Demographic and socioeconomic predictors of treatment delays, pathologic stage, and survival among patients with penile cancer: A report from the National Cancer Database

Attalla, Kyrollis; Paulucci, David; Blum, Kyle A.; Anastos, Harry; Moses, Kelvin A.; Badani, Ketan K.; Spiess, Philippe E.; Sfakianos, John P.

doi:10.1016/j.urolonc.2017.09.014

Cited by 24 publications

(27 citation statements)

References 24 publications

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“…4,15 The commonest histological type identifi ed in most of the studies is squamous cell carcinoma. 6,14 Similarly in the present study 98% of the patients had SCC. Other histological types found in our study were basal cell carcinoma and melanoma are the rare fi ndings.…”

Section: Bpkmch Nepalese Journal Of Cancer (Njc)supporting

confidence: 81%

“…Other histological types found in our study were basal cell carcinoma and melanoma are the rare fi ndings. 14,16 Moreover, well to moderately differentiated pathology is more common compared to poorly differentiated/ anaplastic disease. 17,18 The treatment modalities for penile cancer include surgery, chemotherapy and radiotherapy.…”

Section: Bpkmch Nepalese Journal Of Cancer (Njc)mentioning

confidence: 99%

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A Retrospective Analysis of Carcinoma Penis Patients Treated at a Cancer Center in Nepal in a Period of Five Years

et al. 2019

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Introduction: Carcinoma Penis is not an uncommon condition in a developing country like Nepal and comprises 1-10% of all the malignancies in males. In this study we analyzed the demographic and clinicopathological profile of penile cancer patients who visited our cancer center during specified period. Methods: This is a descriptive cross-sectional study, that altogether included 218 patients from January 2012 to December 2016 with penile cancer conducted at B P Koirala Memorial Cancer Hospital, Nepal. All the demographic and clinico-pathological data were collected and analyzed using SPSS 16.0 software. Tumor staging was standardized according to the American Joint Committee on Cancer system. Quantitative data were represented as mean and standard deviation whereas categorical variables were expressed as frequencies and percentages of an appropriate denominator. Results: Among 218 patients, the mean ± SD age was 53.94 ± 13.69 years. Most were married (88.07%), smokers (67.88%), had poor personal hygiene (70.64%) and had not completed primary school (71.64%). The predominant profession was agriculture (81.65%). Most of the patients (56.88%) were diagnosed in clinical stage III b (T1-3, N2). Management was circumcision alone in 5.5%, Wide local excision in 6.88%, partial penectomy in 66.97% patients, total penectomy with perineal urethrostomy in 11% of patients and 9.63% patients were sent for chemotherapy after initial biopsy for fixed and fungating inguinal nodes. Bilateral inguinal lymph node dissection was performed in 87.15% patients. Most of our patients were uncircumcised (90.82%) Squamous cell carcinoma was the commonest histopathology (98.6%). Conclusion: Penile cancer is more common among farmer with low socioeconomic status. The disease is already locally advanced and at the time of diagnosis. Surgery is the main modality of treatment.

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Section: Bpkmch Nepalese Journal Of Cancer (Njc)supporting

confidence: 81%

Section: Bpkmch Nepalese Journal Of Cancer (Njc)mentioning

confidence: 99%

A Retrospective Analysis of Carcinoma Penis Patients Treated at a Cancer Center in Nepal in a Period of Five Years

et al. 2019

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“…Certain socio‐economic factors were excluded from our analysis, including facility type and location, insurance status, income, education level and Charlson comorbidities. While studies do show that these factors are associated with staging, oncological outcomes and overall survival, they are related not to the aggressiveness of the tumour, but to social factors that influence access to care . The median (range) age at diagnosis was 63 (23–90) years.…”

Section: Resultsmentioning

confidence: 99%

“…Prior studies have shown that racial disparities do exist for the treatment and prognosis of penile cancer. Two studies that used the NCDB found that black race was associated with higher tumour stage at diagnosis and lower overall survival . However, neither demonstrated black race as a significant predictor of node‐positive disease.…”

Section: Discussionmentioning

confidence: 99%

A National Cancer Database‐based nomogram to predict lymph node metastasis in penile cancer

et al. 2019

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ObjectiveTo evaluate the predictive nature of several clinicopathological variables by developing a nomogram predictive for lymph node-positive disease using the National Cancer Database cohort of patients with squamous cell carcinoma of the penis. MethodsStepwise logistic regression was used to find the best-fit model; remaining clinical variables were used to create a nomogram to predict the probability of lymph node-positive disease. ResultsOn multivariate analysis, high pathological grade (3-4 vs 1: odds ratio [OR] 3.27, 95% confidence interval [CI] 1.70-6.29; 2 vs 1: OR 2.58, 95% CI 1.39-4.79 [P = 0.002]), lymphovascular invasion (OR 2.49, 95% CI 1.61-3.84 [P < 0.001]), and positive clinical lymph node status (N1 vs N0: OR 20.0, 95% CI 11.4-35.7; N2 vs N0: OR 27.8, 95% CI 14.1-55.6; N3 vs N0: OR 49.2, 95% CI 14.8-162.8 [P < 0.001]) were predictors of lymph node metastasis in penile cancer. The bootstrap-corrected concordance index of this nomogram was 0.880. ConclusionUsing tumour grade, tumour lymphovascular invasion and clinical lymph node status, we developed a nomogram highly predictive of pathologial lymph node metastasis that, after further external validation, could be helpful in the surgical decision-making process.

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“…Cancer death rates vary considerably by level of education [22]. Kyrollis Attalla et al found that penile cancer patients with low education levels were more likely to be diagnosed with a worse pathologic T stage [23]. Ki-Tae Hwang et al found that high education levels conferred a superior prognosis for breast cancer patients in the subgroup aged > 50 years; these patients had a lower mean age at the first diagnosis and more favorable biological features [24].…”

Section: Discussionmentioning

confidence: 99%

Education Level as a Predictor of Survival in Patients with Multiple Myeloma

Wang²,

Pan

et al. 2020

Preprint

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Background Disparities in multiple myeloma (MM) prognosis based on sociodemographic factors may exist. We investigated whether education level at diagnosis influenced Chinese MM patient outcomes.Methods We performed a multicenter retrospective analysis of data from 773 MM patients across 9 centers in China from 2006 to 2019. Sociodemographic and clinical factors at diagnosis and treatment regimens were recorded, and univariate and multivariate analyses were performed. Results Overall, 69.21% of patients had low education levels. Patients with low education levels differed from those with high education levels in that they were more likely to be older, and a higher proportion lived in rural areas, were unemployed, had lower annual incomes and lacked insurance. Additionally, compared to patients with high education levels, patients with low education levels had a higher proportion of international staging system (ISS) stage III classification and elevated lactate dehydrogenase (LDH) levels and underwent transplantation less often. Patients with high education levels had better progression-free survival (PFS) and overall survival (OS) than did patients with low education levels (67.50±8.10 versus 30.60±1.64 months; 122.27±0 versus 55.83±3.55 months, log-rank test, p<0.001; respectively). In the multivariable analysis, patients with high education levels had lower relapse and mortality rates than did those with low education level in terms of PFS and OS (hazard ratio (HR)=0.50 [95% confidence interval (CI): 0.34-0.72], p<0.001; HR=0.31 [0.18-0.53], p<0.001, respectively). Conclusions Low education levels may independently predict poor survival in MM patients in China. To reduce healthcare disparities for universal healthcare reform, it is critical to improve citizens’ education levels.

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Demographic and socioeconomic predictors of treatment delays, pathologic stage, and survival among patients with penile cancer: A report from the National Cancer Database

Cited by 24 publications

References 24 publications

A Retrospective Analysis of Carcinoma Penis Patients Treated at a Cancer Center in Nepal in a Period of Five Years

A Retrospective Analysis of Carcinoma Penis Patients Treated at a Cancer Center in Nepal in a Period of Five Years

A National Cancer Database‐based nomogram to predict lymph node metastasis in penile cancer

Education Level as a Predictor of Survival in Patients with Multiple Myeloma

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