Demonstrating new-onset or worsened sudomotor function post-COVID-19 on comparative analysis of autonomic function pre-and post-SARS-CoV-2 infection

Varma-Doyle, Aditi; Villemarette-Pittman, Nicole R.; LeLorier, Paul; England, John D.

doi:10.1016/j.ensci.2023.100445

Cited by 7 publications

(3 citation statements)

References 13 publications

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“…One such study by Erdal et al [ 57 ] found that 21.8% of their 112 COVID-19 patients experienced diarrhea. Another study by Varma-Doyle et al [ 58 ] noted that five of six patients with dysautonomia experienced gastrointestinal symptoms such as bloating, nausea, vomiting, constipation, irregular bowel movements, and early satiety. Scala et al 's research showed that 26.3% of COVID-19 patients developed diarrhea, compared to only 7.9% of the control group[ 59 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19-induced gastrointestinal autonomic dysfunction: A systematic review

Elbeltagi¹,

Al‐Biltagi²,

Saeed³

et al. 2023

World J Clin Cases

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In recent years, because of the growing desire to improve the noninvasiveness and safety of tumor treatments, sonodynamic therapy has gradually become a popular research topic. However, due to the complexity of the therapeutic process, the relevant mechanisms have not yet been fully elucidated. One of the widely accepted possibilities involves the effect of reactive oxygen species. In this review, the mechanism of reactive oxygen species production by sonodynamic therapy (SDT) and ways to enhance the sonodynamic production of reactive oxygen species are reviewed. Then, the clinical application and limitations of SDT are discussed. In conclusion, current research on sonodynamic therapy should focus on the development of sonosensitizers that efficiently produce active oxygen, exhibit biological safety, and promote the clinical transformation of sonodynamic therapy.

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Section: Discussionmentioning

confidence: 99%

COVID-19-induced gastrointestinal autonomic dysfunction: A systematic review

Elbeltagi¹,

Al‐Biltagi²,

Saeed³

et al. 2023

World J Clin Cases

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“…An abnormal test is considered a diagnosis of cardiovascular autonomic dysfunction, and two or more abnormal tests for the diagnosis of cardiovascular autonomic neuropathy ( 63 ). The assessment of sudomotor function is another diagnostic strategy to consider in selected patients, as it has demonstrated its utility in evaluating dysautonomia in individuals with post–COVID-19 sequelae ( 64 , 65 ). Sudoscan assesses sudomotor function, an indirect index of sympathetic cholinergic non-myelinated C-fiber activity since sweat glands lack parasympathetic innervation ( 65 ).…”

Section: Diagnosismentioning

confidence: 99%

Postural orthostatic tachycardia syndrome and other related dysautonomic disorders after SARS-CoV-2 infection and after COVID-19 messenger RNA vaccination

Gómez-Moyano,

Rodríguez-Capitán,

Gaitán Román

et al. 2023

Front. Neurol.

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The COVID-19 pandemic has caused a challenge for our society due to the post-acute sequelae of the disease. Persistent symptoms and long-term multiorgan complications, known as post-acute COVID-19 syndrome, can occur beyond 4 weeks from the onset of the COVID-19 infection. Postural orthostatic tachycardia syndrome (POTS) is considered a variety of dysautonomia, which is characterized by chronic symptoms that occur with standing and a sustained increase in heart rate, without orthostatic hypotension. POTS can lead to debilitating symptoms, significant disability, and impaired quality of life. In this narrative review, the etiopathogenic basis, epidemiology, clinical manifestations, diagnosis, treatment, prognosis, and socioeconomic impact of POTS, as well as other related dysautonomic disorders, after COVID-19 infection and SARS-CoV-2 postvaccination, were discussed. After a search conducted in March 2023, a total of 89 relevant articles were selected from the PubMed, Google Scholar, and Web of Science databases. The review highlights the importance of recognizing and managing POTS after COVID-19 infection and vaccination, and the approach to autonomic disorders should be known by all specialists in different medical areas. The diagnosis of POTS requires a comprehensive clinical assessment, including a detailed medical history, physical examination, orthostatic vital signs, and autonomic function tests. The treatment of POTS after COVID-19 infection or vaccination is mainly focused on lifestyle modifications, such as increased fluid and salt intake, exercise, and graduated compression stockings. Pharmacotherapy, such as beta-blockers, fludrocortisone, midodrine, and ivabradine, may also be used in selected cases. Further research is needed to understand the underlying mechanisms, risk factors, and optimal treatment strategies for this complication.

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“…In fact, the genomic characterization of SARS-CoV-2 demonstrated an 88% resemblance to the bat-derived severe acute respiratory syndrome (SARS)-like coronaviruses, a 79% resemblance to the severe acute respiratory syndrome (SARS-CoV), and a 50% resemblance to the Middle East respiratory syndrome coronavirus (MERS-CoV) [4]. Despite its high mortality rate, SARS-CoV-2 causes a wide range of clinical presentations, including but not limited to psychiatric disorders, neurological disorders, endocrine disorders, respiratory disorders, and kidney disorders [5][6][7][8][9][10][11][12][13][14][15]. It has also been reported that there is a high risk of developing renal disorders, even in patients with mild COVID-19 [16,17].…”

Section: Introductionmentioning

confidence: 99%

The Role of Extracellular Vesicles in SARS-CoV-2-Induced Acute Kidney Injury: An Overview

Bernal,

How-Volkman,

Spencer

et al. 2024

Life

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The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions worldwide since its outbreak in the winter of 2019. While extensive research has primarily focused on the deleterious respiratory effects of SARS-CoV-2 in recent years, its pan-tropism has become evident. Among the vital organs susceptible to SARS-CoV-2 infection is the kidney. Post SARS-CoV-2 infection, patients have developed coronavirus disease 19 (COVID-19), with reported incidences of COVID-19 patients developing acute kidney injury (AKI). Given COVID-19’s multisystemic manifestation, our review focuses on the impact of SARS-CoV-2 infection within the renal system with an emphasis on the current hypotheses regarding the role of extracellular vesicles (EVs) in SARS-CoV-2 pathogenesis. Emerging studies have shown that SARS-CoV-2 can directly infect the kidney, whereas EVs are involved in the spreading of SARS-CoV-2 particles to other neighboring cells. Once the viral particles are within the kidney system, many proinflammatory signaling pathways are shown to be activated, resulting in AKI. Hence, clinical investigation of urinary proinflammatory components and total urinary extracellular vesicles (uEVs) with viral particles have been used to assess the severity of AKI in patients with COVID-19. Remarkedly, new emerging studies have shown the potential of mesenchymal stem cell-derived EVs (MSC-EVs) and ACE2-containing EVs as a hopeful therapeutic tool to inhibit SARS-CoV-2 RNA replication and block viral entry, respectively. Overall, understanding EVs’ physiological role is crucial and hopefully will rejuvenate our therapeutic approach towards COVID-19 patients with AKI.

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Demonstrating new-onset or worsened sudomotor function post-COVID-19 on comparative analysis of autonomic function pre-and post-SARS-CoV-2 infection

Cited by 7 publications

References 13 publications

COVID-19-induced gastrointestinal autonomic dysfunction: A systematic review

COVID-19-induced gastrointestinal autonomic dysfunction: A systematic review

Postural orthostatic tachycardia syndrome and other related dysautonomic disorders after SARS-CoV-2 infection and after COVID-19 messenger RNA vaccination

The Role of Extracellular Vesicles in SARS-CoV-2-Induced Acute Kidney Injury: An Overview

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