Demonstration program of population‐based lung cancer screening in <scp>C</scp>hina: Rationale and study design

Zhou, Qinghua; Fan, Yaguang; Wu, Ning; Huang, Yunchao; Wang, Ying; Li, Lu; Liu, Jiewei; Wang, Xinyun; Liu, Weimin; Qiao, You‐Lin

doi:10.1111/1759-7714.12078

Cited by 39 publications

(50 citation statements)

References 30 publications

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“…These studies were mainly carried out in several economically developed urban areas or high‐risk rural areas in China, such as Beijing, Tianjin, and Xuanwei of Yunnan provinces. The number of participants in these studies ranged from a few hundred to more than 5000 …”

Section: Ldct Lung Cancer Screening In Chinamentioning

confidence: 99%

“…Recently, several large‐scale lung cancer screening programs have been initiated with special funds from central or local governments in China. In 2010, a national demonstration program was initiated with a special fund from the Chinese Central Government Public Health Special Subsidy, focusing on screening projects on lung, upper digestive tract, colorectal, liver, and nasopharyngeal cancers in rural areas of China . A lung cancer screening project was undertaken using LDCT in three regions that have a high incidence and mortality from lung cancer: Xuanwei city in Yunnan province, Dagang Oilfield in Tianjin, and Haidian District in Beijing.…”

Section: Ldct Lung Cancer Screening In Chinamentioning

confidence: 99%

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Early detection of lung cancer: Low‐dose computed tomography screening in China

Zhao

2015

Thoracic Cancer

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Lung cancer is currently the leading cause of cancer-related death in China and western countries for both men and women. Overall, the five-year survival rate of lung cancer is approximately 15%, whereas the five-year survival for patients with surgically resected early-stage disease is 60–80%. Screening is conceptually a good strategy for reducing the mortality rate of lung cancer. Randomized controlled trials in the 1960s and 1970s found that chest radiographic screening did not result in a reduction in mortality for high-risk individuals. Recently published data from the National Lung Screening Trial (NLST) showed a 20% reduction in lung cancer mortality in subjects who underwent low-dose computed tomography (LDCT) screening compared to those randomized to conventional chest X-ray. The encouraging results of the NLST, however, could not be confirmed by the preliminary results of ongoing European trials. More results from European randomized controlled trials are expected in the next few years. Recently, a number of lung cancer screening studies using LDCT have been initiated in China. This article briefly summarizes the results of the current and previous lung cancer screening trials worldwide, and focuses on the current status of LDCT lung cancer screening in China.

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Section: Ldct Lung Cancer Screening In Chinamentioning

confidence: 99%

Section: Ldct Lung Cancer Screening In Chinamentioning

confidence: 99%

Early detection of lung cancer: Low‐dose computed tomography screening in China

Zhao

2015

Thoracic Cancer

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“…In recent years, low-dose spiral computed tomography (LDCT) has shown promising results, and related guidelines for screening have been developed in the United States (85,86). A demonstration program of population-based lung cancer screening was initiated in China (87), and it will provide opportunities to explore the feasibility of LDCT lung cancer screening in the Chinese setting.…”

Section: Lung Cancer Preventionmentioning

confidence: 99%

Cancer Prevention Research in China

Yang

et al. 2015

Cancer Prevention Research

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“…Since 2013, lung cancer screening has been recommended by the United States Preventive Services Task Force . Based on this context, some programs have been carried out to assess the performance of lung cancer screening with LDCT in China . However, the performance of population‐based lung cancer screening with LDCT in China is uncertain.…”

Section: Introductionmentioning

confidence: 99%

“…Since 2009, the Lung Cancer Screening Program in Rural China (LungSPRC) has been included in the cancer early detection and treatment program, a special funded program supported by the Chinese Central Government Public Health Special Subsidy . Gejiu, a small city in Yunnan Province and the site of the largest Asian tin industry, has been reported to have the highest male lung cancer mortality among all Chinese areas, as described in a 1973 nationwide survey .…”

Section: Introductionmentioning

confidence: 99%

Performance of lung cancer screening with low‐dose CT in Gejiu, Yunnan: A population‐based, screening cohort study

Wei

Wang³

et al. 2020

Thoracic Cancer

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Background: The performance of lung cancer screening with low-dose computed tomography (CT) (LDCT) in China is uncertain. This study aimed to evaluate the performance of LDCT lung cancer screening in the Chinese setting. Methods: In 2014, a screening cohort of lung cancer with LDCT was established in Gejiu, Yunnan Province, a screening center of the Lung Cancer Screening Program in Rural China (LungSPRC). Participants received a baseline screening and four rounds of annual screening with LDCT in two local hospitals until June 2019. We analyzed the rates of participation, detection, early detection, and the clinical characteristics of lung cancer. Results: A total of 2006 participants had complete baseline screening results with a compliance rate of 98.4%. Of these, 1411 were high-risk and 558 were nonhigh-risk participants. During this period, 40 lung cancer cases were confirmed, of these, 35 were screen-detected, four were post-screening and one was an interval case. The positive rate of baseline and annual screening was 9.7% and 9.0%, while the lung cancer detection rate was 0.4% and 0.6%, respectively. The proportion of early lung cancer increased from 37.5% in T0 to 75.0% in T4. Adenocarcinoma was the most common histological subtype. Lung cancer incidence according to the criteria of LungSPRC and National Lung Cancer Screening Trial (NLST) was 513.31 and 877.41 per 100 000 person-years, respectively. Conclusions: The program of lung cancer screening with LDCT showed a successful performance in Gejiu, Yunnan. However, further studies are warranted to refine a high-risk population who will benefit most from LDCT screening and reduce the high false positive results. Key points: This study reports the results of lung cancer screening with LDCT in Gejiu, Yunnan, a high-risk area of lung cancer, and it demonstrates that lung cancer screening with LDCT is effective in detecting early-stage lung cancer. Our program provides an opportunity to explore the performance of LDCT lung cancer screening in the Chinese context.

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Demonstration program of population‐based lung cancer screening in China: Rationale and study design

Cited by 39 publications

References 30 publications

Early detection of lung cancer: Low‐dose computed tomography screening in China

Early detection of lung cancer: Low‐dose computed tomography screening in China

Cancer Prevention Research in China

Performance of lung cancer screening with low‐dose CT in Gejiu, Yunnan: A population‐based, screening cohort study

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