Demonstration of the efficacy of curcumin on carbapenem-resistant Pseudomonas aeruginosa with Galleria mellonella larvae model

ÖZTÜRK, Şükran

doi:10.1007/s00203-022-03135-x

Cited by 4 publications

(6 citation statements)

References 52 publications

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“…In terms of inhibitory effects against gram-positive bacteria, P. aeruginosa strain ATCC27853 showed notable activity, exhibiting strong inhibition against S. aureus ATCC29213 and B. cereus ATCC14579 after 48 h of incubation. However, it showed no inhibition against S. aureus ATCC29213 and B. cereus ATCC14579 after 24 h. Similar studies have reported the varying inhibitory effects of P. aeruginosa strains against different gram-positive bacteria, highlighting the strain-specific nature of these effects [33][34][35].…”

Section: Discussionsupporting

confidence: 62%

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Enzyme Production and Inhibitory Potential of Pseudomonas aeruginosa: Contrasting Clinical and Environmental Isolates

Aqel,

Sannan,

Foudah

et al. 2023

Antibiotics

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(1) Background: This study summarizes the findings of two studies investigating the inhibitory effects of Pseudomonas aeruginosa strains from clinical and environmental sources against gram-positive and gram-negative bacteria and fungi. The studies also analyzed the correlation between enzyme production and inhibitory effects to gain insights into the antimicrobial capabilities of P. aeruginosa strains; (2) Methods: Both studies employed similar methodologies, including the use of disk diffusion and well diffusion methods to assess the inhibitory effects of P. aeruginosa strains against target pathogens. Enzyme production was analyzed through various biochemical assays to determine the diversity and frequencies of enzyme secretion among the strains; (3) Results: A comparative analysis of enzyme production in P. aeruginosa strains from clinical sources revealed significant variations in enzyme production, with hemolysin and protease being the most commonly produced enzymes. Gelatinase production showed lower rates, whereas chondroitinase and hyaluronidase were absent or occurred less frequently. In contrast, a comparative analysis of enzyme production in environmental isolates showed different patterns, indicating adaptation to environmental conditions. Pyocyanin production was absent in all environmental isolates. The inhibitory effects against gram-positive and gram-negative bacteria varied among different P. aeruginosa strains, with strain-specific variations observed. Limited inhibitory effects were observed against fungi, primarily toward gram-positive bacteria; (4) Conclusions: The findings highlight the strain-specific nature of inhibitory effects and enzyme production in P. aeruginosa strains. The correlation between enzyme production and inhibitory effects against gram-positive bacteria suggest a potential role of specific enzymes, such as hemolysin and protease, in the antimicrobial activity. The complexity of the relationship between enzyme production and the inhibition of different pathogens requires further investigation. The results emphasize the potential of P. aeruginosa strains as sources for antimicrobial strategies, particularly against gram-positive bacteria. Future research should focus on understanding the mechanisms underlying these inhibitory effects and exploring their therapeutic applications.

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Section: Discussionsupporting

confidence: 62%

“…However, it exhibited no inhibition against C. albicans ATCC10231. Previous studies have also reported the inhibitory effects of P. aeruginosa against gram-positive bacteria [ 33 , 34 , 35 ], but the observed variation in inhibition against C. albicans is an interesting finding.…”

Section: Discussionmentioning

confidence: 92%

Enzyme Production and Inhibitory Potential of Pseudomonas aeruginosa: Contrasting Clinical and Environmental Isolates

Aqel,

Sannan,

Foudah

et al. 2023

Antibiotics

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“…Compared to oral administration, i.p. injection can significantly increase plasma curcumin concentration (Pan and Wang, 2012). This suggests that the pharmacokinetic parameters may be affected by different routes of administration.…”

Section: Componentmentioning

confidence: 99%

“…An in vitro study testing the antibacterial and synergistic effects of curcumin against MRSA strains showed that curcumin had strong antibacterial activity and synergistic effects either alone or combination with certain antibiotics, namely oxacillin, ampicillin, ciprofloxacin, and norfloxacin) ( Mun et al, 2013 ). Additionally, another study demonstrated the synergistic effect of curcumin with antibiotics (e.g., imipenem and colistin) on Carbapenem-resistant Enterobacteriaceae in vitro and activity against Galleria mellonella larvae in vivo ( Ozturk, 2022 ). Those studies reveal the potential role of curcumin on multi-drug resistance and the possibility to drastically reduce the use of existing antibiotics.…”

Section: Pharmacological Actions Of Curcumae Rhizomamentioning

confidence: 99%

Curcumae Rhizoma: A botanical drug against infectious diseases

Tong

2023

Front. Pharmacol.

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Curcumae Rhizoma is the dry rhizome coming from Curcuma longa L. which grow widely in tropical south and southwest Asia. It has been used to treat conditions such as dermatoses, infections, stress, and depression. Moreover, in China, Curcumae Rhizoma and its active constituents have been made into different pharmaceutical preparations. Growing evidence suggests that these preparations can exert antioxidant, anti-inflammatory, and anti-cancer effects, which may play crucial roles in the treatment of various diseases, including cancer, infectious-, autoimmune-, neurological-, and cardiovascular diseases, as well as diabetes. The anti-infective effect of Curcumae Rhizoma has become a popular field of research around the world, including for the treatment of COVID-19, influenza virus, hepatitis B virus, human immunodeficiency virus, and human papilloma virus, among others. In this paper, the basic characteristics of Curcumae Rhizoma and its active constituents are briefly introduced, and we also give an overview on their applications and mechanisms in infectious diseases.

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“…Recently, scientists began to test the effectiveness of aPDT on G. mellonella infected with C. albicans using different PSs, such as methylene blue [214], erythrosine, curcumin, or toluidine blue [121,209,213]. In the dissertation of Dr. Dadi, the PS phloxine B was tested for toxicity in Galleria larvae, and even a 0.5 mM concentration did not exhibit any effect on G. mellonella survival [215].…”

Section: Principles Of Apdt and The Use Of G Mellonella In Apdtmentioning

confidence: 99%

Galleria mellonella—A Model for the Study of aPDT—Prospects and Drawbacks

Bugyna,

Kendra,

Bujdáková

2023

Microorganisms

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Galleria mellonella is a promising in vivo model insect used for microbiological, medical, and pharmacological research. It provides a platform for testing the biocompatibility of various compounds and the kinetics of survival after an infection followed by subsequent treatment, and for the evaluation of various parameters during treatment, including the host–pathogen interaction. There are some similarities in the development of pathologies with mammals. However, a limitation is the lack of adaptive immune response. Antimicrobial photodynamic therapy (aPDT) is an alternative approach for combating microbial infections, including biofilm-associated ones. aPDT is effective against Gram-positive and Gram-negative bacteria, viruses, fungi, and parasites, regardless of whether they are resistant to conventional treatment. The main idea of this comprehensive review was to collect information on the use of G. mellonella in aPDT. It provides a collection of references published in the last 10 years from this area of research, complemented by some practical experiences of the authors of this review. Additionally, the review summarizes in brief information on the G. mellonella model, its advantages and methods used in the processing of material from these larvae, as well as basic knowledge of the principles of aPDT.

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Demonstration of the efficacy of curcumin on carbapenem-resistant Pseudomonas aeruginosa with Galleria mellonella larvae model

Cited by 4 publications

References 52 publications

Enzyme Production and Inhibitory Potential of Pseudomonas aeruginosa: Contrasting Clinical and Environmental Isolates

Enzyme Production and Inhibitory Potential of Pseudomonas aeruginosa: Contrasting Clinical and Environmental Isolates

Curcumae Rhizoma: A botanical drug against infectious diseases

Galleria mellonella—A Model for the Study of aPDT—Prospects and Drawbacks

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