Denaturing high‐performance liquid chromatography and principal component analysis for identification of DNA point mutations in breast cancer and lymphoma samples
Abstract:DNA mutations are identified by techniques that use the knowledge of the wild‐type DNA sequence and its mutated variant. The involved analytic methods must be accurate, rapid, and sustainable, if a clinical application is pursued. High‐performance liquid chromatography under denaturing conditions is a useful technique to screen mutations. Denaturing high‐performance liquid chromatography resultant chromatograms are suitable for feature extraction analysis with multivariate methods such as principal component a… Show more
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