Demographic and Clinical Profile in Patients with Liver Cirrhosis in a Tertiary Care Hospital in Central Nepal

Abstract

Introduction: Liver cirrhosis is an important health problem worldwide and is a common disease in Nepal. The profile of cirrhosis may vary due to different factors. This study was undertaken to see the demographic and clinical profiles of patients with cirrhosis of liver attending a tertiary care hospital in Central Nepal.
 Methods: Six hundred patients with clinical features, laboratory and sonological findings suggestive of chronic liver dysfunction and endoscopic evidence of portal hypertension were included in the study. Their demographic and clinical profile, endoscopic findings, outcomes during hospitalization were studied. Ethical approval was taken from Institutional Review Committee of College of Medical Sciences. SPSS 20 was used for statistical analysis.
 Results: The mean age of subjects was 54±11.84 years with 435 males (72.5%) and 165 (27.5%) females. Majority of 203 (33.8%) patients were from Mongol ethnicity followed by 127 (21.2%) Khas. Two hundred and twenty (36.6%) were farmers followed by 169 (28.2%) retired personnel. A total of 338 (56.4 %) patients were from rural areas. The commonest aetiology of cirrhosis was chronic alcohol consumption and seen in 552 (92%) patients. Abdominal distension was commonest presenting sign and observed in 561 (93.5%) patients. Ascites seen in 555 (92.5%) patients was the commonest complication followed by UGI bleed in 326(54.3%) patients. Gastro-oesophageal varices observed in 345 (57.5%) patients, was the most common endoscopic finding followed by portal gastropathy, peptic ulcer and erosive mucosal diseases. In patient mortality was noted in 92 (15.3 %) patients.
 Conclusions: This study highlights the burden of cirrhosis, usually caused by chronic alcohol consumption in Central Nepal. Majority of subjects were male, middle aged, farmers, from rural areas and predominantly observed in some ethnicity like Mongols. Cirrhotic patients usually present late with varied complications and have high mortality.
 
 Keywords: cirrhosis of liver; complications; endoscopy.

The Assessment of Health-Related Quality of Life in Patients With Chronic Liver Disease: A Single-Center Study

“…We discovered that CLD due to chronic alcohol consumption (75%) was the most common cause of the disease. This finding is consistent with the study by Bhattarai et al [ 12 ] conducted in the central part of Nepal.…”

Clinical Profile and Upper Gastrointestinal Endoscopic Findings of Patients Presenting with Liver Cirrhosis with Portal Hypertension

“…This is similar to results seen in other studies where males were involved in 72.5% and 80.7%respectively. [16][17] The trend of alcohol intake is more in men as compared to women, as men have easy access and are lesser judged on a social basis regarding their alcohol consumption. Furthermore, male dominance in our society might have led to males getting more access to hospitalization and treatment as compared to females.…”

Profil Klinis Pasien Sirosis Hati dengan Varises Esofagus yang Menjalani Ligasi Varises Esofagus di Rumah Sakit Dr. Cipto Mangunkusumo

“…Sedangkan studi oleh Bhattarai, dkk. 13 di Nepal menunjukkan bahwa 58,3% pasien SH berusia > 50 tahun. 13 Etiologi SH tersering pada studi ini adalah hepatitis B (51,8%).…”

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“…Begitu pula studi yang dilakukan oleh Bhattarai, dkk. 13 Sebanyak 52 pasien menjalani EGD karena perdarahan saluran cerna, 40 pasien menjalani ligasi VE, dan 12 pasien tidak menjalani ligasi VE. Dari 40 pasien yang mengalami perdarahan saluran cerna dan menjalani ligasi VE tersebut didapatkan 23 pasien tidak mempunyai riwayat tindakan ligasi maupun konsumsi propranolol.…”