Demonstration of resistance against methyleholanthrene-inducedsarcomas in primary autochthonous hosts

Klein, George; Sjögren, Hans‐Olov; Klein, E.; Hellström, Karin

doi:10.1097/00006534-196201000-00064

Cited by 190 publications

(247 citation statements)

References 0 publications

Supporting

Mentioning

235

Contrasting

Unclassified

Order By: Relevance

“…In fact, early studies of tumor immunology in animal models indicated that the Ags involved in the rejection of tumors, either transplanted (12) or primarily induced by chemicals or UV rays (13,14), were the unique Ags. Such Ags characterize each single neoplasm and were shown to be diverse between two tumors induced in the same animal or even in different tissue fragments of the same tumor nodule (15,16).…”

Section: Unique Ags and Their Main Featuresmentioning

confidence: 99%

Unique Human Tumor Antigens: Immunobiology and Use in Clinical Trials

Parmiani

Filippo

Novellino

et al. 2007

The Journal of Immunology

146

View full text Add to dashboard Cite

The individual, unique tumor Ags, which characterize each single tumor, were described 50 years ago in rodents but their molecular characterization was limited to few of them and obtained during the last 20 years. Here we summarize the evidence for the existence and the biological role of such Ags in human tumors, although such evidence was provided only during the last 10 years and by a limited number of studies, a fact leading to a misrepresentation of unique Ags in human tumor immunology. This was also due to the increasing knowledge on the shared, self-human tumor Ags, which have been extensively used as cancer vaccines. In this review, we highlight the biological and clinical importance of unique Ags and suggest how they could be used in clinical studies aimed at assessing their immunogenic and clinical potential both in active and adoptive immunotherapy of human tumors.

show abstract

Section: Unique Ags and Their Main Featuresmentioning

confidence: 99%

Unique Human Tumor Antigens: Immunobiology and Use in Clinical Trials

Parmiani

Filippo

Novellino

et al. 2007

The Journal of Immunology

146

View full text Add to dashboard Cite

show abstract

“…the antigenicity of these neoplasms is of a relatively weak order compared with murine sarcomata induced by classic chemical carcinogens (Klein et al, 1960). It is noteworthy that in this respect FBJ-MSV induced neoplasms are comparable with spontaneous murine neoplasms (Prehn and Main, 1957;Hammond, Fisher and Rolley, 1967) and with virus induced murine leukaemias of the Gross (G) or "wild " type subgroup Stettenmark and Klein, 1962) as opposed to leukaemias and sarcomata of the FMRGr subgroups which are much more strongly antigenic (Klein and Klein, 1964;Fefer et al, 1967a).…”

Section: Discussionmentioning

confidence: 99%

Tumour-Associated Transplantation Antigens of Neoplasms Induced by a Naturally Occurring Murine Sarcoma Virus (FBJ-MSV)

Jones¹,

Moore²

1973

Br J Cancer

View full text Add to dashboard Cite

Summary.-FBJ osteosarcoma virus (FBJ-MSV) isolated originally from a spontaneously arising osteosarcoma in a CFI mouse is the only known naturally occurring murine sarcoma virus (MSV). It is unique among strains of MSV in producing primarily sarcomata in mice. The capacity of tumour cells transformed in vivo by this agent to elicit specific transplantation immunity in syngeneic hosts was investigated. A low level of resistance (104-105 cells) was consistently induced by implantation of x-irradiated (15,000 rad) tumours or surgical excision of developing subcutaneous grafts. By contrast intraperitoneal inoculation of virus containing cell free extracts of FBJ-MSV sarcomata was a far less effective immunization procedure. Confirmatory evidence for the antigenicity of these neoplasms was obtained in tests in which preincubation of tumour cells with lymphoid cells from specifically immune donors inhibited in vivo outgrowth of the FBJ-MSV cells in untreated syngeneic recipients. The induction of host resistance to FBJ-MSV cells by immunization with identical and independently-induced FBJ-MSV tumours established that FBJ-MSV cells possess common cell surface antigenic specificities in a manner analogous to those of experimental neoplasms induced by other oncogenic DNA and RNA viruses. Since FBJ-MSV cells release infectious virus it was not possible in this system to establish whether the tumour-rejection antigen was cellular or virion in nature. The antigenic weakness of FBJ-MSV cells in syngeneic hosts is comparable with that of virus-induced murine leukaemias of the Gross (G) or " wild " type subgroup to which category FBJ-MSV also belongs. These features suggest that FBJ-MSV exemplifies naturally occurring sarcomagenic viruses more closely than those of the Friend-Moloney-Rauscher-Graffi (FMRGr) subgroup which in general induce highly antigenic neoplasms.

show abstract

“…These include histocompatibility antigens and tumour-associated antigens (TAA). Since they were identified (Prehn & Main, 1957;Klein et al, 1960;Old & Boyse, 1964), TAA have been regarded as a natural target for cancer immunotherapy. Yet immunotherapy through humoral or cellmediated manipulations has been so far ineffective (Rosenberg et al, 1977; Hawrylko, 1978; Motta, 1971).…”

mentioning

confidence: 99%

Characterization of a monoclonal antibody to L1210 leukaemia

Testorelli¹,

Morelli²,

Goldin³

et al. 1982

Br J Cancer

View full text Add to dashboard Cite

Summary.-A mouse monoclonal cell line (L1) was produced by fusing the mouse myeloma P3X63/Ag8 with CD2F1 spleen cells immunized with a highly immunogenic subline of L1210 leukaemia (Li210/DTIC). A very few positive clones (1%) were isolated and one of these was chosen for detailed study. The monoclonal antibody Li is an IgM immunoglobulin strongly reacting in a complement-dependent cytotoxicity assay against L1210/Cr leukaemia and its more or less inmmunogenic sublines. The specificity of the LI antibody against L1210 leukaemia was studied by extensive screening with normal adult and foetal tissues, lymphoid tissues from several independent strains and a panel of the most common experimental tumours, to all of which it was unreactive. Attempts at immunotherapy were carried out in DBA/2 mice challenged with L1210 leukaemia and treated with Li (ascites) and complement. Although the in vitro cytotoxic titre of ascites fluid from mice bearing hybridoma was very high (10-7), no therapeutic effect was obtained in vivo.

show abstract

Demonstration of resistance against methyleholanthrene-inducedsarcomas in primary autochthonous hosts

Cited by 190 publications

References 0 publications

Unique Human Tumor Antigens: Immunobiology and Use in Clinical Trials

Unique Human Tumor Antigens: Immunobiology and Use in Clinical Trials

Tumour-Associated Transplantation Antigens of Neoplasms Induced by a Naturally Occurring Murine Sarcoma Virus (FBJ-MSV)

Characterization of a monoclonal antibody to L1210 leukaemia

Contact Info

Product

Resources

About