Demographic and Clinical Features of ANCA-Associated Vasculitides in a Peruvian Tertiary Center

Pimentel-Quiroz, Víctor R.; Sánchez-Torres, Alfredo; Acevedo‐Vásquez, Eduardo; Gamboa-Cárdenas, Rocío V.; Reátegui-Sokolova, Cristina; Medina-Chinchón, Mariela; Zevallos, Francisco; Noriega-Zapata, Erika; Alfaro-Lozano, José; Cucho-Venegas, Jorge M.; Sánchez-Schwartz, César; Rodríguez-Bellido, Zoila; Perich-Campos, Risto; Pastor-Asurza, C.A.; Alarcón, Graciela S.; Ugarte‐Gil, Manuel F.

doi:10.1097/rhu.0000000000001595

Cited by 10 publications

(43 citation statements)

References 31 publications

(107 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Thickett et al 27 described that approximately 5% of patients with GPA presented respiratory failure; in our case, this percentage was slightly higher, at 7.14%; in addition, as expected, 27 patients with EGPA were the only ones that presented asthma, in the same way that alveolar hemorrhage was the second most present manifestation in patients with MPA. A recent cohort from Peru reported a similar trend to us regarding organ involvement, with respiratory manifestations in first place (61.3%), of which the main manifestation was interstitial lung disease in 76.9% of them 21 …”

Section: Discussionsupporting

confidence: 76%

“…Antineutrophil cytoplasmic ANCA–associated vasculitides have been mainly reported in adult populations, with a peak incidence between ages approximately 50 and 70 years 6,20,21 . Our patients were between this range, with a median age of 52 (40–64) years at the time of diagnosis; however, although the condition is rare in children, it has been reported, with female predominance in the second decade of life 22 .…”

Section: Discussionmentioning

confidence: 60%

“…In terms of disease activity, the BVAS was calculated for every patient at diagnosis. Eosinophilic granulomatosis with polyangiitis showed a median score of 10 (8-10); GPA, 12 (10)(11)(12)(13)(14)(15)(16)(17)(18); and MPA, 21 (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25). Birmingham Vasculitis Activity Score was recorded at baseline, and a significant difference was seen between GPA and EGPA (p = 0.005).…”

Section: Resultsmentioning

confidence: 98%

See 2 more Smart Citations

Clinical Characteristics and Outcomes of Patients With ANCA-Associated Vasculitides in a Colombian Hospital

et al. 2021

View full text Add to dashboard Cite

Background/Objective: Antineutrophil cytoplasmic antibody-associated vasculitides (AAVs) are uncommon systemic autoimmune diseases, of which few reports exist in Latin America. Our aim was to examine AAV evaluated in a high-complexity hospital in southwestern Colombia, with emphasis in severe forms. Methods:A medical records review study of 67 patients was performed, and data were collected from electronic registries. Moderate and severe AAVs were defined as the presence of life-threatening complications, unfavorable Birmingham Vasculitis Activity Score outcomes, and hospitalization requirements at the time of diagnosis and by the last follow-up, between 2011 and 2019. Clinical manifestations, treatment, and outcomes were evaluated. The AAV subtypes were compared.Results: A total of 67 cases were included. The majority were female (n = 44, 65.67%), and the median age was 52 (40-64) years. Granulomatosis with polyangiitis (GPA) was the most frequent with 42 patients (62.68%), followed by microscopic polyangiitis (MPA) and eosinophilic GPA, with 15 patients (22.38%) and 10 patients (14.92%), respectively. Forty-four patients (65.67%) presented pulmonary symptoms. The highest Birmingham Vasculitis Activity Score corresponded to MPA, with 21 (12-25) points. Fifteen patients (22.4%) were admitted to the intensive care unit throughout the course of the disease, of whom 10 had GPA. The longest stay and duration of mechanical ventilation were seen in MPA. The principal treatments were corticosteroids and cyclophosphamide, and the main outcome was end-stage renal disease. Conclusions:In this cohort of AAV, most of cases corresponded to GPA, and pulmonary manifestations were the most common. Microscopic polyangiitis was the more severe subtype as it showed worse impairment in clinical characteristics and intensive care unit requirements.

show abstract

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 98%

See 1 more Smart Citation

Clinical Characteristics and Outcomes of Patients With ANCA-Associated Vasculitides in a Colombian Hospital

et al. 2021

View full text Add to dashboard Cite

show abstract

“…Other groups have reported higher BVAS scores at presentation in sub-Saharans and Afro-Caribbean's with GPA and Hispanic patients. 4,[11][12][13] Likewise, we did not observe any differences in clinical outcomes such as need for dialysis or death. Differences in disease severity and consequent outcomes can be affected by a variety of external factors, which include discrimination, health care access and use, occupation type, low education and income, and poor housing conditions.…”

Section: Discussionmentioning

confidence: 86%

Clinical Features of ANCA-Associated Vasculitis in African American Patients in the United States

Palomino

Gaffo²,

Sun³

et al. 2022

J Clin Rheumatol

View full text Add to dashboard Cite

Background/Purpose: The aim of this study was to compare the clinical features at presentation of ANCA-associated vasculitis (AAV) between African American (AA) and White patients.Methods: This is a chart review of cases between January 2003 and December 2018. African American patients with AAV were identified and matched in a 1:2 ratio with White comparators based on the year of diagnosis (±4 years). Data on demographics, clinical, and laboratory features and outcomes at presentation were collected. Descriptive statistics were used to compare the characteristics between groups.Results: Thirty-two of 56 AA patients with AAV had complete data and were included for analysis. When compared with 64 matched White patients with AAV, AA patients were younger (47.5 vs 61.0 years, p = 0.001). Compared with White patients, AA patients with granulomatosis with polyangiitis (GPA) (35 vs 55 years, p = 0.0006) and microscopic polyangiitis (MPA) (55.5 vs 65.0 years, p = 0.05) were younger. African American patients with GPA were more frequently female ( p = 0.008), whereas AA patients with MPA were more frequently male ( p = 0.03). No differences in disease manifestations, disease activity, and outcomes were observed between AA and White patients with AAV. Conclusions:In this single-center study, AA patients with AAV were diagnosed at a younger age than Whites; this was found in both the GPA and MPA disease phenotypes. No other significant differences were observed. Future studies are needed to confirm our findings and better describe differences of AAV in racial/ethnic minorities.

show abstract

“…The characteristics of the patients and their predictive factors of survival have been described in detail in previous publications. 6,7 We performed a review of the medical records of patients with AAV followed at this clinic between January 1990 and December 2019. Antineutrophil cytoplasmic antibody-associated vasculitis was diagnosed by experienced rheumatologists based on the 1990 ACR criteria, the 2012 CHCC definitions, the EMEA algorithm, and their experience and clinical acumen.…”

Section: Methodsmentioning

confidence: 99%

Performance of the 2017 American College of Rheumatology/European League Against Rheumatism Provisional Classification Criteria for Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in a Peruvian Tertiary Care Center

et al. 2021

Self Cite

View full text Add to dashboard Cite

To validate the new classification criteria for antineutrophil cytoplasmic antibody-associated vasculitis in a real-life Peruvian cohort of antineutrophil cytoplasmic antibody-associated vasculitis patients. Methods:We reviewed medical records from a Peruvian tertiary care center from January 1990 to December 2019. Antineutrophil cytoplasmic antibody-associated vasculitis was diagnosed based on the 1990 American College of Rheumatology (ACR) criteria, the 2012 Chapel Hill Consensus Conference definitions, the European Medicines Agency (EMEA) algorithm, and the clinical acumen of the treating rheumatologists. We classified all patients using the "former criteria" (the 1990 ACR criteria for granulomatosis with polyangiitis [GPA] and eosinophilic GPA [EGPA] and the 1994 Chapel Hill Consensus Conference definition for microscopic polyangiitis [MPA]), the EMEA algorithm, and the "new criteria" (the 2017 ACR/European League Against Rheumatism Provisional Criteria). The level of agreement (using Cohen κ) was calculated using the clinical diagnosis as the criterion standard. Results:We identified 212 patients, 12 of whom were excluded. One hundred fifty-four (77%) had MPA, 41 (20.5%) GPA, and 5 (2.5%) EGPA. The new criteria performed well for MPA (κ = 0.713) and EGPA (κ = 0.659), whereas the EMEA algorithm performed well for GPA (κ = 0.938). In the overall population, the new criteria showed better agreement (κ = 0.653) than the EMEA algorithm (κ = 0.506) and the former criteria (κ = 0.305). Conclusions:The 2017 ACR/European League Against Rheumatism Provisional Criteria showed better agreement for the clinical diagnosis of all the patients overall and had the best performance for MPA and EGPA. The EMEA algorithm had the best performance for GPA.

show abstract

Demographic and Clinical Features of ANCA-Associated Vasculitides in a Peruvian Tertiary Center

Cited by 10 publications

References 31 publications

Clinical Characteristics and Outcomes of Patients With ANCA-Associated Vasculitides in a Colombian Hospital

Clinical Characteristics and Outcomes of Patients With ANCA-Associated Vasculitides in a Colombian Hospital

Clinical Features of ANCA-Associated Vasculitis in African American Patients in the United States

Performance of the 2017 American College of Rheumatology/European League Against Rheumatism Provisional Classification Criteria for Antineutrophil Cytoplasmic Antibody–Associated Vasculitis in a Peruvian Tertiary Care Center

Contact Info

Product

Resources

About