Biophoton emission is produced by all living systems; this emission pattern has been shown to be altered by the presence of an electromagnetic field (EMF). Cultures of B16-BL6 cells were exposed to a weak EMF produced by a specially constructed EM generator, called the "Resonator", for one hour. This EM generator incorporates multiple geometric ratios in its design, including the golden ratio (phi), pi, root 2, root 3, and root 5. It has been used previously to purify water of toxins. There was a significant decrease in mean photon counts from B16-BL6 cells exposed at a distance of 1 m compared to those exposed at 0 m. Alterations in the spectral power density variability were also observed in the 8-10 Hz range. The EM generator may have an impact on the viability of the exposed cell cultures, but only at specific distances.