Demography and clinical outcome of pulmonary tuberculosis in Kashmir; 2 year prospective study

Koul, Ajaz Nabi; Wagay, Hilal Ahmad; Rather, Aadil Bashir; Dhobi, Gh Nabi; Bhat, Fayaz Ahmad; Bhat, Mohd Rafiq

doi:10.1016/j.ejcdt.2015.12.015

Cited by 2 publications

(3 citation statements)

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“…In this context, patients with smear-positive pulmonary TB are defined as experiencing treatment failure if a positive smear result is detected after 2 months or 5 months of treatment [ 5 ]. Similar studies in Hamburg and south India have revealed treatment failure rates of 2.3% and 2%, respectively [ 13 , 23 ], while higher values have been reported in Russia and Turkey (8%) [ 24 , 25 ] and lower values have been reported in Ethiopia (0.4%) and Switzerland (0.8%) [ 26 , 27 ]. Interestingly, we observed that patients who experienced treatment failure had been re-treated using the same first-line anti-TB drugs, which could worsen their health and outcomes, as well as lead to drug resistance [ 2 ].…”

Section: Discussionmentioning

confidence: 58%

Evaluating treatment outcomes and durations among cases of smear-positive pulmonary tuberculosis in Yemen: a prospective follow-up study

Jaber

Khan

Sulaiman

2017

J of Pharm Policy and Pract

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BackgroundEvaluating outcomes after tuberculosis (TB) treatment can help identify the primary reasons for treatment success or failure. However, Yemen has a treatment success rate that remains below the World Health Organization’s target. This study aimed to identify factors that were associated with unsuccessful treatment and prolonged treatment (>1 year).MethodNewly diagnosed cases of smear-positive pulmonary TB were prospectively followed at two centers (Taiz and Alhodidah, Yemen) between April 2014 and March 2015. Standardized forms were used to obtain information from the patients regarding their socio-demographic and clinical characteristics, treatment duration, and TB-related information. Multivariate logistic regression analyses were performed to identify factors that were associated with unsuccessful treatment and prolonged treatment (>1 year).ResultsThe study included data from 273 cases of newly diagnosed TB, with treatment being successful in 227 cases (83.1%) and unsuccessful in 46 cases (16.9%). Among the 46 patients with unsuccessful treatment, 29 patients (10.6%) stopped treatment, 6 patients (2.2%) transferred to another facility, 6 patients (2.2%) experienced treatment failure, and 5 patients (1.8%) died. The multivariate logistic regression analyses revealed that unsuccessful treatment was associated with female sex, illiterate status, and the presence of comorbidities. Prolonged treatment durations were associated with living in a rural area, smoking, chewing khat, a cough that lasted for >3 weeks at the beginning of treatment, and bilateral cavities during radiography.ConclusionThese results confirm that the treatment success rate in Yemen is lower than the World Health Organization’s target for smear-positive pulmonary tuberculosis. Targeting the risk factors that we identified may help improve treatment outcomes. Furthermore, it may not be prudent to re-treat patients using first-line TB drugs after an initial treatment failure.

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Section: Discussionmentioning

confidence: 58%

Evaluating treatment outcomes and durations among cases of smear-positive pulmonary tuberculosis in Yemen: a prospective follow-up study

Jaber

Khan

Sulaiman

2017

J of Pharm Policy and Pract

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“…The same study reported delayed presentation, and improper diagnosis under field conditions in smear-negative cases are responsible for the decreased incidence of a favorable outcome in low HIV areas. They recommend a more intense training of medical students' involvement in the RNTCP [21][22][23] .…”

Section: Discussionmentioning

confidence: 99%

“…Then the patients were divided into two groups as follows (a) Group I: TB patients without hypertension and (b) Group II: TB patients with hypertension. Further TB was diagnosed byAFB positive in sputum smear: either more than 2 sputum smear examination should give positive for AFB or one sputum smear with positive for AFB and radiological abnormalities with active tuberculosis 22 . All patients were subjected to the following investigations: (i) total blood count, (ii) complete biochemistry,(iii) lung function test, (iv) urine examination, (v) Chest X-ray, (vi) electrocardiogram, (vii) ultrasound sonogram abdomen, (viii)AFB sputum culture, (ix) blood pressure (x) blood glucose level, (xi) creatinine level and (xii) forced expiratory volume in first second (FEV1).…”

Section: Methodsmentioning

confidence: 99%

Comparison of Demographic, Laboratory Parameters and Clinical Outcomes Among Tuberculosis Patients With and Without Hypertension in Kanpur at Tertiary Care Teaching Hospital

Kumar¹,

Parimalakrishnan²,

Mujahid³

et al. 2019

Int. Res. J. Pharm.

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Background: Tuberculosis (TB) is a major global health problem and one of the top 10 causes of death worldwide. Aim: To compare the demographic characteristics, laboratory parameters and clinical outcomes of TB patients with and without hypertension (HTN) at a tertiary care teaching hospital. Methodology: A prospective cross-sectional study involving 220 patients divided into two groups with 95 patients from group I without HTN and 125 patients from group II with HTN. The study was conducted in the outpatient department of TB and chest medicine ward in a tertiary care teaching hospital. Results: The demographic data shows that males were affected. The economic status was similar in a group with Group I including 55%, 29.4% & 14.6% of subjects from poor, middle and rich economic status respectively and group II including 56.8%, 26.4% and 16.8% of subjects from poor, middle and rich economic status respectively. The study shows that alcohol consumption is a major risk factor in both groups. Chest X-ray, Mantoux test and sputum test was done almost for all subjects. Conclusion: From the present study we conclude that among selected demographic parameters and metabolic disorders were higher among patients with TB and HTN when compared with TB alone group. Smoking is the major risk factor-induced significant changes in functions of pulmonary and cavitary among both the group patients. The therapeutic goal was achieved for the group is attained faster when compared with the other group of patients, but both groups treatment was above 85% against the WHO statement. Adherence to therapeutic regimen was found to be satisfactory.

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Demography and clinical outcome of pulmonary tuberculosis in Kashmir; 2 year prospective study

Cited by 2 publications

References 9 publications

Evaluating treatment outcomes and durations among cases of smear-positive pulmonary tuberculosis in Yemen: a prospective follow-up study

Evaluating treatment outcomes and durations among cases of smear-positive pulmonary tuberculosis in Yemen: a prospective follow-up study

Comparison of Demographic, Laboratory Parameters and Clinical Outcomes Among Tuberculosis Patients With and Without Hypertension in Kanpur at Tertiary Care Teaching Hospital

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