Demonstration of a fiber-optical light-force trap

Constable, A.; Kim, Jinha; Mervis, Jeffrey; Zarinetchi, F.; Prentiss, Mara

doi:10.1364/ol.18.001867

Cited by 318 publications

(180 citation statements)

References 6 publications

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“…Constable et al (1993) tried to place two beams in an exactly counter-propagating way and they provided an equation to calculate the scattering force for these two beams. The gradient and scattering forces are shown in figure 1e.…”

Section: Instrumentmentioning

confidence: 99%

Optical tweezers for single cells

Zhang

Liu

2008

J. R. Soc. Interface.

665

441

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Optical tweezers (OT) have emerged as an essential tool for manipulating single biological cells and performing sophisticated biophysical/biomechanical characterizations. Distinct advantages of using tweezers for these characterizations include non-contact force for cell manipulation, force resolution as accurate as 100 aN and amiability to liquid medium environments. Their wide range of applications, such as transporting foreign materials into single cells, delivering cells to specific locations and sorting cells in microfluidic systems, are reviewed in this article. Recent developments of OT for nanomechanical characterization of various biological cells are discussed in terms of both their theoretical and experimental advancements. The future trends of employing OT in single cells, especially in stem cell delivery, tissue engineering and regenerative medicine, are prospected. More importantly, current limitations and future challenges of OT for these new paradigms are also highlighted in this review.

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Section: Instrumentmentioning

confidence: 99%

Optical tweezers for single cells

Zhang

Liu

2008

J. R. Soc. Interface.

665

441

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“…OS basic idea relies on a double beam laser trap [113] obtained with two counter-propagating beams [114,115]. Increasing the laser power, the radiation pressure exerted by the two beams over the trapped cell surface leads to an elongation of the cell along the beam axis, providing useful information on the cell health.…”

Section: Cell Trapping and Stretchingmentioning

confidence: 99%

“…Increasing the laser power, the radiation pressure exerted by the two beams over the trapped cell surface leads to an elongation of the cell along the beam axis, providing useful information on the cell health. Although the effectiveness of the OS has been widely demonstrated, the typical set-ups, based on assembling optical fibers with glass capillaries or polymeric microchannels, present some criticalities mainly due to the fine and stable alignment required between discrete optical and microfluidic components [112,114].…”

Section: Cell Trapping and Stretchingmentioning

confidence: 99%

Femtosecond laser microstructuring: an enabling tool for optofluidic lab‐on‐chips

Osellame

Hoekstra

Cerullo

et al. 2011

Laser & Photonics Reviews

287

226

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This paper provides an overview of the rather new field concerning the applications of femtosecond laser microstructuring of glass to optofluidics. Femtosecond lasers have recently emerged as a powerful microfabrication tool due to their unique characteristics. On the one hand, they enable to induce a permanent refractive index increase, in a micrometer-sized volume of the material, allowing single-step, three-dimensional fabrication of optical waveguides. On the other hand, femtosecond-laser irradiation of fused silica followed by chemical etching enables the manufacturing of directly buried microfluidic channels. This opens the intriguing possibility of using a single laser system for the fabrication and three-dimensional integration of optofluidic devices. This paper will review the state of the art of femtosecond laser fabrication of optical waveguides and microfluidic channels, as well as their integration for high sensitivity detection of biomolecules and for cell manipulation.

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“…To validate the chip functionality and versatility, we present results obtained through the utilization of the chips for both optical stretching of red blood cells (RBCs) and for in-fiber Raman spectroscopy of liquids. Both techniques require a high level of alignment precision and coupling [12], for this reason they are considered ideal examples for the application and validation of the technology. Compared to earlier demonstrations of optofluidic devices with embedded commercial optical fibers [10,11] the reported chip fabrication process is production ready and allows the height of the optical beam path relative to the microfluidic channel to be tuned easily in the design phase.…”

Section: Introductionmentioning

confidence: 99%

“…To validate the chip functionality and versatility, we present results obtained through the utilization of the chips for both optical stretching of red blood cells (RBCs) and for in-fiber Raman spectroscopy of liquids. Both techniques require a high level of alignment precision and coupling [12], for this reason they are considered ideal examples for the application and validation of the technology. Figure 2 shows a scanning electron microscopy image (Figure 2a) of the Ni stamp (here referred to as shim) together with optical ( Figure 2b) and mechanical (Figure 2c) profilometry data of the polymer chip.…”

Section: Introductionmentioning

confidence: 99%

Fiber-Based, Injection-Molded Optofluidic Systems: Improvements in Assembly and Applications

et al. 2015

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Abstract:We present a method to fabricate polymer optofluidic systems by means of injection molding that allow the insertion of standard optical fibers. The chip fabrication and assembly methods produce large numbers of robust optofluidic systems that can be easily assembled and disposed of, yet allow precise optical alignment and improve delivery of optical power. Using a multi-level chip fabrication process, complex channel designs with extremely vertical sidewalls, and dimensions that range from few tens of nanometers to hundreds of microns can be obtained. The technology has been used to align optical fibers in a quick and precise manner, with a lateral alignment accuracy of 2.7˘1.8 µm. We report the production, assembly methods, and the characterization of the resulting injection-molded chips for Lab-on-Chip (LoC) applications. We demonstrate the versatility of this technology by carrying out two types of experiments that benefit from the improved optical system: optical stretching of red blood cells (RBCs) and Raman spectroscopy of a solution loaded into a hollow core fiber. The advantages offered by the presented technology are intended to encourage the use of LoC technology for commercialization and educational purposes.

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Demonstration of a fiber-optical light-force trap

Cited by 318 publications

References 6 publications

Optical tweezers for single cells

Optical tweezers for single cells

Femtosecond laser microstructuring: an enabling tool for optofluidic lab‐on‐chips

Fiber-Based, Injection-Molded Optofluidic Systems: Improvements in Assembly and Applications

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