Demonstration of short-term plasticity in the dorsolateral prefrontal cortex with theta burst stimulation: A TMS-EEG study

Chung, Sung Wook; Lewis, Benjamin P.; Rogasch, Nigel C.; Saeki, Takashi; Thomson, Richard Hilton Siddall; Hoy, Kate Elizabeth; Bailey, Neil W.; Fitzgerald, Paul B.

doi:10.1016/j.clinph.2017.04.005

Cited by 101 publications

(113 citation statements)

References 79 publications

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“…In addition, the N100 deflection is considered to have a high sensitivity to small changes in cortical excitability compared with other TEPs (Nikulin, Kicic, Kahkonen, & Ilmoniemi, 2003), making it an ideal candidate for tracking neuromodulatory paradigms. Studies have reported N100 to be associated with GABA B -mediated inhibitory mechanisms in both motor (Bonnard et al, 2009;Farzan et al, 2013;Premoli, Rivolta, et al, 2014b;Rogasch, Daskalakis, et al, 2013a) and prefrontal cortex (Chung et al, 2017;Rogasch et al, 2015). The amplitude of N100 increased following SAI both in motor and prefrontal cortex (Noda et al, 2016;Noda, Zomorrodi, Backhouse, et al, 2017c), but decreased following cerebellar iTBS (Casula, Pellicciari, Ponzo, et al, 2016b), which are in line with the change observed in N100 following Ind iTBS.…”

Section: Effect Of Individualised Itbs On Plastic Effects In the Prsupporting

confidence: 74%

“…The amplitude of N100 increased following SAI both in motor and prefrontal cortex (Noda et al, 2016;Noda, Zomorrodi, Backhouse, et al, 2017c), but decreased following cerebellar iTBS (Casula, Pellicciari, Ponzo, et al, 2016b), which are in line with the change observed in N100 following Ind iTBS. However, our previous studies showed increased N100 following prefrontal iTBS (50 Hz at 5 Hz) (Chung et al, 2017;Chung, Rogasch, Hoy, & Fitzgerald, 2018a;Chung, Rogasch, Hoy, Sullivan, et al, 2018b), and the discrepancy of the outcome…”

Section: Effect Of Individualised Itbs On Plastic Effects In the Prmentioning

confidence: 82%

“…These peaks are commonly observed following prefrontal stimulation (Chung et al, 2017;Hill et al, 2017;Rogasch et al, 2014). These peaks are commonly observed following prefrontal stimulation (Chung et al, 2017;Hill et al, 2017;Rogasch et al, 2014).…”

Section: Tms-evoked Potentialsmentioning

confidence: 88%

“…Therefore, the inconsistent results between the current and previous studies may be due to inter-individual variability. LTD-like effects have previously been observed using cTBS (Chung et al, 2017) and pairedassociative stimulation (Casula, Pellicciari, Picazio, et al, 2016a) in the DLPFC, however, a complementary investigation is warranted. The variation could be reduced by accounting for the inter-individual neurophysiological differences in parameter design as observed in this study (Ind iTBS) and also in the motor cortex (Cash, Murakami, Chen, Thickbroom, & Ziemann, 2016).…”

Section: Effect Of Individualised Itbs On Plastic Effects In the Prmentioning

confidence: 95%

“…For the 3-back task, two-way repeated measure analysis of variance (ANOVAs) was used to investigate working memory perfor- N100 (95-135 ms) and P200 (160-240 ms)] and the amplitude was calculated by averaging the signal between AE5 ms of the selected peak latency as previously described (Chung et al, 2017). For the 3-back task, two-way repeated measure analysis of variance (ANOVAs) was used to investigate working memory perfor- N100 (95-135 ms) and P200 (160-240 ms)] and the amplitude was calculated by averaging the signal between AE5 ms of the selected peak latency as previously described (Chung et al, 2017).…”

Section: Statistical Analysesmentioning

confidence: 99%

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The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

Chung

Sullivan

Rogasch

et al. 2018

Human Brain Mapping

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Recent studies have highlighted variability in response to theta burst stimulation (TBS) in humans. TBS paradigm was originally developed in rodents to mimic gamma bursts coupled with theta rhythms, and was shown to elicit long‐term potentiation. The protocol was subsequently adapted for humans using standardised frequencies of stimulation. However, each individual has different rhythmic firing pattern. The present study sought to explore whether individualised intermittent TBS (Ind iTBS) could outperform the effects of two other iTBS variants. Twenty healthy volunteers received iTBS over left prefrontal cortex using 30 Hz at 6 Hz, 50 Hz at 5 Hz, or individualised frequency in separate sessions. Ind iTBS was determined using theta‐gamma coupling during the 3‐back task. Concurrent use of transcranial magnetic stimulation and electroencephalography (TMS‐EEG) was used to track changes in cortical plasticity. We also utilised mood ratings using a visual analogue scale and assessed working memory via the 3‐back task before and after stimulation. No group‐level effect was observed following either 30 or 50 Hz iTBS in TMS‐EEG. Ind iTBS significantly increased the amplitude of the TMS‐evoked P60, and decreased N100 and P200 amplitudes. A significant positive correlation between neurophysiological change and change in mood rating was also observed. Improved accuracy in the 3‐back task was observed following both 50 Hz and Ind iTBS conditions. These findings highlight the critical importance of frequency in the parameter space of iTBS. Tailored stimulation parameters appear more efficacious than standard paradigms in neurophysiological and mood changes. This novel approach presents a promising option and benefits may extend to clinical applications.

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Section: Effect Of Individualised Itbs On Plastic Effects In the Prsupporting

confidence: 74%

Section: Effect Of Individualised Itbs On Plastic Effects In the Prmentioning

confidence: 82%

Section: Tms-evoked Potentialsmentioning

confidence: 88%

Section: Effect Of Individualised Itbs On Plastic Effects In the Prmentioning

confidence: 95%

Section: Statistical Analysesmentioning

confidence: 99%

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The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

Chung

Sullivan

Rogasch

et al. 2018

Human Brain Mapping

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Neurophysiological markers of response to theta burst stimulation in youth depression

Dhami

Atluri

Lee

et al. 2020

Depression and Anxiety

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Background Theta burst stimulation (TBS) has recently been proposed as a novel treatment for youth depression. However, the impact of TBS on the youth brain and neurophysiological predictors of response to TBS in this population have not been investigated. Methods Cortical reactivity was assessed at baseline and following 2 weeks of bilateral dorsolateral prefrontal cortex (DLPFC) TBS treatment in 16 youth with depression (aged 16–24 years old). In 16 age‐matched health youths, cortical reactivity was assessed twice, 2 weeks apart. Transcranial magnetic stimulation (TMS) combined with electroencephalography was used to assess TMS‐evoked potentials in bilateral DLPFC, motor cortices, and intraparietal lobules (IPL). Resting‐state functional magnetic resonance imaging (fMRI) data was also collected at baseline. Results Left DLPFC pretreatment cortical reactivity, specifically the negativity at 45 ms (i.e., N45), which is related to GABAA neurotransmission, was associated with changes in depressive symptoms. Furthermore, TBS treatment was found to alter the N45 in the right IPL, a site distal to the treatment sites. The magnitude of the right IPL N45 modulation was correlated with the baseline fMRI connectivity between the right IPL and right DLPFC. Conclusions TMS‐probed cortical inhibition at the site of TBS application may have potential as a predictor of treatment response in youth depression. Furthermore, pre‐treatment functional connectivity may predict the impact of TBS on the neurophysiology of regions distal to the stimulation site. Collectively, these results offer novel neurophysiological insights into the application of TBS for youth depression, which may facilitate its wider use in the youth population.

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Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS‐EEG and working memory performance

Chung

Rogasch

Hoy

et al. 2017

Human Brain Mapping

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100

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Intermittent theta burst stimulation (iTBS) is a noninvasive brain stimulation technique capable of increasing cortical excitability beyond the stimulation period. Due to the rapid induction of modulatory effects, prefrontal application of iTBS is gaining popularity as a therapeutic tool for psychiatric disorders such as depression. In an attempt to increase efficacy, higher than conventional intensities are currently being applied. The assumption that this increases neuromodulatory may be mechanistically false for iTBS. This study examined the influence of intensity on the neurophysiological and behavioural effects of iTBS in the prefrontal cortex. Sixteen healthy participants received iTBS over prefrontal cortex at either 50, 75 or 100% resting motor threshold in separate sessions. Single-pulse TMS and concurrent electroencephalography (EEG) was used to assess changes in cortical reactivity measured as TMS-evoked potentials and oscillations. The n-back task was used to assess changes in working memory performance. The data can be summarised as an inverse U-shape relationship between intensity and iTBS plastic effects, where 75% iTBS yielded the largest neurophysiological changes. Improvement in reaction time in the 3-back task was supported by the change in alpha power, however, comparison between conditions revealed no significant differences. The assumption that higher intensity results in greater neuromodulatory effects may be false, at least in healthy individuals, and should be carefully considered for clinical populations. Neurophysiological changes associated with working memory following iTBS suggest functional relevance. However, the effects of different intensities on behavioural performance remain elusive in the present healthy sample.

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Demonstration of short-term plasticity in the dorsolateral prefrontal cortex with theta burst stimulation: A TMS-EEG study

Abstract: TBS is able to modulate cortical reactivity and cortical inhibition in the prefrontal cortex.

Cited by 101 publications

References 79 publications

The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

The effects of individualised intermittent theta burst stimulation in the prefrontal cortex: A TMS‐EEG study

Neurophysiological markers of response to theta burst stimulation in youth depression

Impact of different intensities of intermittent theta burst stimulation on the cortical properties during TMS‐EEG and working memory performance

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