Demographic, clinical, laboratory, and genetic risk factors associated with COVID-19 severity in adults: A narrative review

Martynowicz, Helena; Jodkowska, Anna; Poręba, Rafał; Mazur, Grzegorz; Więckiewicz, Mieszko

doi:10.17219/dmp/131795

Cited by 10 publications

(11 citation statements)

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“…Additionally, patients with active hematologic malignancies seem to be at increased risk of mortality [ 35 ]. However, depending on the treatment received, some subsets of patients receiving immunomodulatory drugs, which may help avoiding the deleterious dysregulated immune response in COVID-19, might even have a better prognosis [ 36 ]. When interpreting the results of this study, it should be noted that we could only analyze the underlying conditions included in the systematic reviews detected by our strategy.…”

Section: Discussionmentioning

confidence: 99%

Association of Patients’ Epidemiological Characteristics and Comorbidities with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of an Umbrella Systematic Review and Meta-Analysis

et al. 2022

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The objective of this study was to assess the association between patients’ epidemiological characteristics and comorbidities with SARS-CoV-2 infection severity and related mortality risk. An umbrella systematic review, including a meta-analysis examining the association between patients’ underlying conditions and severity (defined as need for hospitalization) and mortality of COVID-19, was performed. Studies were included if they reported pooled risk estimates of at least three underlying determinants for hospitalization, critical disease (ICU admission, mechanical ventilation), and hospital mortality in patients diagnosed with SARS-CoV-2 infection. Evidence was summarized as pooled odds ratios (pOR) for disease outcomes with 95% confidence intervals (95% CI). Sixteen systematic reviews investigating the possible associations of comorbidities with severity or death from COVID-19 disease were included. Hospitalization was associated with age > 60 years (pOR 3.50; 95% CI 2.97–4.36), smoking habit (pOR 3.50; 95% CI 2.97–4.36), and chronic pulmonary disease (pOR 2.94; 95% CI 2.14–4.04). Chronic pulmonary disease (pOR 2.82; 95% CI 1.92–4.14), cerebrovascular disease (pOR 2.74; 95% CI 1.59–4.74), and cardiovascular disease (pOR 2.44; 95% CI 1.97–3.01) were likely to be associated with increased risk of critical COVID-19. The highest risk of mortality was associated with cardiovascular disease (pOR 3.59; 95% CI 2.83–4.56), cerebrovascular disease (pOR 3.11; 95% CI 2.35–4.11), and chronic renal disease (pOR 3.02; 95% CI 2.61–3.49). In conclusion, this umbrella systematic review provides a comprehensive summary of meta-analyses examining the impact of patients’ characteristics on COVID-19 outcomes. Elderly patients and those cardiovascular, cerebrovascular, and chronic renal disease should be prioritized for pre-exposure and post-exposure prophylaxis and early treatment.

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Section: Discussionmentioning

confidence: 99%

Association of Patients’ Epidemiological Characteristics and Comorbidities with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of an Umbrella Systematic Review and Meta-Analysis

et al. 2022

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“…Post-COVID-19 syndromes can be expected to account for a large proportion of consultations in both primary and secondary care in the near future [ 125 , 126 ]. As the pandemic does not seem to be subsiding and the world is facing a new wave of COVID-19 [ 122 ], the major challenge for the healthcare system at present is not only to manage the acute phase of SARS-CoV-2 infection but also to plan rehabilitation strategies [ 123 ].…”

Section: Long Covid Syndrome and Rehabilitationmentioning

confidence: 99%

Cardiovascular, Pulmonary, and Neuropsychiatric Short- and Long-Term Complications of COVID-19

Kobusiak−Prokopowicz

Fułek

et al. 2022

Cells

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Beginning with the various strategies of the SARS-CoV-2 virus to invade our bodies and manifest infection, and ending with the recent long COVID, we are witnessing the evolving course of the disease in addition to the pandemic. Given the partially controlled course of the COVID-19 pandemic, the greatest challenge currently lies in managing the short- and long-term complications of COVID-19. We have assembled current knowledge of the broad spectrum of cardiovascular, pulmonary, and neuropsychiatric sequelae following SARS-CoV-2 infection to understand how these clinical manifestations collectively lead to a severe form of the disease. The ultimate goal would be to better understand these complications and find ways to prevent clinical deterioration.

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“…Transmission occurs through aerosol or respiratory droplets of those infected or contact with contaminated surfaces, and its clinical picture ranges from asymptomatic cases to more severe cases, requiring hospital care for 10% to 15% of those infected 3 , 4 , 5 and with mortality rates between 1.2% and 1.6%. 6 Age is the main risk factor for disease progression, 7 including in-hospital death. 8 According to the WHO, 118 529 397 cases of COVID-19 were confirmed worldwide by March 12, 2021, leading to the death of 2 630 678 individuals.…”

Section: Introductionmentioning

confidence: 99%

Cost Utility of Vaccination Against COVID-19 in Brazil

Fernandes¹,

Santos²,

Magliano³

et al. 2022

Value in Health Regional Issues

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Demographic, clinical, laboratory, and genetic risk factors associated with COVID-19 severity in adults: A narrative review

Cited by 10 publications

References 0 publications

Association of Patients’ Epidemiological Characteristics and Comorbidities with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of an Umbrella Systematic Review and Meta-Analysis

Association of Patients’ Epidemiological Characteristics and Comorbidities with Severity and Related Mortality Risk of SARS-CoV-2 Infection: Results of an Umbrella Systematic Review and Meta-Analysis

Cardiovascular, Pulmonary, and Neuropsychiatric Short- and Long-Term Complications of COVID-19

Cost Utility of Vaccination Against COVID-19 in Brazil

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