Demographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri Lanka

Agampodi, Suneth; Warnasekara, Janith; Siribaddana, Sisira; Kularatna, SAM; Gamage, Chandika D.; Jayasundara, Dinesha; Senavirathna, Indika; Srimantha, Shalka; Kappagoda, Chamila; Weerawansa, Prasanna; Pilapitiya, Senaka; Lokunarangoda, Niroshan; Sarathchandra, Chamara; Senanayake, Hemal; Matthias, Michael; Vinetz, Joseph M.

doi:10.1016/j.dib.2022.108378

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…Standard patient recruitment steps are as follows. Seeking standard patients through word-of-mouth strategies (by contacting other standard clients, contacting standard clients with coaches) (Agampodi et al, 2022;Mendiola et al, 2022). Assign the role to the right person in each case (both appearance, psychological, availability and no contraindications).…”

Section: Discussionmentioning

confidence: 99%

Analisis Pemetaan Kesesuaian Ujian Keterampilan Klinis di Program Studi Kedokteran di Bali

Giri

Lasmawan

Putra

2022

j. pendidik. indonesia.

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Analisis Pemetaan Kesesuaian Ujian Keterampilan Klinis di Program Studi Kedokteran di Bali Made Kurnia Widiastuti Giri1, I Wayan Lasmawan2, Adnyana Putra 31,3 Kedoketran, Universitas Pendidikan Ganesha, Singaraja2Pendidikan Kewarganegaraan, Universitas Pendidikan Ganesha, Singarajae-mail: AbstrakPembelajaran bidang kedokteran merupakan pendidikan yang mengacu pada tujuan pembelajaran keilmuwan dan keterampilan. Indikator penilaian dalam ujian keterampilan klinis terukur dalam daftar penilaian keterampilan. Indikator dalam penilaian keterampilan klinis ditetapkan berdasarkan standar kompetensi yang telah ditetapkan. Ujian keterampilan klinis dirancang dan dilaksanakan oleh program studi kesehatan termasuk di dalamnya program studi ilmu kedokteran. Program studi ilmu kesehatan seyogyanya melaksanakan pembelajaran dengan keseragaman pola dalam kurikulum yang diterapkan. Tujuan penelitian ini adalah untuk menganalisis permasalahan dala pelaksanaan ujian keterampialn klinis prodi kedokteran di Bali. Hasil penelitian ini memperoleh deskripsi lengkap tentang kebutuhan dalam keberhasilan pelaksanaan ujian Objective Structure Clinical Skills Examination (OSCE) di prodi kedokteran se-Bali dengan metode deskriptif kualitatif sebagai langkah awal pengembangan model ujian OSCE yang bertujuan meningkatkan kemampuan kompetensi ketrampilan klinis mahasiswa. Penelitian ini menyajikan data deskriptif kualitatif secara terstruktur dalam sajian data yang diperoleh melalui narasi tahapan persiapan, pelaksanaan dan evaluasi pelaksanaan OSCE. Sebagai kesimpulan dari penelitian ini adalah belum adanya pola yang sama antara prodi kedokteran dikarenakan belum adanya kegiatan review kurikulum sehingga keseragaman dalam pelaksanaan OSCE belum dapat dilaksanakan secara maksimal. Penelitian ini memberikan rekomendasi lebih lanjut kepada prodi kedokteran untuk melkauakn review kurikulum bersama karena dengan mereview secara bersama maka kompetensi setiap lulusan dari prodi kedokteran universitas yang berbeda akan berada dalam kategori setara.Kata kunci: Ujian Keterampilan Klinis, OSCE, Kedokteran

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Section: Discussionmentioning

confidence: 99%

Analisis Pemetaan Kesesuaian Ujian Keterampilan Klinis di Program Studi Kedokteran di Bali

Giri

Lasmawan

Putra

2022

j. pendidik. indonesia.

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“…The blood samples combined with EMJH media for cultivation were then placed in an incubator set at 30 °C for incubation [1] , A culture collection was conducted involving three categories of patients. This included individuals who had acute undifferentiated fevers (with temperatures exceeding 38 °C) and sought medical care in the adult wards (aged over 13 years) of Teaching Hospital Anuradhapura(THA), THP, Provincial General Hospital Rathnapura (PGHR), as well as Base Hospital Avissawella (BHA), encompassing both outpatients and those hospitalized, who were considered potential cases of leptospirosis [2] , and clinical details [3] are published elsewhere. Leptospira weilii strains, FMAS_PD2 and FMAS_RT1, were isolated from samples collected in Peradeniya and Rathnapura, and Leptospira kirschneri FMAS_PN5 was isolated from samples collected in Polonnaruwa, Sri Lanka.…”

Section: Experimental Design Materials and Methodsmentioning

confidence: 99%

Whole genome sequencing data of Leptospira weilii and Leptospira kirschneri isolated from human subjects of Sri Lanka

Senavirathna,

Jayasundara,

Warnasekara

et al. 2024

Data in Brief

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Genomic Analysis of Human-infectingLeptospira borgpeterseniiisolates in Sri Lanka: expanded PF07598 gene family repertoire, less overall genome reduction than bovine isolates

Senavirathna,

Jayasundara,

Warnasekara

et al. 2024

Preprint

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Leptospira borgpetersenii commonly causes human leptospirosis, including severe disease. The first published analysis of L. borgpetersenii, performed on two strains of serovar Hardjo (L550 and JB197), concluded that the L. borgpetersenii genome is in the process of genome decay with functional consequences leading to a more obligately host-dependent life cycle. Yet whole genome analysis has only been carried out on few strains of L. borgpetersenii, with limited closed genomes and comprehensive analysis. Herein we report the complete, circularized genomes of seven non-Hardjo Leptospira borgpetersenii isolates from human leptospirosis patients in Sri Lanka. These isolates (all ST144) were found to be nearly identical by whole genome analysis; serotyping showed they are a novel serovar. We show that the L. borgpetersenii isolated from humans in Sri Lanka are less genomically decayed than previously reported isolates: fewer pseudogenes (N=141) and Insertion Sequence (IS) elements (N=46) compared to N=248, N=270, and N=400 pseudogenes, and N=121 and N=116 IS elements in published L. borgpetersenii Hardjo genomes (L550, JB197 and TC112). Compared to previously published L. borgpetersenii whole genome analyses showing two to three VM proteins in L. borgpetersenii isolates from cattle, rats and humans, we found that all of the human L. borgpetersenii isolates from Sri Lanka, including previously reported serovar Piyasena, have 4 encoded VM proteins, one ortholog of L. interrogans Copenhageni LIC12339 and 3 orthologs of LIC12844. Our findings of fewer pseudogenes, IS elements and expansion of the LIC12844 homologs of the PF07598 family in these human isolates suggests that this newly identified L. borgpetersenii serovar from Sri Lanka has unique pathogenicity. Comparative genome analysis and experimental studies of these L. borgpetersenii isolates will enable deeper insights into the molecular and cellular mechanisms of leptospirosis pathogenesis.

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Demographic, exposure, clinical, biochemical and diagnostic data of febrile patients recruited for the largest field study on leptospirosis in Sri Lanka

Cited by 3 publications

References 5 publications

Analisis Pemetaan Kesesuaian Ujian Keterampilan Klinis di Program Studi Kedokteran di Bali

Analisis Pemetaan Kesesuaian Ujian Keterampilan Klinis di Program Studi Kedokteran di Bali

Whole genome sequencing data of Leptospira weilii and Leptospira kirschneri isolated from human subjects of Sri Lanka

Genomic Analysis of Human-infectingLeptospira borgpeterseniiisolates in Sri Lanka: expanded PF07598 gene family repertoire, less overall genome reduction than bovine isolates

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