Demyelination of superficial white matter in early Alzheimer's disease: a magnetization transfer imaging study

Fornari, Eleonora; Maeder, Philippe; Meuli, Reto; Ghika, Joseph; Knyazeva, Maria G.

doi:10.1016/j.neurobiolaging.2010.11.014

Cited by 60 publications

(64 citation statements)

References 70 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aberrant short-range connections have also been observed in other brain disorders such as Alzheimer’s disease (e.g. Carmeli et al , 2014; Fornari et al , 2012; Phillips et al , 2016a), tuberous sclerosis complex (e.g. Im et al, 2015), Huntington’s disease (e.g.…”

Section: Atypical Development Of Short-range Connectivity In Humanmentioning

confidence: 99%

Short-range connections in the developmental connectome during typical and atypical brain maturation

Ouyang

Kang

Detre

et al. 2017

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

The human brain is remarkably complex with connectivity constituting its basic organizing principle. Although long-range connectivity has been focused on in most research, short-range connectivity is characterized by unique and spatiotemporally heterogeneous dynamics from infancy to adulthood. Alterations in the maturational dynamics of short-range connectivity has been associated with neuropsychiatric disorders, such as autism and schizophrenia. Recent advances in neuroimaging techniques, especially diffusion magnetic resonance imaging (dMRI), resting-state functional MRI (rs-fMRI), electroencephalography (EEG) and magnetoencephalography (MEG), have made quantification of short-range connectivity possible in pediatric populations. This review summarizes findings on the development of short-range functional and structural connections at the macroscale. These findings suggest an inverted U-shaped pattern of maturation from primary to higher-order brain regions, and possible “hyper-” and “hypo-” short-range connections in autism and schizophrenia, respectively. The precisely balanced short- and long-range connections contribute to the integration and segregation of the connectome during development. The mechanistic relationship among short-range connectivity maturation, the developmental connectome and emerging brain functions needs further investigation, including the refinement of methodological approaches.

show abstract

Section: Atypical Development Of Short-range Connectivity In Humanmentioning

confidence: 99%

Short-range connections in the developmental connectome during typical and atypical brain maturation

Ouyang

Kang

Detre

et al. 2017

Neuroscience & Biobehavioral Reviews

View full text Add to dashboard Cite

show abstract

“…Demyelination of the superficial WM (Fornari et al, 2012) and disrupted axons within WM (Skillback et al, 2013) may lay the foundation for WM deficits observed in AD. Age-related WM hypoperfusion may lead to WM ischemia and subsequent WM damage, which may also underlie WM disruptions in AD.…”

Section: Aging Of White Matter In Neurodegenerative Diseasesmentioning

confidence: 99%

Aging of cerebral white matter

Liu

Yang

Xia

et al. 2017

Ageing Research Reviews

197

141

View full text Add to dashboard Cite

White matter (WM) occupies a large volume of the human cerebrum and is mainly composed of myelinated axons and myelin-producing glial cells. The myelinated axons within WM are the structural foundation for efficient neurotransmission between cortical and subcortical areas. Similar to neuron-enriched gray matter areas, WM undergoes a series of changes during the process of aging. WM malfunction can induce serious neurobehavioral and cognitive impairments. Thus, age-related changes in WM may contribute to the functional decline observed in the elderly. In addition, aged WM becomes more susceptible to neurological disorders, such as stroke, traumatic brain injury (TBI), and neurodegeneration. In this review, we summarize the structural and functional alterations of WM in natural aging and speculate on the underlying mechanisms. We also discuss how age-related WM changes influence the progression of various brain disorders, including ischemic and hemorrhagic stroke, TBI, Alzheimer’s disease, and Parkinson’s disease. Although the physiology of WM is still poorly understood relative to gray matter, WM is a rational therapeutic target for a number of neurological and psychiatric conditions.

show abstract

“…A postmortem study of the multiple sclerosis brain demonstrated highly significant correlations between morphometric and MTI measures of myelin content [41]. Since the most important contributors to the magnetization transfer effect are the extent, concentration, and integrity of myelin membranes, MTI permits an accurate evaluation of changes in myelination in children, aging people, and populations with myelination abnormalities [42–44]. Consistently with previously reviewed reports, in a group of healthy children, the most robust direct correlation between the MTI index of myelination and a child's age has been shown by Fornari and colleagues for the area of the splenium [38].…”

Section: Structural Development Of the Spleniummentioning

confidence: 99%

Splenium of Corpus Callosum: Patterns of Interhemispheric Interaction in Children and Adults

Knyazeva

2013

Neural Plasticity

Self Cite

101

View full text Add to dashboard Cite

The splenium of the corpus callosum connects the posterior cortices with fibers varying in size from thin late-myelinating axons in the anterior part, predominantly connecting parietal and temporal areas, to thick early-myelinating fibers in the posterior part, linking primary and secondary visual areas. In the adult human brain, the function of the splenium in a given area is defined by the specialization of the area and implemented via excitation and/or suppression of the contralateral homotopic and heterotopic areas at the same or different level of visual hierarchy. These mechanisms are facilitated by interhemispheric synchronization of oscillatory activity, also supported by the splenium. In postnatal ontogenesis, structural MRI reveals a protracted formation of the splenium during the first two decades of human life. In doing so, the slow myelination of the splenium correlates with the formation of interhemispheric excitatory influences in the extrastriate areas and the EEG synchronization, while the gradual increase of inhibitory effects in the striate cortex is linked to the local inhibitory circuitry. Reshaping interactions between interhemispherically distributed networks under various perceptual contexts allows sparsification of responses to superfluous information from the visual environment, leading to a reduction of metabolic and structural redundancy in a child's brain.

show abstract

Demyelination of superficial white matter in early Alzheimer's disease: a magnetization transfer imaging study

Cited by 60 publications

References 70 publications

Short-range connections in the developmental connectome during typical and atypical brain maturation

Short-range connections in the developmental connectome during typical and atypical brain maturation

Aging of cerebral white matter

Splenium of Corpus Callosum: Patterns of Interhemispheric Interaction in Children and Adults

Contact Info

Product

Resources

About