Demonstration of the neural crest origin of type I (APUD) cells in the avian carotid body, using a cytochemical marker system

Pearse, A. G. E.; Polak, Julia M.; Rost, Friedrich; Fontaine, J.; Lièvre, Christiane Ayer-Le; Douarin, Nicole Le

doi:10.1007/bf00303435

Cited by 171 publications

(68 citation statements)

References 37 publications

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“…Indeed, glomus and sustentacular cells, like sympathetic neurons and chromaffin cells of the adrenal medulla, originate from the neural crest and phenotypically resemble sympathoadrenal chromaffin cells [17,18]. Our data confirm prior findings demonstrating that NGF and its high-affinity receptor TrkA are preferentially expressed by the CB glomus cells [10].…”

Section: Discussionsupporting

confidence: 86%

Immunohistochemical Localization of Some Neurotrophic Factors and Their Receptors in the Rat Carotid Body

Atanasova¹,

Lazarov²

2013

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The carotid body (CB) is a small neural crest-derived organ that registers oxygen and glucose levels in blood and regulates ventilation. The most abundant cell type in the CB glomeruli is glomus or type I cells, which is enveloped by processes of sustentacular or type II cells. Growth and neurotrophic factors have been established as signaling molecules played an important role in the development of the CB. To gain insight whether these signaling molecules are present in the adult rat CB, we examined the expression and cellular localization of some neurotrophic factors and their corresponding receptors in this organ by immunohistochemistry. The results showed the presence of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF) as well as p75 NTR , tyrosine kinase A receptor (TrkA), tyrosine kinase B receptor (TrkB) and GDNF family receptor alpha1 (GFRα1) in the adult CB. At the light-microscopical level, the immunoreactivity for NGF and both its low-affinity (p75) and high-affinity (TrkA) receptors was detected in the majority of glomus cells and also in a subset of sustentacular cells. BDNF and its receptors, p75 and TrkB, were observed in the glomus cells, too. Remarkably, the immunohistochemical analysis revealed that the neuron-like glomus cells, but not the glial-like sustentacular cells, expressed GDNF and GFRα1. Taken together with prior results, it can be inferred that neurotrophins may be involved in the CB cell differentiation and survival in adulthood, and may exert a potent glomic protective action as well. It is also presumable that GDNF production by glomus cells plays a pivotal role in permitting long-term viability of CB grafts, which permits their potential applicability in cell therapy as a promising tool in neurodegenerative disorders.

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Section: Discussionsupporting

confidence: 86%

Immunohistochemical Localization of Some Neurotrophic Factors and Their Receptors in the Rat Carotid Body

Atanasova¹,

Lazarov²

2013

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“…Analysis of neural crest migration and differentiation has made rapid progress since LE DoUARIN (1969DoUARIN ( , 1971DoUARIN ( , 1973 found that the quail nucleus is distinguishable from that of the chick, and used the difference as a biological cell marker in the study of neural crest cell migration and differentiation .…”

Section: Discussionmentioning

confidence: 99%

Mesenchymal derivatives from the neural crest.

Nakamura

1982

Arch. Histol. Jap., Arch. Histol. Jpn

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“…4) (LE DOUARIN et al, 1972;PEARSE et al, 1973). The same observation was made for paraganglionic masses in the walls of arteries (LE LIEVRE and LE DoUARIN, 1973). Along with the nuclear marker which allowed grafted quail cells to be distinguished from the host chick cells, a cytochemical marker was found: Carotid body type I cells of both species elaborate different fluorogenic monoamines, mainly dopamine and some adrenaline and noradrenaline in quail cells, 5-IIT in chick cells (PEARSE , 1973).…”

Section: Carotid Body and Arterial Paragangliamentioning

confidence: 82%

“…As early as 7 to 8 days of incubation, cell groups whose origin has long been discussed appear inside the arterial walls or tightly tied to it (FoNTAINE, 1973). These cell groups form the carotid body, which plays a role as a chemoreceptor, and these paraganglionic masses more or less evenly dispersed in the walls of the arteries.…”

Section: Carotid Body and Arterial Paragangliamentioning

confidence: 99%

“…Under these conditions the whole carotid bodies (except for endothelial cells) were derived from the grafted neural crest; when treated consecutively for FIF and by Feulgen nuclear staining, the cells of the carotid bodies of such chimeras exhibited a bright greenish fluorescence, characteristic of quail type I cells and the heterochromatin rich nucleoli of the quail nuclei ( Fig. 4) (LE DOUARIN et al, 1972;PEARSE et al, 1973). The same observation was made for paraganglionic masses in the walls of arteries (LE LIEVRE and LE DoUARIN, 1973).…”

Section: Carotid Body and Arterial Paragangliamentioning

confidence: 99%

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The neural crest: Its relations with APUD and paraneuron concepts.

Lièvre

Fontaine-Pérus

1982

Arch. Histol. Jap., Arch. Histol. Jpn

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Abstract. The neural crest cells give rise to a large variety of derivatives including neural, mesenchymal, APUD and/or paraneuron cell types.A better knowledge of these derivatives was partly achieved through studies using LE DOUARIN's quail/chick marker system.We review here evidences which were thus provided for a neural crest origin of calcitonin containing cells, carotid body, aortic paraganglia, adrenomedulla, and against a neurectodermal origin of enterogastric and respiratory tract endocrine cells.The role of neural crest cells in PEARSE's APUD system is discussed. The results implicate that an explanation for the common properties of these cell types and their pathological and biochemical significance should not be looked for in a common embryological origin but at another level.The place of neural crest and, more generally, neurectoderm derivatives in the paraneuron concept of FUJITA is examined. The relevance of the epithelial origin of these cell types to their "receptosecretory" function is stressed.Considering neural crest itself as a unique system is still questioned and discussed here. Its ubiquity and penetration of other systems is pointed out as a widespread phenomenon which is not restricted to APUD and paraneuron systems.The study of the cells which arise from the neural crest received great impetus with the discovery of a new labelling system (LE DOUARIN, 1969, 1973 which was particularly suitable for this type of work. LE DOUARIN and collaborators then undertook a systemic study of neural crest derivatives casting a new light on this long known and somewhat controversial system (cf. reviews by HORsTADIUs,1950, WESTON,1970and LE DOUARIN, 1980. Part of their work dealt with mesectodermal derivatives (LE LIEVRE, 1971 LE LIEVRE and LE DOUARIN, 1975) which have been reviewed in this journal by NAKAMURA (1982). These studies also clarified the role of the neural crest in the formation of the peripheral nervous system (sensory, sympathetic and parasympathetic) (LE DOUARIN and TEILLET, 1971, 1973) and allowed the discovery of the neural crest origin of several other cell types. Currently known neural crest derivatives are listed in Table 1.Some time earlier PEARSE (1966) formulated the APUD concept which gathered

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Demonstration of the neural crest origin of type I (APUD) cells in the avian carotid body, using a cytochemical marker system

Cited by 171 publications

References 37 publications

Immunohistochemical Localization of Some Neurotrophic Factors and Their Receptors in the Rat Carotid Body

Immunohistochemical Localization of Some Neurotrophic Factors and Their Receptors in the Rat Carotid Body

Mesenchymal derivatives from the neural crest.

The neural crest: Its relations with APUD and paraneuron concepts.

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