Demonstration of peptidergic afferents to the bed nucleus of the stria terminalis using local injections of colchicine. A combined immunohistochemical and retrograde tracing study

Arluison, Michel; Brochier, Guy; Vankova, Myriana; Leviel, Vincent; Villalobos, Julio; Tramu, G.

doi:10.1016/0361-9230(94)90026-4

Cited by 44 publications

(30 citation statements)

References 91 publications

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“…The members of the LIMhd family xLhx1 and xLhx7 have been shown to be good territorial markers in the brain of anurans , and they have been used recently in the study of the developing amniote subpallium, in which they were very useful in the identification of the BST boundaries (García-López et al, 2008;Abellán andMedina, 2008, 2009). Additionally, the combinations with the markers ENK, SP, TH, and CR, used in previous studies of the BST in tetrapods (Moga et al, 1989;Arluison et al, 1994;Jurkevich et al, 1999;Hasue and ShammahLagnado, 2002;Real et al, 2008;Moreno et al, 2010), allowed us to distinguish distinct telencephalic regions in anurans, because these markers highlight boundaries in the basal telencephalon and are distinctly distributed in the anuran BST Marín et al, 1998a,b;Milán and Puelles, 2000;Smeets and González, 2000;González, 2003, 2006;Morona and González, 2008).…”

Section: Discussionmentioning

confidence: 99%

“…Important dopaminergic fibers reach the lateral BST and the CeA, originating mainly in the A10 (VTA) cell group but also in the periventricular gray-A11 group and the parabrachial pigmented and caudal linear nuclei (Hasue and Shammah-Lagnado, 2002). In addition, it has also been demonstrated that the substantia nigra and the nucleus of the solitary tract provide dopaminergic innervation to the BST (Arluison et al, 1994). Knowledge on the anatomical organization of the dopaminergic projections to the extended amygdala, including the BST, is a necessary step for a better understanding of the functional phenomena related to these areas.…”

Section: Mammalsmentioning

confidence: 99%

“…Tract-tracing studies have demonstrated the presence of peptidergic afferents to the BST, i.e., ENK, neurotensin, and SP (Arluison et al, 1994). The origin of the peptidergic innervation was found, at least in part, in the paraventricular nucleus of the thalamus (Arluison et al, 1994).…”

Section: Mammalsmentioning

confidence: 99%

“…The origin of the peptidergic innervation was found, at least in part, in the paraventricular nucleus of the thalamus (Arluison et al, 1994). In addition, important projections from the ventromedial nucleus of the hypothalamus to the ipsilateral BST were demonstrated and most likely utilize ENK and SP as neurotransmitters (Arluison et al, 1994).…”

Section: Mammalsmentioning

confidence: 99%

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Characterization of the bed nucleus of the stria terminalis in the forebrain of anuran amphibians

Moreno

Morona

López

et al. 2011

J of Comparative Neurology

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Major common features have been reported for the organization of the basal telencephalon in amniotes, and most characteristics were thought to be acquired in the transition from anamniotes to amniotes. However, gene expression, neurochemical, and hodological data obtained for the basal ganglia and septal and amygdaloid complexes in amphibians (anamniotic tetrapods) have strengthened the idea of a conserved organization in tetrapods. A poorly characterized region in the forebrain of amniotes has been the bed nucleus of the stria terminalis (BST), but numerous recent investigations have characterized it as a member of the extended amygdala. Our study analyzes the main features of the BST in anuran amphibians to establish putative homologies with amniotes. Gene expression patterns during development identified the anuran BST as a subpallial, nonstriatal territory. The BST shows Nkx2.1 and Lhx7 expression and contains an Islet1-positive cell subpopulation derived from the lateral ganglionic eminence. Immunohistochemistry for diverse peptides and neurotransmitters revealed that the distinct chemoarchitecture of the BST is strongly conserved among tetrapods. In vitro tracing techniques with dextran amines revealed important connections between the BST and the central and medial amygdala, septal territories, medial pallium, preoptic area, lateral hypothalamus, thalamus, and prethalamus. The BST receives dopaminergic projections from the ventral tegmental area and is connected with the laterodorsal tegmental nucleus and the rostral raphe in the brainstem. All these data suggest that the anuran BST shares many features with its counterpart in amniotes and belongs to a basal continuum, likely controlling similar reflexes, reponses, and behaviors in tetrapods.

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Section: Discussionmentioning

confidence: 99%

Section: Mammalsmentioning

confidence: 99%

Section: Mammalsmentioning

confidence: 99%

Section: Mammalsmentioning

confidence: 99%

See 2 more Smart Citations

Characterization of the bed nucleus of the stria terminalis in the forebrain of anuran amphibians

Moreno

Morona

López

et al. 2011

J of Comparative Neurology

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“…One notable feature of the BNST as well as the lateral CeA (which projects to the BNST), which distinguishes both from the medial CeA, is the abundance of so many different neuropeptide-positive cells and terminals (Roberts et al, 1982;Woodhams et al, 1983;Cassell et al, 1986;Ju et al, 1989;Shimada et al, 1989;Walter et al, 1991;Gray and Magnuson, 1992;Arluison et al, 1994). Because peptides often act for long periods of time, as we have found from local BNST infusions of either CRF (Liang et al, 1992) or CGRP (Sink et al, 2011), we believe that accelerated development of small molecule ligands for these receptors, and their evaluation in anxiety models such as the one used here, may be a prudent strategy for the development of new anxiolytic compounds with novel mechanisms of action.…”

Section: Discussionmentioning

confidence: 99%

Phasic and Sustained Fear are Pharmacologically Dissociable in Rats

Miles

Davis

Walker

2011

Neuropsychopharmacol

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Previous findings suggest differences in the neuroanatomical substrates of short-(seconds) vs longer-duration (minutes) fear responses. We now report that phasic and sustained fear can also be differentiated pharmacologically, based on their response to several treatments that either are or are not clinically effective anxiolytics. For these experiments, short-or long-duration clicker stimuli were paired with footshock. Acoustic startle amplitude was later measured in the absence of the clicker, or within seconds (phasic fear) or minutes (sustained fear) of its onset. Before testing, rats received a single injection of vehicle, the benzodiazepine chlordiazepoxide, the 5HT 1A agonist and dopamine D2 antagonist buspirone, the selective serotonin reuptake inhibitor fluoxetine, or a 3-week treatment with either vehicle or fluoxetine. Chlordiazepoxide blocked sustained, but not phasic startle increases. Acute buspirone, which is not anxiolytic in human beings, did not affect sustained startle increases, but did disrupt phasic increases. Chronic fluoxetine blocked sustained startle increases and unreliably reduced phasic increases; acute fluoxetine affected neither. The results indicate that phasic and sustained fear responses can be pharmacologically dissociated, further validating this distinction, and suggest that sustained startle increases may be especially useful as anxiety models and anxiolytic screens.

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Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain

Sharp

Nucifora

Blondel³

et al. 1999

J. Comp. Neurol.

186

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Inositol 1,4,5-trisphosphate receptors (IP 3 R) are mediators of second messenger-induced intracellular calcium release. Three isoforms are known to be expressed in brain, but their regional distributions and cellular localizations are little known. In order to better understand the roles of IP 3 receptor isoforms in brain function, a first step is to define their distributions. We have used affinity-purified antibodies directed against peptides unique to each isoform to determine their sites of expression in rat brain. Type 1 IP 3 R (IP 3 R1) is dramatically enriched in Purkinje neurons in cerebellum and neurons in other regions, consistent with previous studies. By contrast, IP 3 R2 is only detected in glia, whereas IP 3 R3 is predominantly neuronal, with little detected in glia. IP 3 R3 is enriched in neuropil, especially in neuronal terminals (which often contain large dense core vesicles) in limbic and basal forebrain regions including olfactory tubercle, central nucleus of the amygdala, and bed nucleus of the stria terminalis. In addition, IP 3 R1 and IP 3 R3 have clearly distinct time courses of expression in developing brains. These data suggest separate roles for inositol 1,4,5trisphosphate receptor isoforms in development, and for glial and neuronal function. The IP 3 R3 may be involved in regulation of neurotransmitter or neuropeptide release in terminals within specific nuclei of the basal forebrain and limbic system.

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Demonstration of peptidergic afferents to the bed nucleus of the stria terminalis using local injections of colchicine. A combined immunohistochemical and retrograde tracing study

Cited by 44 publications

References 91 publications

Characterization of the bed nucleus of the stria terminalis in the forebrain of anuran amphibians

Characterization of the bed nucleus of the stria terminalis in the forebrain of anuran amphibians

Phasic and Sustained Fear are Pharmacologically Dissociable in Rats

Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain

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