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Purpose: This study investigated the occurrence of keratoconus among first-degree relatives of patients with keratoconus and evaluated their refractive characteristics. Method: A cross-sectional observational study was conducted on 248 relatives of 52 patients with keratoconus in whom bilateral eye analysis was conducted. Corneal tomography was performed for all participants with a comprehensive analysis of various parameters, including K1, K2, Kmax, elevation, skewing, and thinnest location. In addition, the following data were also analyzed: uncorrected visual acuity, corrected distance visual acuity, refraction measurements alongside a slit-lamp examination, and fundus examination. Results: Among 248 participants, 19 (7.7%) had keratoconus, 3.2% had forme fruste, and 15.3% had suspected keratoconus. Among all studied cases, 73.8% had normal corneas. Significant differences (P = 0.001) were found in the distribution of keratoconus prevalence among brothers, mothers, sons, and sisters (13.6%, 4.3%, 5.6%, and 12.1%, respectively). The presence of refractive errors also showed significant differences between the relatives (P = 0.03). Conclusions: Increased keratoconus prevalence among relatives of patients with keratoconus indicates the vulnerability of this population to the development of the disease, necessitating early screening of this group for detection of keratoconus as early as possible.
Purpose: This study investigated the occurrence of keratoconus among first-degree relatives of patients with keratoconus and evaluated their refractive characteristics. Method: A cross-sectional observational study was conducted on 248 relatives of 52 patients with keratoconus in whom bilateral eye analysis was conducted. Corneal tomography was performed for all participants with a comprehensive analysis of various parameters, including K1, K2, Kmax, elevation, skewing, and thinnest location. In addition, the following data were also analyzed: uncorrected visual acuity, corrected distance visual acuity, refraction measurements alongside a slit-lamp examination, and fundus examination. Results: Among 248 participants, 19 (7.7%) had keratoconus, 3.2% had forme fruste, and 15.3% had suspected keratoconus. Among all studied cases, 73.8% had normal corneas. Significant differences (P = 0.001) were found in the distribution of keratoconus prevalence among brothers, mothers, sons, and sisters (13.6%, 4.3%, 5.6%, and 12.1%, respectively). The presence of refractive errors also showed significant differences between the relatives (P = 0.03). Conclusions: Increased keratoconus prevalence among relatives of patients with keratoconus indicates the vulnerability of this population to the development of the disease, necessitating early screening of this group for detection of keratoconus as early as possible.
BackgroundKeratoconus (KC) is a non-inflammatory corneal disease with an early onset in adulthood, leading to a reduction in visual acuity. This study aims to evaluate the level of awareness of keratoconus among the general population in the Hail region of Saudi Arabia. MethodologyData were collected through a pre-designed and pre-validated online questionnaire (Appendix) distributed via social media platforms. The questionnaire was divided into two sections. The first section included demographic profiles, while the second section inquired about knowledge and awareness regarding Keratoconus. The collected data was reviewed, coded, and inputted into IBM Corp. Released 2013. IBM SPSS Statistics for Windows, Version 22.0. Armonk, NY: IBM Corp. Statistical analyses were performed using the Pearson Chi-Square test, with statistical significance set at p<0.05. ResultsThe total number of respondents was 550, among whom 40% were males and 60% were females. 79.6% of the participants were in the age range of 18-30 years. The level of education and a positive family history of KC showed significant associations with the level of knowledge about KC (p<0.05). The age group had a nonsignificant association (p=0.059), while gender had a significant association with the level of knowledge about keratoconus (p<0.05). ConclusionIn conclusion, the overall awareness regarding KC progression, interventions, and the consequences of eye rubbing was limited among the participants. Specific efforts are crucial to enhance public awareness and understanding of KC, ensuring a more informed and proactive approach to eye health within the community.
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