Demographic,Histopathological Patterns and Clinical profile of Oral Squamous Cell Carcinoma (OSCC) at a tertiary level referral Hospital in Vidarbha ( Central India) : A 7-year Retrospective Study

Abstract

Oral cancers are one of the leading cancers in the world.However ,in India,it is one of the most common cancer and a major public health problem.The purpose of this study was to evaluate retrospectively the demographics,histopathological and clinical profile of patients with oral cancer reported at a tertiary level referral hospital in Central India.A total of 908 biopsy proven OSCC cases were retrospectively analyzed and data was collected for a period of 7 years from January 2007 to December 2013 with reference to age,sex,site involved,habits,TNM staging and final diagnosis based on histopathological findings and the results were formulated to chart the trends in central India population.Male to female ratio was 2.54 : 1. Most of the patients of OSCC were in the age group of 51-60 years (28.52%) .The most common site of presentation of primary tumor was mandibular alveolus region.Tobacco chewing along with smoking was the major cause for the development of OSCC(25.66%).Majority of the patients were presented in Stage IV (45.94%) and histopathologically well differentiated squamous cell carcinoma(54.95%) was the most common presentation.This study showed that OSCC is wide spread in the patients of this region and most of the cases report at advanced stages of the disease due to lack of awareness among the common masses.To decrease the morbidity and mortality associated with OSCC ,early detection of localized lesions combined with appropriate treatment is required.

Trends and clinicopathological characteristics of oral squamous cell carcinomas reported at a tertiary cancer hospital in Nepal during 1999 to 2009

“…In line with this, the mean age for OSCCs was 55 years in our study, an age group considered as a risk group of OC (Zini, Czerninski, & Sgan‐Cohen, ). This result is in accordance with several other studies from different demographic groups (Alves et al, ; Malhotra et al, ).…”

“…OSCC was more frequent in males than in females, similar to a recent report by GLOBOCAN (IARC, ) and studies from the neighboring country India (Malhotra et al, ; Salian, Dinakar, Shetty, & Ajila, ). The higher number of OSCCs among males might be related to higher percentage of males using tobacco products (betel quid and tobacco chewing) and alcohol than women, as suggested by previous reports (Lee et al, ).…”

“…In developing countries like Nepal, the diagnosis of OSCC at an advanced stage is common (Chettri, Bhandary, Singh, Sinha, & Karki, ; Malhotra et al, ). Likewise, more than two thirds of the patients were found to be at Stages III and IV in this study.…”

Expression of GLUT-1 in oral squamous cell carcinoma in tobacco and non-tobacco users

“…21,22 In our study 76% cases were above the age of 40 years and males were predominant (74%). Similar findings were observed by Malhotra et al, 23 Shyam Sunder et al 24 and Doshi Neena et al 25 Tobacco addiction group consisted 92.30% males and only 7.70% females. High proportion of cases among males may be due to tobacco consumption in them.…”

Can increased metabolic status be a grading tool for oral squamous cell carcinoma? A glucose transporter 1 immunoexpression study

“…Gender difference though present, with the male population being 69.7%, no statistically significant difference was observed. A higher predominance OSCC in male was in accordance with studies reported by Ayala et al [11] and Malhotra et al [12] In contrast, Harshani et al [13] reported a higher female predominance.…”