Demographic, clinical characteristics, psychological profiles, treatment and follow-up of gastroparesis

Soykan, İrfan; Sarosiek, Irene; Sıvrı, Bülent; McCallum, Richard W.

doi:10.1016/s0016-5085(98)83424-0

Cited by 192 publications

(394 citation statements)

References 0 publications

Supporting

Mentioning

347

Contrasting

Unclassified

Order By: Relevance

“…1 Nausea and vomiting are present in 70-90% of patients with gastroparesis, 2,3 and, in addition to being the most bothersome symptoms reported by patients, 4 contribute to multiple health issues, [5][6][7] including electrolyte disturbances and dehydration, and increased healthcare utilisation. 8 These symptoms may also decrease work performance and ability to function socially.…”

Section: Resultsmentioning

confidence: 99%

Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting - randomised clinical study subset data

Ejskjær²,

Hellström

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting - randomised clinical study subset data

Ejskjær²,

Hellström

et al. 2011

Alimentary Pharmacology &Amp; Therapeutics

View full text Add to dashboard Cite

show abstract

“…in systemic sclerosis (scleroderma) 3 . Many cases are idiopathic 4 . In fact, in one highly referenced study by Soykan et al published in 1998 in the Digestive Diseases and Sciences journal, no specific cause could be identified in approximately one-half of patients with delayed gastric emptying in various reports.…”

Section: Figure 1: Lead I Ecg Of Jc Demonstrating Loss Of Respiratomentioning

confidence: 99%

“…In fact, in one highly referenced study by Soykan et al published in 1998 in the Digestive Diseases and Sciences journal, no specific cause could be identified in approximately one-half of patients with delayed gastric emptying in various reports. 4 Diabetic gastroparesis may occur in people with type 1 or 2 diabetes. Studies, mostly surveys, among Caucasians with diabetes showed that 5 -12% of patients had symptoms that were attributable to gastroparesis.…”

Section: Figure 1: Lead I Ecg Of Jc Demonstrating Loss Of Respiratomentioning

confidence: 99%

Case Report-The 46 year old man with a 5 month history of vomiting

Segula¹,

Mwandiambira²,

Howson³

et al. 2011

Mal. Med. J

View full text Add to dashboard Cite

MalawiOn the 23rd of January 2011, we admitted a 46-year-old man to Queen Elizabeth Central Hospital (QECH) with a 5-month history of recurrent vomiting. This was associated with nausea. He would vomit at least 5 times per day. The vomitus was non-projectile, would usually take the colour of the food eaten and was never bilious. There was no history of abdominal pain, dysphagia, fever or headache. The colour of stools was normal but he had complained of constipation for 6 days prior to admission. He also admitted to weight loss, which could not be quantified. Prior to attending QECH he had been seen in several health facilities and had been treated with promethazine, but had had no relief of his symptoms. An endoscopy done at another hospital was documented as follows: 'endoscopy shows reflux oesophagitis and lax lower oesophageal sphincter' There was no comment on whether there were structural abnormalities at the level of the pylorus or duodenum. He had been diagnosed with type 2 diabetes mellitus in December 2010 on the basis of high random blood glucose readings. He had been prescribed glibenclamide but stopped as he felt it was making him vomit more, and was now only taking metformin. Blood glucose measurements since the start of treatment were not available so we do not know how well the diabetes had been controlled. He had a history of moderate alcohol consumption (< 20 units per week) but had not taken alcohol since the symptoms started. He had no history of smoking. He was HIV negative. He used to work as a foreman for a construction company but had stopped work owing to the severity of his symptoms. He was married with 3 children. There was no family history of diabetes. On examination, he was moderately cachexic and dehydrated. His blood pressure (BP) was 130/80 mmHg, temperature 37oC, pulse 92/minute, respiratory rate 28/minute. His conjunctivae were pink, there were no oral lesions and he had no lymphadenopathy, including Virchow's node. Chest examination was normal. Abdominal examination was normal except there were hard stools in the rectum. His fundoscopy showed dot and blot haemorrhages, consistent with background diabetic retinopathy. His random blood glucose concentration was 252mg/dl and there were no ketones in his urine. Blood potassium and sodium were 3.1 mmol/L (3.6 -5.0) and 127 mmol/L (135 -145) respectively. He had a normal blood creatinine and no proteinuria. Discussion 1) Causes of vomiting can be divided into gastrointestinal causes, central causes and metabolic causes. In this case the causes of vomiting that should be considered include gastrointestinal causes such as achalasia, gastric malignancy, pyloric stenosis, gastric or duodenal ulcer, gastroparesis and generalized motility disorders such as intestinal myopathies and neuropathies. Central causes include migraine, cyclical vomiting, psychogenic vomiting, space occupying lesions and labyrinthitis. Metabolic causes such as drugs, hypercalcaemia and hyponatraemia should also be considered. 2)A careful history and examination ar...

show abstract

“…It is a heterogeneous disorder in which different etiologies may impact symptoms or response to treatment. The most common etiologies of gastroparesis include diabetes and postsurgical, followed by neurologic, rheumatologic and other miscellaneous disorders [2]. However, the etiology is unknown in approximately 40% of patients with gastroparesis, a condition identified by idiopathic gastroparesis.…”

Section: Introductionmentioning

confidence: 99%

Therapeutic Applications of Ghrelin Agonists in the Treatment of Gastroparesis

Shin

2015

Curr Gastroenterol Rep

View full text Add to dashboard Cite

There remains an unmet need for effective pharmacologic treatments for gastroparesis.Ghrelin is the endogenous ligand for the growth hormone secretagogue receptor and has been shown to regulate energy homeostasis and exert prokinetic effects on gastrointestinal motility. In recent years, several ghrelin receptor agonists have been studied in clinical trials of patients with diabetic gastroparesis. The intravenous macrocyclic peptidomimetic, TZP-101 initially suggested improvement in gastroparesis symptoms with intravenous administration when compared to placebo. However, in subsequent studies of oral preparations, TZP-102 failed to confirm these results. Another ghrelin receptor agonist, RM-131 was recently shown to significantly accelerate gastric emptying (GE) in patients with type 1 and type 2 diabetes and delayed GE. RM-131 reduced total Gastroparesis Cardinal Symptom Index-Daily Diary (GCSI-DD) and composite scores among type 1 diabetics. Continued development of ghrelin agonists should be explored in attempts to expand therapeutic options for the treatment of gastroparesis.

show abstract

Demographic, clinical characteristics, psychological profiles, treatment and follow-up of gastroparesis

Cited by 192 publications

References 0 publications

Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting - randomised clinical study subset data

Randomised clinical trial: ghrelin agonist TZP-101 relieves gastroparesis associated with severe nausea and vomiting - randomised clinical study subset data

Case Report-The 46 year old man with a 5 month history of vomiting

Therapeutic Applications of Ghrelin Agonists in the Treatment of Gastroparesis

Contact Info

Product

Resources

About