Demographic and clinical characteristics of primary glomerular diseases in Turkey

Öztürk, Savaş; Şumnu, Abdullah; Seyahi, Nurhan; Güllülü, Mustafa; Sipahioğlu, Murat Hayri; Artan, Serra; Bicik, Zerrin; Kutlay, Sim; Keleş, Mustafa; Oygar, Deren; Odabaş, Ali Rıza; Kayataş, Mansur; Dursun, Belda; Sayarlıoğlu, Hayriye; Trablus, Sinan; Taymez, Dilek Güven; Özdemir, Ali; Şahin, Gülizar Manga; Altun, Bülent; Azak, Alper; Altıntepe, Lütfullah; Süleymanlar, Gültekin; Koç, Mehmet; Yılmaz, Selçuk; Kazancıoğlu, Rümeyza; Erkoç, Reha; Gürsu, Meltem; Küçük, Mehmet; Akcaoglu, Selma Alagoz; Yildiz, Abdülmecid; Ünal, Aydın; Akarsu, Özger; Ateş, Kenan; Çankaya, Erdem; Türkmen, Aydın

doi:10.1007/s11255-014-0838-3

Cited by 31 publications

(24 citation statements)

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“…Notably, 23.8% of elderly and 24.8% of younger patients with pauci-immune GN suffered from nephrotic-range proteinuria. Pauci-immune GN being one of the leading diagnoses made upon kidney biopsy among elderly individuals was reported by others [13, 25, 28, 29]. The peak frequency and the highest relative frequency of this disease in our patients studied occurred at the age of 55-64 years (Fig.…”

Section: Discussionsupporting

confidence: 68%

“…In a vast majority of cases pauci immune GN is associated with the presence of ANCA vasculitis, with peak incidence of 52.9 per million being observed among people aged 65–74 [30]. It is worth mentioning that in contrast to younger individuals, in the elderly vasculitis more commonly manifests with renal disease, and less frequently involves upper respiratory tract [29]. Vasculitis-related symptoms such as myalgia and headache may be easily misdiagnosed as common afflictions of the elderly, e.g., polymyalgia rheumatica [31].…”

Section: Discussionmentioning

confidence: 99%

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Kidney disease in the elderly: biopsy based data from 14 renal centers in Poland

et al. 2016

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BackgroundLonger life expectancy is associated with an increasing prevalence of kidney disease. Aging itself may cause renal damage, but the spectrum of kidney disorders that affect elderly patients is diverse. Few studies, mostly form US, Asia and West Europe found differences in the prevalence of some types of kidney diseases between elderly and younger patients based on renal biopsy findings, with varied proportion between glomerulopathies and arterionephrosclerosis as a dominant injury found. Here, for the first time in Eastern Europe we analyzed native kidney biopsy findings and their relationship to clinical characteristics at the time of biopsy in elderly individuals (aged ≥65) in comparison to younger adults (aged 18–64).MethodsBiopsy and clinical data from 352 patients aged ≥65 were retrospectively identified, analyzed and compared with a control group of 2214 individuals aged 18–64. All kidney biopsies studied were examined at Medical University of Warsaw in years 2009–14.ResultsIn elderly patients the leading indication for biopsy was nephrotic range proteinuria without hematuria (34.2%) and the most prevalent pathologic diagnoses were: membranous glomerulonephritis (MGN) (18.2%), focal segmental glomerulosclerosis (FSGS) (17.3%) amyloidosis (13.9%) and pauci immune glomerulonephritis (12.8%). Hypertension and age-related lesions very rarely were found an exclusive or dominant finding in a kidney biopsy (1.7%) and a cause of proteinuria (1.1%) in elderly individuals. There were 18.2% diabetics among elderly individuals, and as much as 75% of them had no morphologic signs of diabetic kidney disease in the renal biopsy. Amyloidosis, MGN, pauci immune GN, crescentic GN and light and/or heavy chain deposition disease (LCDD/HCDD) were more frequent whereas IgA nephropathy (IgAN), lupus nephritis (LN) and thin basement membrane disease (TBMD) were less common among elderly than in younger patients.ConclusionsProteinuria, a dominating manifestation in elderly patients subjected to kidney biopsy was most commonly related to glomerulopathies. The relatively high prevalence of potentially curative kidney diseases in elderly individuals implicates the importance of renal biopsy in these patients.Electronic supplementary materialThe online version of this article (doi:10.1186/s12882-016-0410-8) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 99%

Kidney disease in the elderly: biopsy based data from 14 renal centers in Poland

et al. 2016

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“…According to some other reports, male patients were also bioptied more frequently than female (Romanian data-51.5%; Clinical Center Serbia-51.2%; Pisa, Italy-59%; Czech data-57.9%; Turkish data-55%). The mean age at the moment of renal biopsy was almost one decade higher in our patients than in that reported by others (two Romanian Centers-38.5±15.2; Clinical Center Serbia-39.1±13.8 years, Turkey-40.8±14.6 years) (5)(6)(7)(8)(9). This difference can be explained by different attitudes regarding the biopsy of the elderly.…”

Section: Discussioncontrasting

confidence: 61%

Epidemiological Review of Kidney Biopsy during 30 years - Single Center Experience

et al. 2015

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C 12 H 22 CdN4O14, triclinic, P¯ (no. 2), a = 7.188(2) Å, b = 8.895(3) Å, c = 9.771(3) Å, α = 63.148(3)°, β = 76.750(3)°, γ = 66.225(3)°, V = 509.2(3) Å 3 , Z = 1, Rgt(F) = 0.0253, wR ref (F 2 ) = 0.0676, T = 296(2) K. CCDC no.: 1484775The crystal structure is shown in the gure. Tables 1 and 2 contain details of the measurement method and a list of the atoms including atomic coordinates and displacement parameters. Source of materialThe title compound was synthesized by a hydrothermal method under autogenous pressure. A mixture of CdCl 2 ·H 2 O

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“…As indicated in Figure , the proportion of MN increased significantly year after year. An increase in the frequency of MN has also been reported from other centres in China and other countries . Some authors have argued that the increase in MN incidence is due to an improvement in life expectancy .…”

Section: Discussionmentioning

confidence: 65%

“…A limited number of single centre studies have shown that the renal histopathological spectrum of proliferative glomerulonephritis (PGN) has continuously changed in recent years. One of these changes is the frequency of MN (15.7–29.2%), which has increased significantly . IgAN is still the most common PGD in China and other countries .…”

mentioning

confidence: 99%

Increasing prevalence of membranous nephropathy in patients with primary glomerular diseases: A cross‐sectional study in China

Tang

Yao²,

Kong

et al. 2017

Nephrology

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Demographic and clinical characteristics of primary glomerular diseases in Turkey

Cited by 31 publications

References 23 publications

Kidney disease in the elderly: biopsy based data from 14 renal centers in Poland

Kidney disease in the elderly: biopsy based data from 14 renal centers in Poland

Epidemiological Review of Kidney Biopsy during 30 years - Single Center Experience

Increasing prevalence of membranous nephropathy in patients with primary glomerular diseases: A cross‐sectional study in China

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