Dence for a gene in rats affecting lymphocyte responsiveness to PHA

Gasser, David L.; Winters, Bart; Balaban-Malenbaum, Gloria

doi:10.1007/bf01844000

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…The defective response of BN spleen cells was observed equally with MAS, PHA, and Con A. Such a defect has been described previously by several groups [8,[15][16][17][18], but different explanations were offered. One group reported that BN rats had an immunogenetic defect of T lymphocytes' response to mitogens [8].…”

Section: Discussionsupporting

confidence: 61%

“…Such a defect has been described previously by several groups [8,[15][16][17][18], but different explanations were offered. One group reported that BN rats had an immunogenetic defect of T lymphocytes' response to mitogens [8]. Others have reported that suppressor macrophages are present in the spleens of BN rats capable of depressing T-cell responses to the mitogens [17].…”

Section: Discussionmentioning

confidence: 71%

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Lymphoproliferative Responses of Spleen Cells of Inbred Rat Strains to Mycoplasma arthritidis Mitogen

et al. 1984

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A potent mitogen for T lymphocytes of various species has recently been isolated from the supernatant of cultured Mycoplasma arthritidis organisms (MAS). In the mouse, reactivity to this mitogen has been observed to be controlled by the I-E subregion of the major histocompatibility complex. We have analysed the responses of spleen cells from several inbred rat strains covering practically all known haplotypes of the major histocompatibility complex of the rat (RT1). Unlike in the mouse, all of these responded well to MAS, except for the BN rat strain, which is a low responder to all T-cell mitogens, including phytohaemagglutinin and concanavalin A. This unresponsiveness, however, appeared to be unrelated to the RT1 haplotype, since LEW.1N rats carrying the same RT1n haplotype as BN animals responded well. Mice of the strain C57BL/6 are non-responders to MAS, but--as previously shown--their spleen cell responses can be reconstituted by the addition of 2-mercaptoethanol. No such reconstitution was observed for the low responsiveness of BN rat spleen cells. Stimulation with MAS induced high titres of interferon (presumably gamma interferon) in spleen cells from all rat strains tested. Spleen cells from BN rats produced lower interferon activities than those from other strains.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 71%

Lymphoproliferative Responses of Spleen Cells of Inbred Rat Strains to Mycoplasma arthritidis Mitogen

et al. 1984

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“…However, because this association is unlikely to reflect a direct involvement of MHC molecules in the physiological processes elicited by PHA (Licastro et al 1993;Bonneaud et al 2005), the pattern we detected here could also result if other genes have stronger effects on this trait. In accordance with this hypothesis, responsiveness to PHA has been found to involve genes that are not tightly linked to the Mhc (Gasser et al 1978;Morrow & Abplanalp 1981).…”

Section: Discussionmentioning

confidence: 71%

Mhcpolymorphisms fail to explain the heritability of phytohaemagglutinin-induced skin swelling in a wild passerine

et al. 2009

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Genetic estimates of the variability of immune responses are rarely examined in natural populations because of confounding environmental effects. As a result, and because of the difficulty of pinpointing the genetic determinants of immunity, no study has to our knowledge examined the contribution of specific genes to the heritability of an immune response in wild populations. We cross-fostered nestling house sparrows to disrupt the association between genetic and environmental effects and determine the heritability of the response to a classic immunological test, the phytohaemagglutinin (PHA)-induced skin swelling. We detected significant heritability estimates of the response to PHA, of body mass and tarsus length when nestlings were 5 and 10 days old. Variation at Mhc genes, however, did not explain a significant portion of the genetic variation of nestling swelling to PHA. Our results suggest that while PHA-induced swelling is influenced by the nest of origin, the importance of additive genetic variation relative to non-additive genetic variation and the genetic factors that influence the former in wild populations still need to be identified for this trait.

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“…Immune responses will strongly influence the growth of virus-induced tumors in mice and rats (Chesebro and Wehrly, 1976a, b ;Gorczynski, 1974;Jones et al, 1977;Steeves and Lilly, 1977). In rats as in mice, antibody and cellular responses are usually regulated by genes linked to the major histocompatibility (RT-1 in rats) complex (Albright et al, 1977;Kunz et al, 1974;Stuffer-Heiman et al, 1979); but in some cases, background genes not linked to RT-1 influenced the level of the response or were required for it to occur (Jones et al, 1982;Gasser et al, 1978;Gunther et al, 1978;Gill et al, 1970). Bone marrow chimeras and athymic animals have been useful in the characterization of the cellular and genetic basis of immune responses (Singer, A. et al, 1981;Singer, D. et al, 1981;Erb et al, 1980;von Boehmer et al, 1978).…”

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confidence: 99%

Genetic control of immune responses to moloney sarcomas in rats: Role of non‐RT‐1 background genes

Jones

1983

Intl Journal of Cancer

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Bone marrow chimeras, athymic nude rats and a congeneic strain were utilized to verify and further examine non-RT-1 linked background genes that influence immune responses of BN and LEW rats to Moloney sarcomas. In transplants that did not involve RT-1 incompatibility, infusion of high-responder bone marrow into a lethally irradiated low-responder recipient, or low-responder bone marrow into a high-responder recipient, would restore a high antibody response to the gp70 antigen of MuLV. Such transplants did not restore a high response to the p30 antigen. Athymic nude rats did not exhibit a significant response to either p30 or gp70 while euthymic littermates exhibited a significant response to both antigens. Growth of Moloney sarcomas as well as antibody and cellular responses to antigens expressed by such tumors were measured in LEW-IN rats which carry the RT-1 of BN and the background of LEW. For each of these parameters, LEW-IN resembled LEW more closely than BN.

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Dence for a gene in rats affecting lymphocyte responsiveness to PHA

Cited by 4 publications

References 8 publications

Lymphoproliferative Responses of Spleen Cells of Inbred Rat Strains to Mycoplasma arthritidis Mitogen

Lymphoproliferative Responses of Spleen Cells of Inbred Rat Strains to Mycoplasma arthritidis Mitogen

Mhcpolymorphisms fail to explain the heritability of phytohaemagglutinin-induced skin swelling in a wild passerine

Genetic control of immune responses to moloney sarcomas in rats: Role of non‐RT‐1 background genes

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