning

confidence: 94%

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Affecting NF-κB cell signaling pathway in chronic lymphocytic leukemia by dendrimers-based nanoparticles

Franiak-Pietryga

Ostrowska

Maciejewski

et al. 2018

Toxicology and Applied Pharmacology

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The complex genetic diversity of chronic lymphocytic leukemia (CLL) makes it difficult to determine the effective and durable therapy beneficial to patients. During the several past years' significant insights in the biology of the disease and its treatment have been made, allowing for the identification of promising novel therapeutic agents. The investigation of signaling pathways to understand the biological character of CLL together with the development of molecular profiling is key in personalized approach in therapy for this disease. As it was already proven, maltotriose (M3) modified fourth generation poly(propylene imine) dendrimers (PPI-G4) modulate BCR, TRAIL and WNT signaling pathway gene expression in CLL cells and strongly influence their survival by inducing apoptosis and inhibiting proliferation. The aim of this study was to evaluate the influence of PPI-G4-M3 dendrimers on NFκB pathway gene expression in CLL (MEC-1) cells with 60 K microarray, as it is one of the major factors in the pathogenesis of B-cell neoplasms. The findings were compared with those obtained with Fludarabine (FA) and the results indicate that PPI-G4-M3 dendrimers affect the expression of the examined genes and exert comparable effect on the CLL cells to FA. Dendrimers are one of the most potent groups of nanometer-sized macromolecules for closing the gap between the present ineffective treatment and the future effective personalized therapy due to their potential versatile biological properties.

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Section: Introductionmentioning

confidence: 94%

“…ACC 497) was used. Cells were treated as described in previous papers (Franiak-Pietryga et al, 2017b;Franiak-Pietryga et al, 2017c;Franiak-Pietryga et al, 2016). For the treatment cells were incubated with either FA (1.6 μM) or GD (8 mg/mL), up to 4 h. Cultures without GD or FA were used as reference (Ref).…”

Section: Cell Culture and Treatmentmentioning

confidence: 99%

Affecting NF-κB cell signaling pathway in chronic lymphocytic leukemia by dendrimers-based nanoparticles

Franiak-Pietryga

Ostrowska

Maciejewski

et al. 2018

Toxicology and Applied Pharmacology

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“…Lactic acid incorporation on Doxorubicin-loading PLL was proved to assist the targeting to liver tissue. Through the interaction of JL1, leukemia cells were proved to be targeted [82][83][84].…”

Section: Poly-l-lysine (Pll)mentioning

confidence: 99%

Layer-by-Layer Cell Encapsulation for Drug Delivery: The History, Technique Basis, and Applications

Lei

Feng

et al. 2022

Pharmaceutics

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The encapsulation of cells with various polyelectrolytes through layer-by-layer (LbL) has become a popular strategy in cellular function engineering. The technique sprang up in 1990s and obtained tremendous advances in multi-functionalized encapsulation of cells in recent years. This review comprehensively summarized the basis and applications in drug delivery by means of LbL cell encapsulation. To begin with, the concept and brief history of LbL and LbL cell encapsulation were introduced. Next, diverse types of materials, including naturally extracted and chemically synthesized, were exhibited, followed by a complicated basis of LbL assembly, such as interactions within multilayers, charge distribution, and films morphology. Furthermore, the review focused on the protective effects against adverse factors, and bioactive payloads incorporation could be realized via LbL cell encapsulation. Additionally, the payload delivery from cell encapsulation system could be adjusted by environment, redox, biological processes, and functional linkers to release payloads in controlled manners. In short, drug delivery via LbL cell encapsulation, which takes advantage of both cell grafts and drug activities, will be of great importance in basic research of cell science and biotherapy for various diseases.

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“…Moreover, sugar-modified PPI dendrimers tested by our research team at University of Lodz, Poland, are very attractive and specific for leukemia and lymphoma cells derived from lymphocytes B. Depending on the sugar on the surface and the number of molecules, we can observe the different extend of triggering apoptosis in those cells due to the diversity in affecting particular gene pathways [48][49][50][51]. Lysine dendrimers, PAMAM, PPI, and phosphorus have been reported to be able to modulate amyloid peptide aggregation in solution [52][53][54].…”

Section: Dendrimers As Drug Delivery Systemsmentioning

confidence: 99%

Dendrimers as Drug Nanocarriers: The Future of Gene Therapy and Targeted Therapies in Cancer

Franiak-Pietryga¹,

Ziemba²,

Messmer³

et al. 2018

Dendrimers - Fundamentals and Applications

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Synthetic polymers, such as dendrimers, play a critical role in pharmaceutical discovery and development. Advances in the application of nanotechnology in medicine have given rise to multifunctional "smart" nanocarriers that can deliver one or more therapeutic agents safely and selectively to cancer cells, including intracellular gene-specific targeting. Dendrimers with their 3D nanopolymeric architectures are highly attractive class of drug and gene delivery vector. Advances in understanding and manipulating genes gave scientists a tool to make changes in people DNA to prevent or treat diseases. Over the past decade, gene therapy has been in use in clinical trials. The inactivation of the tumor suppressor genes is the main idea of the development of gene therapy in the cancer treatment. Broad spectrum of delivery concepts, including viral vectors, liposomes, cationic polymers and dendrimers, cell-penetrating peptides and gold and magnetic nanoparticles have been investigated. A well-designed vector is the most desirable approach to increase the safety of gene therapy, which is still in its infancy stages in cancer research. More experimental and clinical trials are focused on well-designed and effective doses of vectors that are essential for therapeutic efficacy of gene therapy for its potential in clinical use against a wide variety of cancers.

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Dendrimer-based nanoparticles for potential personalized therapy in chronic lymphocytic leukemia: Targeting the BCR-signaling pathway

Cited by 16 publications

References 33 publications

Affecting NF-κB cell signaling pathway in chronic lymphocytic leukemia by dendrimers-based nanoparticles

Affecting NF-κB cell signaling pathway in chronic lymphocytic leukemia by dendrimers-based nanoparticles

Layer-by-Layer Cell Encapsulation for Drug Delivery: The History, Technique Basis, and Applications

Dendrimers as Drug Nanocarriers: The Future of Gene Therapy and Targeted Therapies in Cancer

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