Demodicidosis simulating acute graft‐versus‐host disease after allogeneic stem cell transplantation in one patient with acute lymphoblastic leukemia

Román-Curto, Concépción; Meseguer-Yebra, C.; Cañueto, Javier; Fraile-Alonso, C.; Santos‐Briz, Ángel; Vázquez, Lourdes; Fernández‐López, Emilia

doi:10.1111/j.1399-3062.2012.00729.x

Cited by 17 publications

(24 citation statements)

References 13 publications

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“…8 Demodicosis have been described predominantly in 3 facial skin conditions: pityriasis folliculorum, rosacea-like demodicosis, and "demodicosis gravis." 17 Because Demodex mites are saprophytes in the human skin, a casual relationship with these pathologies has been controversial. 17 Because Demodex mites are saprophytes in the human skin, a casual relationship with these pathologies has been controversial.…”

Section: Introductionmentioning

confidence: 99%

Demodex Folliculitis of the Scalp: Clinicopathological Study of an Uncommon Entity

Helou¹,

Avitan‐Hersh²,

Bergman

2016

The American Journal of Dermatopathology

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Demodex is a saprophytic mite in humans commonly present in the pilosebaceous units, which has been implicated as a pathogen in several skin conditions. The clinical presentation and histopathology of Demodex folliculitis of the scalp have been described in only a few case reports. This study was performed to further elucidate the clinicopathological features of this entity. We have studied 333 consecutively submitted scalp biopsies performed for hair loss and alopecia. All specimens were completely step-sectioned. Biopsies with Demodex mites were further studied histopathologically, and the patients' clinical files were reviewed. There were 17 biopsies (5.1%) with Demodex in at least 1 pilosebaceous unit. Based on the clinical presentation, histopathology, and response to therapy, Demodex was considered to be nonpathogenic in 13 cases. The remaining 4 cases were characterized by hair loss, scalp erythema, scales, and pustules. There were 2 or more pilosebaceous units with Demodex along mononuclear and/or neutrophilic infiltrates around and in the involved follicles and occasionally granulomas. All 4 cases responded completely to metronidazole therapy. In conclusion, Demodex is infrequently found in scalp biopsies for hair loss and alopecia, and, in most cases, it does not seem to be pathogenic. Occasionally, however, it is associated with folliculitis characterized by hair loss, erythema, scales, and pustules clinically; neutrophilic and/or mononuclear-cell folliculitis with occasional granulomas histopathologically; and a prompt response to anti-Demodex therapy.

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Section: Introductionmentioning

confidence: 99%

Demodex Folliculitis of the Scalp: Clinicopathological Study of an Uncommon Entity

Helou¹,

Avitan‐Hersh²,

Bergman

2016

The American Journal of Dermatopathology

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“…18 We present 2 patients in which FM was found in the drug-related vasculitis and demodecidosis 19 after BMT for nasal-type T/NK-cell lymphoma and multiple myeloma, respectively (Fig. 19 Infectious-related FM has also been communicated in the setting of human immunodeficiency virus 20 and herpes zoster virus. Both these cases showed polyclonality, no atypical mitotic figures, no recurrences of their underlying hematologic malignancy, and lack of progression to lymphoma.…”

Section: Discussionmentioning

confidence: 98%

Follicular Mucinosis Associated With Nonlymphoid Skin Conditions

Mir-Bonafé¹,

Cañueto²,

Fernández‐López³

et al. 2013

The American Journal of Dermatopathology

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Background: Follicular mucinosis coexisting with lymphoproliferative disorders has been thoroughly debated. However, it has been rarely reported in association with inflammatory disorders.Methods: Thirteen cases have been retrieved, and those with cutaneous lymphoma or alopecia mucinosa were excluded.Results: It was found follicular mucinosis in the setting of squamous cell carcinoma, seborrheic keratosis, simple prurigo, acne vulgaris, dextrometorphan-induced phototoxicity, polymorphous light eruption (2 cases), insect bite (2 cases), tick bite, discoid lupus erythematosus, drug-related vasculitis, and demodecidosis. Unexpectedly, our observations revealed a preponderating accumulation of mucin related to photo-exposed areas, sun-associated dermatoses, and histopathologic solar elastosis. The amount of mucin filling the follicles apparently correlated with the intensity of perifollicular inflammatory infiltrate, which was present in all cases. The concurrence of dermal interstitial mucin was found in 7 cases (54%). Conclusions:The concurrence of interstitial dermal mucinosis or the potential role of both ultraviolet radiation and the perifollicular inflammatory infiltrates in its pathogenesis deserves further investigations. Precise recognition and understanding of this distinctive reactive histological pattern may prevent our patients from unnecessary diagnostic and therapeutic strategies.

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“…In cancer patients who were taking epidermal growth factor receptor inhibitors, it was reported that Demodex mite colonization was increased which increased the risk of dermatologic conditions such as annular facial eruptions. There were also reported cases of Demodex folliculitis mimicking acute cutaneous graft-versus-host disease (GVHD) 21–26. Tissue samplings of the affected skin tissue confirmed the diagnosis of Demodex in the suspected GVHD patients.…”

Section: Pathogenesismentioning

confidence: 89%

<em>Demodex </em>blepharitis: clinical perspectives

Fromstein

Harthan

Patel

et al. 2018

OPTO

109

125

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Demodex folliculorum and Demodex brevis are two mites which infest the human eye and which may, in excess, lead to a wide range of anterior segment findings. Demodex mites have been implicated in anterior and posterior blepharitis, blepharoconjunctivitis, blepharokeratitis, and beyond. Due to significant overlap with other anterior segment conditions, Demodex infestation remains underdiagnosed and undertreated. Definitive diagnosis can be made with lash sampling, and the most common mode of treatment is with tea tree oil in varying concentrations. This article summarizes elements of pathogenesis, diagnosis, and management critical to clinical care of this common condition.

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Demodicidosis simulating acute graft‐versus‐host disease after allogeneic stem cell transplantation in one patient with acute lymphoblastic leukemia

Cited by 17 publications

References 13 publications

Demodex Folliculitis of the Scalp: Clinicopathological Study of an Uncommon Entity

Demodex Folliculitis of the Scalp: Clinicopathological Study of an Uncommon Entity

Follicular Mucinosis Associated With Nonlymphoid Skin Conditions

<em>Demodex </em>blepharitis: clinical perspectives

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