Demonstration of Excessive Metabolic Activity of Thoracic and Abdominal Muscles on FDG-PET in Patients With Chronic Obstructive Pulmonary Disease

Abstract

This study demonstrates the ability of FDG-PET imaging to assess muscle function in respiratory disorders and may prove to be of some value in further characterizing this disorder.

Role of Modern Imaging Techniques for Diagnosis of Infection in the Era of18F-Fluorodeoxyglucose Positron Emission Tomography

“…Certain conditions have been shown to increase FDG uptake: (i) benign infection of the lungs or mediastinum (100,102,146,167,179), appendix (82), gall bladder (80,173), and many other organs (64,70,114,135,140); (ii) inflammation without infection, including sarcoidosis (55), pulmonary artery thrombosis (50), abdominal aortic aneurysm (37), and inflammatory arthritis (75); (iii) normal variants, such as brown fat (131), ovaries during ovulation (147), calyceal diverticula (76), the postpartum uterus (93), and activated respiratory muscles in patients with chronic obstructive pulmonary disease (11) or other conditions (172); (iv) atrogenic conditions, such as those related to immunization (165), barium aspiration (51,94), and intravenous line or pacemaker infection (110,159); (v) trauma (67,115), whether spontaneous or following surgery (14,174); and (vi) benign processes such as elastofibroma dorsi (124,163), progressive fibrosis, and benign mesenchymal tumors (30,83,105,161). Although infectious or inflammatory processes frequently pose a diagnostic challenge in the evaluation of patients with cancer (148), the possibility that malignant lesions may also mimic infectious or inflammatory disease (9,28) should not be overlooked.…”

Diffuse Skeletal Muscles Uptake of [18F] Fluorodeoxyglucose on Positron Emission Tomography in Primary Muscle Peripheral T-cell Lymphoma

“…However, other reasons for skeletal muscle fluorodeoxyglucose uptake may stem from a variety of factors such as physical exertion, talking, and chewing as normal physiological phenomena (15). As for pathological phenomena, elevated fluorodeoxyglucose muscle may be associated with anxiety-induced neck muscle spasm (15), accessory muscle use in respiratory distress (16), intercostal and diaphragmatic activity in chronic obstructive pulmonary disease (17), abdominal muscle contraction in intractable vomiting (18), sepsis-induced shivering (19), hypoglycemia (20), infection, and inflammation of the muscle tissue that increases glycolytic activity (21,22). In the present case, the patient did not satisfy these conditions.…”

Etiopathologies Associated with Intercostal Muscle Hypermetabolism and Prominent Right Ventricle Visualization on 2-Deoxy-2[F-18]fluoro-d-glucose-Positron Emission Tomography: Significance of an Incidental Finding and in the Setting of a Known Pulmonary Disease

“…At times, images may appear confusing and may be misinterpreted. To date there has been one study [1] examining FDG activity of thoracic muscles on FDG-PET in patients with compared 25 patients with COPD and 25 patients without COPD who have undergone a FDG-PET study. They concluded that patients with COPD demonstrated excessive metabolic activity of thoracic and abdominal muscles compared to those without known COPD.…”