Demographic & Clinical Profile Analysis of Acute Viral Hepatitis E Patients in Bangladesh: A Single-Center Study

Abstract

Background: In Bangladesh, Acute hepatitis is seen sporadically round the year. On the other the other hand, the incidence of acute viral hepatitis E increases after floods as this allows sewerage contamination of piped and groundwater. Objective: In this study our main goal is to evaluate the demographic & Clinical Profile Analysis of Acute Viral Hepatitis E Patients in Bangladesh. Method: This prospective observational study was conducted in the Department of Gastroenterology, US-Bangla Medical College & Hospital during the period from July 2018 to June 2019, in Bangladesh. A total of 35 patients who were attending the Hepatology unit with acute viral hepatitis were included as the study population for this study. By enzyme-linked immunosorbent assay, all viral markers were tested. Results: Majority, 34.4% belong to 21-30 year’s age group, and 81.3% were male. Positive cases of Anti HAV IgM were 10% followed by Anti HEV IgM seen in 100%, however, none of the Anti HCV IgM seen in patients. Higher serum bilirubin was 8.82±5.65. Followed by Levels of aspartate aminotransferase (AST) was 1141.00±128.69, S.GPT ALT was 1380.75±751.28, S. Creatinine was10.00±18.33. Moreover, Prothrombin Time was seen longer in patients. Which means patient’s needs higher blood clotting time than usual. Conclusion: Acute viral hepatitis E is the leading cause of wide spectrum of liver disease in young male adults ranging from severe acute viral hepatitis, to decompensation of liver in cirrhotic in Bangladesh.