Abstract:The initiation of asymmetric karyokinesis of intraerythrocytic Plasmodium falciparum (Pf) begins with- out dismantling the nuclear envelope showing the hallmark feature of closed mitosis (1-10). In Pf, karyokinesis precedes cytokinesis and cell body formation (6, 8-10). Regulation at the beginning of nu- clear division either through checkpoints or by importing serum components was largely unknown. At the trophozoite stage, PfP2 tetramer trafficked to the infected erythrocyte (IE) surface and the inacces- sibi… Show more
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