Demographics, management and survival of patients with malignant pleural mesothelioma in the National Lung Cancer Audit in England and Wales

Beckett, Paul; Edwards, John; Fennell, Dean A.; Hubbard, Richard; Woolhouse, I.; Peake, Michael

doi:10.1016/j.lungcan.2015.03.005

Cited by 102 publications

(106 citation statements)

References 14 publications

(7 reference statements)

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“…In 2015, Beckett et al published data from 8740 mesothelioma cases included in the National Lung Cancer Audit 3 . This is the largest prospectively collected case series in the literature.…”

Section: Section 8: Factors Determining Prognosis and Timing Of Treatmentioning

confidence: 99%

See 1 more Smart Citation

British Thoracic Society Guideline for the investigation and management of malignant pleural mesothelioma

Woolhouse

Bishop

Darlison

et al. 2018

Thorax

170

216

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Section: Section 8: Factors Determining Prognosis and Timing Of Treatmentioning

confidence: 99%

“…The largest dataset of MPM in the UK comes from the National Lung Cancer Audit report, which described 8740 cases seen in hospitals in England and Wales between 2008 and 2012 3 . Eighty-three per cent of patients were male and the median age at diagnosis was 73 years.…”

Section: Section 1: Introductionmentioning

confidence: 99%

British Thoracic Society Guideline for the investigation and management of malignant pleural mesothelioma

Woolhouse

Bishop

Darlison

et al. 2018

Thorax

170

216

View full text Add to dashboard Cite

“…Despite efforts to reduce exposure to asbestos fibers in many countries, the long latency between exposure and development of disease ensures MPM will continue to be a significant global health burden [3]. The prognosis of MPM remains poor with median survival ranging from 8 to 14 months following diagnosis [4, 5]. …”

Section: Introductionmentioning

confidence: 99%

Catheter Tract Metastasis in Mesothelioma Patients with Indwelling Pleural Catheters: A Retrospective Cohort Study

et al. 2018

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Background: Use of indwelling pleural catheters (IPCs) for the management of symptomatic pleural effusions in patients with mesothelioma has increased in popularity. An important concern with this approach is the potential for the development of catheter tract metastasis (CTM). Objectives: To determine the incidence of IPC-related CTM in patients with malignant pleural mesothelioma (MPM). Methods: In this single-center retrospective cohort study, patients with biopsy-confirmed MPM who had an IPC inserted between May 2006 and July 2017 were identified from a prospectively collected database. Thoracic CT scans following IPC insertion were reviewed to assess for evidence of CTM. Patients were followed until death or last documented patient encounter with a minimum of 6-month follow-up. Results: A total of 90 patients were included in the cohort. CTM was identified in 23 of 90 patients (26%). Median time from IPC insertion to CTM was 408 days (interquartile range 196–721 days). Medical thoracoscopy at the time of IPC insertion did not lead to a significantly increased odds of CTM (OR 2.30; 95% CI 0.66–7.94; p = 0.19). Incidence of CTM was not different between mesothelioma subtypes (p = 0.09). Patient-reported dyspnea scores were improved following IPC insertion in 80% of patients. Conclusions: CTM was identified in over a quarter of MPM patients when follow-up imaging was reviewed. Treating physicians should be cognizant of the possibility of CTM at the site of prior IPC.

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“…By 2020-2030 and beyond, in industrialized nations alone, the increase is likely to affect thousands of people (12). For the foreseeable future, the prevalence of MPM remains a significant cancer type and the incidence continues to increase worldwide, making mesothelioma a major international health problem (12,13).…”

Section: Introductionmentioning

confidence: 99%

In vitro experimental models of mesothelioma revisited

Singh

Pruett

Hoang

2017

Transl. Lung Cancer Res.

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Demographics, management and survival of patients with malignant pleural mesothelioma in the National Lung Cancer Audit in England and Wales

Cited by 102 publications

References 14 publications

British Thoracic Society Guideline for the investigation and management of malignant pleural mesothelioma

British Thoracic Society Guideline for the investigation and management of malignant pleural mesothelioma

Catheter Tract Metastasis in Mesothelioma Patients with Indwelling Pleural Catheters: A Retrospective Cohort Study

In vitro experimental models of mesothelioma revisited

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