DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia

Kalbe, Elke; Kessler, Josef; Calabrese, Pasquale; Smith, Renee L.; Passmore, A. Peter; Brand, Matthias; Bullock, Roger

doi:10.1002/gps.1042

Cited by 667 publications

(502 citation statements)

References 35 publications

(29 reference statements)

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“…The pen-and-paper tests currently used in clinical practice not only help clinicians differentiate between normal cognition, MCI and dementia, 45,46,48 but also assist in staging severity of illness. In contrast, CANTAB was the only automated test in this review that could stage severity.…”

Section: Applicability Of Findings To the Review Questionmentioning

confidence: 99%

Automated tests for diagnosing and monitoring cognitive impairment: a diagnostic accuracy review

Aslam

Bates

Dündar

et al. 2016

Health Technol Assess

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BackgroundCognitive impairment is a growing public health concern, and is one of the most distinctive characteristics of all dementias. The timely recognition of dementia syndromes can be beneficial, as some causes of dementia are treatable and are fully or partially reversible. Several automated cognitive assessment tools for assessing mild cognitive impairment (MCI) and early dementia are now available. Proponents of these tests cite as benefits the tests’ repeatability and robustness and the saving of clinicians’ time. However, the use of these tools to diagnose and/or monitor progressive cognitive impairment or response to treatment has not yet been evaluated.ObjectivesThe aim of this review was to determine whether or not automated computerised tests could accurately identify patients with progressive cognitive impairment in MCI and dementia and, if so, to investigate their role in monitoring disease progression and/or response to treatment.Data sourcesFive electronic databases (MEDLINE, EMBASE, The Cochrane Library, ISI Web of Science and PsycINFO), plus ProQuest, were searched from 2005 to August 2015. The bibliographies of retrieved citations were also examined. Trial and research registers were searched for ongoing studies and reviews. A second search was run to identify individual test costs and acquisition costs for the various tools identified in the review.Review methodsTwo reviewers independently screened all titles and abstracts to identify potentially relevant studies for inclusion in the review. Full-text copies were assessed independently by two reviewers. Data were extracted and assessed for risk of bias by one reviewer and independently checked for accuracy by a second. The results of the data extraction and quality assessment for each study are presented in structured tables and as a narrative summary.ResultsThe electronic searching of databases, including ProQuest, resulted in 13,542 unique citations. The titles and abstracts of these were screened and 399 articles were shortlisted for full-text assessment. Sixteen studies were included in the diagnostic accuracy review. No studies were eligible for inclusion in the review of tools for monitoring progressive disease. Eleven automated computerised tests were assessed in the 16 included studies. The overall quality of the studies was good; however, the wide range of tests assessed and the non-standardised reporting of diagnostic accuracy outcomes meant that meaningful synthesis or statistical analysis was not possible.LimitationsThe main limitation of this review is the substantial heterogeneity of the tests assessed in the included studies. As a result, no meta-analyses could be undertaken.ConclusionThe quantity of information available is insufficient to be able to make recommendations on the clinical use of the computerised tests for diagnosing and monitoring MCI and early dementia progression. The value of these tests also depends on the costs of acquisition, training, administration and scoring.Future workResearch is required to establish stable cut-off points for automated computerised tests that are used to diagnose patients with MCI or early dementia. Additionally, the costs associated with acquiring and using these tests in clinical practice should be estimated.Study registrationThe study is registered as PROSPERO CRD42015025410.FundingThe National Institute for Health Research Health Technology Assessment programme.

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Section: Applicability Of Findings To the Review Questionmentioning

confidence: 99%

Automated tests for diagnosing and monitoring cognitive impairment: a diagnostic accuracy review

Aslam

Bates

Dündar

et al. 2016

Health Technol Assess

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“…For those older than 40 years, the DemTect questionnaire [14] was administered to detect any mild cognitive impairment and participants were required to score ≥ 13 (indicative of age-appropriate cognitive abilities) for inclusion. The eligibility criteria are described in Table 1.…”

Section: Recruitment and Screeningmentioning

confidence: 99%

A randomised trial comparing low-fat diets differing in carbohydrate and protein ratio, combined with regular moderate intensity exercise, on glycaemic control, cardiometabolic risk factors, food cravings, cognitive function and psychological wellbeing in adults with type 2 diabetes: Study protocol

Watson

Dyer

Buckley

et al. 2015

Contemporary Clinical Trials

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“…One year after commencement of the study, the DemTect cognition screen (Kalbe et al, 2004) was added to the cognition test battery, and the order of administration of the cognition tests within the test battery was randomized for participants in order to adjust for potential fatigue effects and confounding from administration of multiple cognition screens.…”

Section: Assessmentmentioning

confidence: 99%

Protocol for Candrive II/Ozcandrive, a multicentre prospective older driver cohort study

Marshall

Man-Son-Hing

Bedard

et al. 2013

Accident Analysis & Prevention

106

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DemTect: a new, sensitive cognitive screening test to support the diagnosis of mild cognitive impairment and early dementia

Cited by 667 publications

References 35 publications

Automated tests for diagnosing and monitoring cognitive impairment: a diagnostic accuracy review

Automated tests for diagnosing and monitoring cognitive impairment: a diagnostic accuracy review

A randomised trial comparing low-fat diets differing in carbohydrate and protein ratio, combined with regular moderate intensity exercise, on glycaemic control, cardiometabolic risk factors, food cravings, cognitive function and psychological wellbeing in adults with type 2 diabetes: Study protocol

Protocol for Candrive II/Ozcandrive, a multicentre prospective older driver cohort study

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