Demonstration of in Vitro Lymphocyte-Mediated Cytotoxicity against Measles Virus in Sspe

Kreth, W; Käckell, M. Y.; Meulen, Volker ter

doi:10.4049/jimmunol.114.3.1042

Cited by 34 publications

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Long‐term follow‐up of patients with subacute sclerosing panencephalitis treated with inosiplex

Dyken

Swift

DuRant

1982

Annals of Neurology

106

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During the past five years, 15 patients with subacute sclerosing panencephalitis (SSPE) were treated with inosiplex. Using a disability index specifically designed for the disease, this study monitored the course of SSPE in each patient before and during inosiplex therapy. Posttreatment follow-up ranged from 2 to 144 months. Inosiplex had an apparently beneficial effect on morbidity and mortality in 10 of the 15 patients tested. Eight improved immediately after treatment, 2 had a delayed improvement, and 1 patient stabilized. Four patients followed a typical course for SSPE and died a mean 9 months after onset. Treatment was not associated with adverse reactions. Due to its low risk-benefit ratio, inosiplex is recommended for continuous use in SSPE even after extended remissions.

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Long‐term follow‐up of patients with subacute sclerosing panencephalitis treated with inosiplex

Dyken

Swift

DuRant

1982

Annals of Neurology

106

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Impaired human leukocyte antigen–restricted measles virus–specific cytotoxic T‐cell response in subacute sclerosing panencephalitis

Dhib‐Jalbut

Jacobson

McFarlin

et al. 1989

Annals of Neurology

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The capacity of peripheral blood lymphocytes to proliferate in response to measles virus and to generate measles virusspecific cytotoxic T lymphocytes (CTL) was examined in 4 patients with subacute sclerosing panencephalitis (SSPE). The lymphoproliferative response to measles virus was obtainable in the 4 SSPE patients. In contrast, the CTL response to measles virus was reduced in 3 of the 4 SSPE patients. This defect appeared to be in the generation of the measles virus-specific CTLs, since measles virus-infected target cells from the patients could be lysed by human leukocyte antigen-matched peripheral blood lymphocytes from healthy individuals. The SSPE patients with reduced measles virus CTL response had a normal ability to generate mumps virus, influenza virus, or alloantigen-specific CTLs. The lysis of measles virus-infected targets that was observed with these SSPE patients could be reduced by depleting the effectors of natural killer cells or by performing cold target blocking with K562 cells, indicating that the lysis of the measles virus-infected targets was probably mediated by natural killer cells. These results demonstrate a reduction in the cell-mediated immune response to measles virus as measured by the generation of measles virus-specific CTLs in 3 of the 4 SSPE patients studied. This defect could relate to the persistence of measles virus in these patients.

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Virus Infection in Demyelinating Diseases

Meulen

Wege

1978

Advances in Experimental Medicine and Biology

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Demonstration of in Vitro Lymphocyte-Mediated Cytotoxicity against Measles Virus in Sspe

Cited by 34 publications

References 0 publications

Long‐term follow‐up of patients with subacute sclerosing panencephalitis treated with inosiplex

Long‐term follow‐up of patients with subacute sclerosing panencephalitis treated with inosiplex

Impaired human leukocyte antigen–restricted measles virus–specific cytotoxic T‐cell response in subacute sclerosing panencephalitis

Virus Infection in Demyelinating Diseases

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