Demographic and Clinical Features Related to a Symptomatic Onset of Paget’s Disease of Bone

Varenna, M.; Zucchi, F.; Galli, Laura; Manara, Maria Cristina; Marco, Gabriele De; Sinigaglia, Luigi

doi:10.3899/jrheum.090674

Cited by 14 publications

(5 citation statements)

References 25 publications

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“…Headache as the first symptom has been reported at 0.9% of all PDB patients and at 1.6% of the symptomatic population 21 , but the exact incidence at long-term course of the disease is still unknown 9 . Symptomatic patients usually have more pelvic or spine involvement, than skull or facial lesions 22 .…”

Section: Approach Considerationsmentioning

confidence: 99%

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Headache in patients with Paget’s Disease of Bones

Evangelatos

Iliopoulos

2017

JFSF

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Section: Approach Considerationsmentioning

confidence: 99%

“…Elevated serum alkaline phosphatase (SAP) levels are connected to polyostotic disease 21 and, thus, make head involvement more possible. Patients with PDB of skull have been reported to have higher baseline bone turnover markers 22 .…”

Section: Approach Considerationsmentioning

confidence: 99%

Headache in patients with Paget’s Disease of Bones

Evangelatos

Iliopoulos

2017

JFSF

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“…The disease is often polyostotic, but in up to 50% of cases, it can be monostotic. 6,13,15 Typically, in a long bone, PD extends from one end of the bone with a flame-shaped advancing margin. This margin can progress, but the rate of progression is very variable and sometimes can be as little as 1 mm per year.…”

Section: Pathologymentioning

confidence: 99%

Paget Disease of Bone

Lalam

Cassar‐Pullicino

Winn

2016

Semin Musculoskelet Radiol

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Paget disease (PD) is a common disease of bone associated with abnormal bone turnover that in turn is due to an imbalance between osteoclastic and osteoblastic activity. There is good evidence that PD is reducing in incidence, prevalence, and severity. The disease is most often asymptomatic and is usually detected incidentally on imaging examinations performed for other reasons. The features of PD are relatively specific on radiographs and computed tomography. However, the appearances on magnetic resonance imaging are subtle and nonspecific, although it has become the initial imaging choice for several clinical indications including back pain, neurologic dysfunction, and knee pain. It is therefore important to be familiar with the various imaging appearances of this relatively common disease in an increasingly aging population. In this article we discuss the various imaging appearances of PD and its complications.

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“…It begins with excess osteoclast activity or resorption followed by osteoblast activity laying down disordered, mosaic bone that is larger and less compact [4,5]. It begins with excess osteoclast activity or resorption followed by osteoblast activity laying down disordered, mosaic bone that is larger and less compact [4,5].…”

Section: Patient Bmentioning

confidence: 99%

“…Bone ALP concentrations in blood are increased 10-25 times the upper limit in Paget's disease [5,68]. Osteoblasts build bone and also produce bone ALP.…”

Section: Bone Diseasementioning

confidence: 99%

4. Alkaline phosphatase

Schmidt¹

2014

Diagnostic Enzymology

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A 35-year-old male presents to his primary care physician with complaints of fatigue, pruritus, abdominal pain, fevers, weight loss, and intermittent jaundice. Over the past 6 months he has lost 10 kg and his pruritus has been getting increasingly worse. He denies shortness of breath and his appetite has not changed. He has had some diarrhea that is occasionally associated with blood. He has not had any changes in his vision or hearing. He has never smoked and only drinks 2-3 beers on the weekends. He has never used illicit drugs and is married with one child. His father, paternal grandmother, and sister all have ulcerative colitis.Physical examination shows a thin male with scleral icterus and pale mucus membranes. His vital signs are normal, but he has a systolic ejection murmur. He has hepatomegaly with the edge of the liver being 5 cm below the costal margin. Upon examining his skin, excoriations are seen on his arms, legs, chest, and back.Laboratory tests performed on blood collected at his office visit show: hemoglobin 91 g/L, hematocrit 27%, white blood cell count 9.8 ×

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Demographic and Clinical Features Related to a Symptomatic Onset of Paget’s Disease of Bone

Abstract: A systematic laboratory screening including serum alkaline phosphatase of an older subject complaining of bone pain, articular pain, or back pain is the sole strategy to improve the diagnostic sensitivity for PDB.

Cited by 14 publications

References 25 publications

Headache in patients with Paget’s Disease of Bones

Headache in patients with Paget’s Disease of Bones

Paget Disease of Bone

4. Alkaline phosphatase

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