Demographics of paediatric renal replacement therapy in Europe: a report of the ESPN/ERA–EDTA registry

Chesnaye, Nicholas C.; Bonthuis, Marjolein; Schaefer, Franz; Groothoff, Jaap W.; Verrina, Enrico; Heaf, James; Jankauskienė, Augustina; Lukosiene, Viktorija; Молчанова, Е. А.; Mota, Conceição; Peco-Antić, Amira; Rätsch, Ilse-Maria; Bjerre, Anna; Roussinov, Dimitar; Сукало, А. В.; Topaloğlu, Rezan; Hoeck, Koen Van; Zagożdżon, Ilona; Jager, Kitty J.; Stralen, Karlijn J. van

doi:10.1007/s00467-014-2884-6

Cited by 136 publications

(109 citation statements)

References 19 publications

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“…In fact, the two regions with better social and economic indicators (South and Southeast) were those with the best renal transplantation numbers in this collection of data. These results support the concept that efficiency in kidney transplants in children is linked to macroeconomic indicators, with more transplants in more affluent regions, an observation that has also been made in developed countries such as the US and Europe [18][19][20]. Another interesting point revealed in the multivariable analysis is that the possible effect of the number of transplant centers per million population had a lower influence on the outcome in a model containing region, age, and GDP.…”

Section: Resultssupporting

confidence: 74%

Inequality in pediatric kidney transplantation in Brazil

et al. 2015

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Section: Resultssupporting

confidence: 74%

Inequality in pediatric kidney transplantation in Brazil

et al. 2015

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“…[5][6][7] Data from national and regional renal registries in Europe show that CAKUT are the leading cause of endstage renal disease (ESRD) in children, accounting for 41.3% of children that receive renal replacement therapy (RRT). 8 Data from the European Renal AssociationEuropean Dialysis and Transplant Association Registry consisting of >200,000 patients undergoing RRT, revealed that the estimated median age of RRT initiation was 31 and 61 years in patients with and without CAKUT, respectively. 9 The age of onset of RRT was lowest in patients with renal dysplasia (16 years) and generally varied within CAKUT sub-phenotypes.…”

Section: Introductionmentioning

confidence: 99%

Genetic, environmental, and epigenetic factors involved in CAKUT

et al. 2015

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Congenital anomalies of the kidney and urinary tract (CAKUT) refer to a spectrum of structural renal malformations and are the leading cause of end-stage renal disease in children. The genetic diagnosis of CAKUT has proven to be challenging due to genetic and phenotypic heterogeneity and incomplete genetic penetrance. Monogenic causes of CAKUT have been identified using different approaches, including single gene screening, and gene panel and whole exome sequencing. The majority of the identified mutations, however, lack substantial evidence to support a pathogenic role in CAKUT. Copy number variants or single nucleotide variants that are associated with CAKUT have also been identified. Numerous studies support the influence of epigenetic and environmental factors on kidney development and the natural history of CAKUT, suggesting that the pathogenesis of this syndrome is multifactorial. In this Review we describe the current knowledge regarding the genetic susceptibility underlying CAKUT and the approaches used to investigate the genetic basis of CAKUT. We outline the associated environmental risk factors and epigenetic influences on CAKUT and discuss the challenges and strategies used to fully address the involvement and interplay of these factors in the pathogenesis of the disease.

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“…Whereas McDonald et al [178] reported a slightly lower mortality rate of 4.8 per 100 patient-years among children receiving Pediatric Nephrology DOI 10.1007/978-3-642-27843-3_62-1 # Springer-Verlag Berlin Heidelberg 2015 hemodialysis than among those receiving PD (5.9 %), survival rates of age-matched patients treated in Italy either with PD or with hemodialysis [286] and of those reported by Wong et al [316], by the United States Renal Data System [278] and by the European pediatric renal replacement therapy registry (ESPN/ ERA-EDTA registry [58]), did not differ between the two modalities.…”

Section: Patient and Technique Survivalmentioning

confidence: 92%

Peritoneal Dialysis in Children

Patel

Kv³

et al. 2015

Pediatric Nephrology

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In children with chronic kidney disease stage 5D peritoneal dialysis (PD) remains the dialysis modality most commonly prescribed, especially as automated PD. Nowadays it can be started from the first days of life on, and applied even to some preterm babies. This chapter gives an overview on PD membrane ultrastructure and function, on technical prerequistes of PD, on optimal PD prescription and on specific treatment targets and tools to monitor efficacy. It describes PD related infectious and noninfectious complications, long term peritoneal and systemic sequelae and current state of the art of how these can be mitigated or even be prevented.

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Demographics of paediatric renal replacement therapy in Europe: a report of the ESPN/ERA–EDTA registry

Abstract: Considerable variation exists in the current demographics of children treated with RRT across Europe.

Cited by 136 publications

References 19 publications

Inequality in pediatric kidney transplantation in Brazil

Inequality in pediatric kidney transplantation in Brazil

Genetic, environmental, and epigenetic factors involved in CAKUT

Peritoneal Dialysis in Children

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