Dendrimer-based nanocomposites for the production of RNA delivery systems

Lim, Chiou Chyi; Chia, Le Yi; Kumar, Palanirajan Vijayaraj

doi:10.1016/j.onano.2023.100173

Cited by 3 publications

(1 citation statement)

References 115 publications

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“…Dendrimers have emerged as a significant sector in healthcare due to their ideal properties of having very strong drug delivery potential, making them good carriers. Dendrimer-based nanoparticles have a strategic role in the targeted administration of miRNAs in cancer therapy because they can transport large numbers of TNA (Therapeutic Nucleic Acids) into both cells and target tissues [210,211]. The main advantage that distinguishes dendrimers is their monodispersity because they are all identical and have a well-defined size after synthesis compared to other polymeric compounds that are produced by uncontrolled polymerization [212,213].…”

Section: Polymeric Nanoparticlesmentioning

confidence: 99%

miRNA-Based Technologies in Cancer Therapy

Pagoni,

Cava,

Sideris

et al. 2023

JPM

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The discovery of therapeutic miRNAs is one of the most exciting challenges for pharmaceutical companies. Since the first miRNA was discovered in 1993, our knowledge of miRNA biology has grown considerably. Many studies have demonstrated that miRNA expression is dysregulated in many diseases, making them appealing tools for novel therapeutic approaches. This review aims to discuss miRNA biogenesis and function, as well as highlight strategies for delivering miRNA agents, presenting viral, non-viral, and exosomic delivery as therapeutic approaches for different cancer types. We also consider the therapeutic role of microRNA-mediated drug repurposing in cancer therapy.

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Section: Polymeric Nanoparticlesmentioning

confidence: 99%

miRNA-Based Technologies in Cancer Therapy

Pagoni,

Cava,

Sideris

et al. 2023

JPM

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Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds

Zhang,

Ding

et al. 2024

Small

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Although bioactive compounds (BCs) have many important functions, their applications are greatly limited due to their own defects. The development of nanocarriers (NCs) technology has gradually overcome the defects of BCs. NCs are equally important as BCs to some extent. Self‐assembly (SA) methods to build NCs have many advantages than chemical methods, and SA has significant impact on the structure and function of NCs. However, the relationship among SA mechanism, structure, and function has not been given enough attention. Therefore, from the perspective of bottom‐up building mechanism, the concept of SA‐structure‐function of NCs is emphasized to promote the development of SA‐based NCs. First, the conditions and forces for occurring SA are introduced, and then the SA basis and molecular mechanism of protein, polysaccharide, and lipid are summarized. Then, varieties of the structures formed based on SA are introduced in detail. Finally, facing the defects of BCs and how to be well solved by NCs are also elaborated. This review attempts to describe the great significance of constructing artificial NCs to deliver BCs from the aspects of SA‐structure‐function, so as to promote the development of SA‐based NCs and the wide application of BCs.

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Bio-Inspired Nanomaterials for Micro/Nanodevices: A New Era in Biomedical Applications

Harun-Ur-Rashid,

Jahan,

Foyez

et al. 2023

Micromachines

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Exploring bio-inspired nanomaterials (BINMs) and incorporating them into micro/nanodevices represent a significant development in biomedical applications. Nanomaterials, engineered to imitate biological structures and processes, exhibit distinctive attributes such as exceptional biocompatibility, multifunctionality, and unparalleled versatility. The utilization of BINMs demonstrates significant potential in diverse domains of biomedical micro/nanodevices, encompassing biosensors, targeted drug delivery systems, and advanced tissue engineering constructs. This article thoroughly examines the development and distinctive attributes of various BINMs, including those originating from proteins, DNA, and biomimetic polymers. Significant attention is directed toward incorporating these entities into micro/nanodevices and the subsequent biomedical ramifications that arise. This review explores biomimicry’s structure–function correlations. Synthesis mosaics include bioprocesses, biomolecules, and natural structures. These nanomaterials’ interfaces use biomimetic functionalization and geometric adaptations, transforming drug delivery, nanobiosensing, bio-inspired organ-on-chip systems, cancer-on-chip models, wound healing dressing mats, and antimicrobial surfaces. It provides an in-depth analysis of the existing challenges and proposes prospective strategies to improve the efficiency, performance, and reliability of these devices. Furthermore, this study offers a forward-thinking viewpoint highlighting potential avenues for future exploration and advancement. The objective is to effectively utilize and maximize the application of BINMs in the progression of biomedical micro/nanodevices, thereby propelling this rapidly developing field toward its promising future.

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Dendrimer-based nanocomposites for the production of RNA delivery systems

Cited by 3 publications

References 115 publications

miRNA-Based Technologies in Cancer Therapy

miRNA-Based Technologies in Cancer Therapy

Self‐Assembled Nanocarrier Delivery Systems for Bioactive Compounds

Bio-Inspired Nanomaterials for Micro/Nanodevices: A New Era in Biomedical Applications

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