Demographic features and histopathological diagnosis in primary eyelid tumors: results over 19 years from a tertiary center in Ankara, Turkey

Eren, Mehtap Arslantürk; Gündüz, Ahmet Kaan

doi:10.18240/ijo.2020.08.16

Cited by 11 publications

(16 citation statements)

References 24 publications

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“…BCC is more common in the lower eyelid (50-66%), followed by medial canthus (10-30%), upper eyelid (15-16%), and lateral canthus (3-5%). ere was no preference for upper or lower eyelids of SqCC [31,57]. Medial canthus (48%) and lower eyelid (32%) was the most frequent involved site for BCC [51,58,59].…”

Section: Discussionmentioning

confidence: 97%

“…e reported age range of the patients was 11 years to 94 years, and about 45% of the patients were aged between 60 and 70 years [31]. e incidence of BCC is higher in people over 60 years of age [31]. A prevalence of male gender was reported in patients with BCC [32,[50][51][52][53].…”

Section: Discussionmentioning

confidence: 98%

“…Eyelid malignancy accounts for 19.5% (332 cases) in this study. In the United States and Europe, BCC (85-95%) is the most common eyelid carcinoma, whereas others eyelid malignancies accounts 5-15% [2,6,10,[29][30][31][32].…”

Section: Discussionmentioning

confidence: 99%

“…Malignant eyelid tumors are rare in children and young adults but occur more commonly in the sixth, seventh, and eighth decades of life [12, 37, 38, 43-45, 48, 49]. e reported age range of the patients was 11 years to 94 years, and about 45% of the patients were aged between 60 and 70 years [31]. e incidence of BCC is higher in people over 60 years of age [31].…”

Section: Discussionmentioning

confidence: 99%

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Clinicopathological Analysis and Surgical Outcome of Eyelid Malignancies: A Study of 332 Cases

Kadir¹,

Mitra

Rashid³

et al. 2022

Journal of Skin Cancer

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Background. Eyelid tumours are common in our ophthalmic practice. Malignancy cases account only for one-fourth of all eyelid tumours. The most aggressive eyelid malignancy is sebaceous gland carcinoma, but its occurrences are rare in western countries. We found sebaceous gland carcinoma is as common as basal cell carcinoma in our clinical practices. Hence, it is essential to build awareness about the more aggressive eyelid malignancies to reduce morbidity and mortality. Aim. To assess the relative frequency of eyelid malignancies in the Bangladesh population, state their clinical features and outcome of management strategies and build awareness about the more aggressive eyelid malignancies to reduce morbidity and mortality. Methods. This was a retrospective case series study of 332 patients in Bangladesh. This study analyzed all the recorded data of the histologically proven primary eyelid malignancies and followed them up for at least six months from 2014 to 2019 (6 years). All patients were managed by surgical excision with tumor-free margins verified on histopathology, either the frozen section or excision biopsy with 2–3 mm microscopic view of normal tissue followed by eyelid reconstruction. Computer-based statistical software SPSS was used for the analysis, and an appropriate test of significance (chi-square) was used for the statistical analysis. Results. Sebaceous gland carcinoma (SGC) was the highest in occurrence, at 42%, followed by 38% basal cell carcinoma (BCC), 18% squamous cell carcinoma (SqCC), and 02% malignant melanoma (MM). The mean age at presentation of SGC, BCC, SqCC, and MM were 57.41 years, 62.56 years, 64.73 years, and 59.28 years, respectively. Female (59%) was slightly more preponderance over the male (41%) for SGC than other malignancies. Pigmentation was associated with malignant melanoma (100%) and BCC (81%). Statistically, a significant difference was found between eyelid malignancies, including location, size, pigmentation, recurrence, and invasiveness. The recurrence rate was low lower in the patients who underwent frozen section biopsy (3%) for margin clearance than those who underwent excision biopsy (21.5%) in the follow-up time. Conjunctival map biopsy (8%) was performed as an essential tool for excluding the pagetoid spread of SGC. A new reconstruction method named triangular-shaped musculocutaneous tail flap was performed in 33 (11%) patients to reconstruct the moderate eyelid defect following local resection. Conclusion. Sebaceous gland carcinoma (SGC) was the highest occurrence found to be the highest occurrence among all eyelid malignancies in Bangladesh. SGC is more aggressive and the recurrence rate was higher than BCC and SqCC.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Clinicopathological Analysis and Surgical Outcome of Eyelid Malignancies: A Study of 332 Cases

Kadir¹,

Mitra

Rashid³

et al. 2022

Journal of Skin Cancer

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“…1 Eyelid malignant tumors were accounting for more than 20% of all eyelid tumors. 2,3 Malignant eyelid neoplasms often required wide excision to ensure complete excision of the tumor. Mohs micrographic surgery (MMS) is the gold standard for treating a variety of cutaneous conditions.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological features of patients with wide local excision of eyelid malignant neoplasms: a more than five years retrospective study from China

Han

Kong

Luo

et al. 2022

Preprint

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Background: To investigate the correlation between the clinical and pathological characteristics and outcomes in patients with eyelid malignant tumors underwent wide local excision.Methods: This retrospective study included 141 cases of eyelid malignant neoplasms from January 2010 to December 2015 in Shanxi eye hospital. Demographic and clinical information were collected. The Kaplan-Meier method was used to calculate survival curves, and the log-rank test method was used to compare survival between groups. Cox proportional regression models were used to calculate the hazard ratios (HR) of total recurrence rate and metastasis rate.Results: Overall, there were 141 eyelid malignant neoplasms cases aged 65.00 ± 9.69 (range, 41 - 88) years old. The duration time range was from 1 to 828 (61.09 ± 122.21) months. Basal cell carcinoma (BCC) is the most common of all eyelid malignancies, accounting for 84 (59.5%), followed by Sebaceous gland carcinoma (SGC, 41, 29%), Squamous Cell Carcinoma (SCC, 11, 7.8%), Malignant Melanoma (MM, 3, 2.1%)。On cox-regression analysis, pathological classification (HR 1.959; 95% CI 1.012-3.790; p=0.046) and eyelid tumor surgery history (HR 17.168; 95% CI 1.889-156.011; p=0.012) were independently associated with recurrence in patients with eyelid malignant neoplasm. Pathological classification (HR 2.177; 95% CI 1.423 -3.331; p<0.001) was independently associated with metastasis in patients with eyelid malignant neoplasm. Recurrence and metastasis were most likely to occur in 3 years after surgery. Conclusion: Wide local excision is an effective and economical treatment for eyelid malignant neoplasms. The prognosis is mainly related to pathological types, eyelid tumor surgical history and TNM stages.

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Sebaceous hyperplasia of the eyelid: A comprehensive case report and literature review

Ma,

Liu,

et al. 2024

Heliyon

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Demographic features and histopathological diagnosis in primary eyelid tumors: results over 19 years from a tertiary center in Ankara, Turkey

Cited by 11 publications

References 24 publications

Clinicopathological Analysis and Surgical Outcome of Eyelid Malignancies: A Study of 332 Cases

Clinicopathological Analysis and Surgical Outcome of Eyelid Malignancies: A Study of 332 Cases

Clinicopathological features of patients with wide local excision of eyelid malignant neoplasms: a more than five years retrospective study from China

Sebaceous hyperplasia of the eyelid: A comprehensive case report and literature review

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