Demonstration and identification of monoclonal proteins in the urine of patients with Sjogren's syndrome.

Moutsopoulos, H M; Costello, Rene; Drosos, Alexandros A.; Mavridis, Anestis; Papadopoulos, N M

doi:10.1136/ard.44.2.109

Cited by 68 publications

(25 citation statements)

References 12 publications

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“…In patients with mild disease, manifest by sicca symptoms alone, such hypergammaglobulinemia is usually polyclonal, but oligoclonal or monoclonal gammopathies appear in patients with more severe lymphoproliferation and extraglandular manifestations (Tzioufas et al, 1987). A large number of patients had monoclonal immunoglobulins in their serum or urine (Moutsopoulos et al, 1983(Moutsopoulos et al, , 1985 when testing was done with high-sensitivity assays. The incidence was more common in urine than in serum and increased with disease severity.…”

Section: Polyclonal and Monoclonal Gammopathies In Sjogren F S Syndromementioning

confidence: 99%

Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjögren's Syndrome

Fox

Speight

1996

Critical Reviews in Oral Biology & Medicine

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Sjogren's syndrome is a systemic autoimmune disorder characterized by symptoms of oral and ocular dryness and a chronic, progressive loss of salivary and lacrimal function. The exocrine involvement is the result of a focal, peri-ductal mononuclear cell infiltrate and the subsequent loss of secretory epithelial cells. The mechanisms of this autoimmune exocrinopathy are not understood fully. Many recent investigations have described alterations in a number of immune mediators within the salivary glands. These studies provide new insights into the immune regulation of normal salivary gland functions and the mechanisms of gland damage in Sjogren's syndrome.

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Section: Polyclonal and Monoclonal Gammopathies In Sjogren F S Syndromementioning

confidence: 99%

Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjögren's Syndrome

Fox

Speight

1996

Critical Reviews in Oral Biology & Medicine

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“…Analogous observa tions have been made by other investigators using sim ilar techniques in Burkitt's lymphoma [8]. Sjogren's syndrome [9][10][11], diffuse well-differentiated lympho cytic lymphoma [12] and lymphoplasmacytic lym phoma [13].…”

Section: Introductionmentioning

confidence: 55%

Monoclonal and Oligoclonal Immunoglobulins in the Serum of Patients with B-Chronic Lymphocytic Leukemia

et al. 1988

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The incidence of monoclonal and oligoclonal immunoglobulins (paraproteins) was determined in serum samples of 45 chronic lymphocytic leukemia (B-CLL) patients using the high-resolution agarose gel electrophoresis technique combined with immunofixation. Paraproteins were identified in 25 of the 45 patients tested. Twelve paraproteins were monoclonal and 13 oligoclonal. IgG k and/or λ immunoglobulin isotypes were found in 17/25 of these patients. No correlation of the lymphocyte cell morphology and the presence of paraproteins was demonstrated. The high frequency of serum oligoclonal immunoglobulins in B-CLL indicates that more than one lymphocyte clone may be present in this disease.

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“…Recent studies have demonstrated the presence of a monoclonal K or A light chain in the sera and urine of all patients with extraglandular disease (21,22). This finding suggests that the monoclonal process may start very early in the process of this disease, along with the polyclonal B lymphocyte hyperreactivity .…”

Section: Discussionmentioning

confidence: 99%

Cryoglobulinemia in autoimmune rheumatic diseases: Evidence of circulating monoclonal cryoglobulins in patients with primary Sjögren's syndrome

Tzioufas

Manoussakis

Costello

et al. 1986

Arthritis & Rheumatism

105

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The incidence and nature of cryoglobulins, as well ais their correlation with the clinical and serologic picture of Sjogren's syndrome (SS), were studied in the sera of 30 consecutive primary SS patients. Sera from 29 patients with systemic lupus erythematosus, 58 patients with rheumatoid arthritis, and 125 healthy blood donors were also studied. It was shown that one-third of the patients with SS had cryoglobulinemia. These cryoglobulins were mixed monoclonal IgM immunoglobullins, whereas those observed in systemic lupus erythematosus and rheumatoid arthritis patients were mixed polyclonal. The nature of the cryoglobulins was demoinstrated using high-resolution electrophoresis combined with immunoiixation. The presence of cryoglobulins in the sera of SS patients correlated with extraglandular disease and with antibodies to Ro (SS-A) and IgM rheumatoid factor. SS patients with cryoglobulins had lower serum C4 levels than did patients without cryoglobulins. These findings suggest that SS expresses, in addition to polyclonal B cell hyperreactivity, a monoclonal process in the absence of lymphoid neoplaaia. Further, they show that the extraglandular

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Demonstration and identification of monoclonal proteins in the urine of patients with Sjogren's syndrome.

Cited by 68 publications

References 12 publications

Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjögren's Syndrome

Current Concepts of Autoimmune Exocrinopathy: Immunologic Mechanisms in the Salivary Pathology of Sjögren's Syndrome

Monoclonal and Oligoclonal Immunoglobulins in the Serum of Patients with B-Chronic Lymphocytic Leukemia

Cryoglobulinemia in autoimmune rheumatic diseases: Evidence of circulating monoclonal cryoglobulins in patients with primary Sjögren's syndrome

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