Demonstration of Proton-Transfer Reaction Time-of-Flight Mass Spectrometry for Real-Time Analysis of Trace Volatile Organic Compounds

Blake, Robert S.; Whyte, Christopher; Hughes, Ceri O.; Ellis, Andrew M.; Monks, Paul S.

doi:10.1021/ac0498260

Cited by 187 publications

(132 citation statements)

References 11 publications

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“…PTR-MS instruments consist of four parts: an ion source where H 3 O + ions are produced, a drift tube section, a transition chamber and an ion detection section containing a quadrupole mass spectrometer or a TOF mass spectrometer (Blake et al, 2004) and a secondary electron multiplier. In the drift tube, the trace gases from the sample gas are ionized by proton transfer reactions with H 3 O + primary ions.…”

Section: Analysis and Detectionmentioning

confidence: 99%

Human exhaled air analytics: biomarkers of diseases

Buszewski

Kęsy

Ligor

et al. 2007

Biomedical Chromatography

657

531

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Over the last few years, breath analysis for the routine monitoring of metabolic disorders has attracted a considerable amount of scientific interest, especially since breath sampling is a non-invasive technique, totally painless and agreeable to patients. The investigation of human breath samples with various analytical methods has shown a correlation between the concentration patterns of volatile organic compounds (VOCs) and the occurrence of certain diseases. It has been demonstrated that modern analytical instruments allow the determination of many compounds found in human breath both in normal and anomalous concentrations. The composition of exhaled breath in patients with, for example, lung cancer, inflammatory lung disease, hepatic or renal dysfunction and diabetes contains valuable information. Furthermore, the detection and quantification of oxidative stress, and its monitoring during surgery based on composition of exhaled breath, have made considerable progress. This paper gives an overview of the analytical techniques used for sample collection, preconcentration and analysis of human breath composition. The diagnostic potential of different disease-marking substances in human breath for a selection of diseases and the clinical applications of breath analysis are discussed.

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Section: Analysis and Detectionmentioning

confidence: 99%

Human exhaled air analytics: biomarkers of diseases

Buszewski

Kęsy

Ligor

et al. 2007

Biomedical Chromatography

657

531

View full text Add to dashboard Cite

show abstract

“…A number of groups have used orthogonal acceleration time-of-flight mass spectrometers (oa-TOF-MS) in combination with a glow-discharge drift tube ion source (Blake et al, 2004;Ennis et al, 2005;Tanimoto et al, 2007;Jordan et al, 2009;Graus et al, 2010). None of those instruments has yet been deployed on an atmospheric chemistry research aircraft which is a particularly challenging measurement platform (short power-up time, shocks and vibrations during takeoff and landing, variable pressure and temperature in the cabin, contamination with polluted air at the airport, etc.).…”

Section: Introductionmentioning

confidence: 99%

A compact PTR-ToF-MS instrument for airborne measurements of volatile organic compounds at high spatiotemporal resolution

et al. 2014

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Abstract. Herein, we report on the development of a compact proton-transfer-reaction time-of-flight mass spectrometer (PTR-ToF-MS) for airborne measurements of volatile organic compounds (VOCs). The new instrument resolves isobaric ions with a mass resolving power (m/ m) of ∼ 1000, provides accurate m/z measurements ( m < 3 mDa), records full mass spectra at 1 Hz and thus overcomes some of the major analytical deficiencies of quadrupole-MS-based airborne instruments. 1 Hz detection limits for biogenic VOCs (isoprene, α total monoterpenes), aromatic VOCs (benzene, toluene, xylenes) and ketones (acetone, methyl ethyl ketone) range from 0.05 to 0.12 ppbV, making the instrument wellsuited for fast measurements of abundant VOCs in the continental boundary layer. The instrument detects and quantifies VOCs in locally confined plumes (< 1 km), which improves our capability of characterizing emission sources and atmospheric processing within plumes. A deployment during the NASA 2013 DISCOVER-AQ mission generated high vertical-and horizontal-resolution in situ data of VOCs and ammonia for the validation of satellite retrievals and chemistry transport models.

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“…Hansel et al, 1995) or more recently an ion-trap . Our group demonstrated the first PTR-MS system using TOF-MS (Blake et al, 2004). More recently Ennis et al (2005) and Inomota et al (2006) have developed similar systems.…”

Section: Introductionmentioning

confidence: 92%

Technical Note: Performance of Chemical Ionization Reaction Time-of-Flight Mass Spectrometry (CIR-TOF-MS) for the measurement of atmospherically significant oxygenated volatile organic compounds

et al. 2007

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Abstract. The performance of a new chemical ionization reaction time-of-flight mass spectrometer (CIR-TOF-MS) utilising the environment chamber SAPHIR (Simulation of Atmospheric Photochemistry In a large Reaction ChamberForschungzentrum Jülich, Germany) is described. The work took place as part of the ACCENT (Atmospheric Composition and Change the European NeTwork for excellence) supported oxygenated volatile organic compound (OVOC) measurement intercomparison during January 2005. The experiment entailed the measurement of 14 different atmospherically significant OVOCs at various mixing ratios in the approximate range 10.0-0.6 ppbV. The CIR-TOF-MS operated throughout the exercise with the hydronium ion (H 3 O + ) as the primary chemical ionization (CI) reagent in order to facilitate proton transfer to the analyte OVOCs. The results presented show that the CIR time-of-flight mass spectrometer is capable of detecting a wide range of atmospheric OVOCs at mixing ratios of around 10 ppbV in "real-time" (i.e. detection on the one-minute time scale), with sub-ppbV measurement also achieved following an increase in averaging time to tens of minutes. It is shown that in general OVOC measurement is made with high accuracy and precision, with integration time, mixing ratio and compound dependent values as good as 4-13% and 3-15% respectively. It is demonstrated that CIR-TOF-MS has rapid multi-channel response at the required sensitivity, accuracy and precision for atmospheric OVOC measurement.

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Demonstration of Proton-Transfer Reaction Time-of-Flight Mass Spectrometry for Real-Time Analysis of Trace Volatile Organic Compounds

Cited by 187 publications

References 11 publications

Human exhaled air analytics: biomarkers of diseases

Human exhaled air analytics: biomarkers of diseases

A compact PTR-ToF-MS instrument for airborne measurements of volatile organic compounds at high spatiotemporal resolution

Technical Note: Performance of Chemical Ionization Reaction Time-of-Flight Mass Spectrometry (CIR-TOF-MS) for the measurement of atmospherically significant oxygenated volatile organic compounds

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