Demodex y blefaritis crónica

Rodriguez, Ae; Ferrer, C; Alió, J. L.

doi:10.4321/s0365-66912005001100004

Cited by 47 publications

(13 citation statements)

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“…There are many species of Demodex , but only D. folliculorum and D. brevis are found on the human body (2). In the eye, Demodex can be found on the eyelashes, the lash follicles, and the meibomian glands, and is thought to be associated with blepharitis, allergic conjunctivitis, and pathological corneal features (2-5). Recently, a high prevalence of Demodex in eyelashes with cylindrical dandruff has been reported and a method of evaluating ocular demodecosis by sampling and counting Demodex has been introduced (6, 7).…”

Section: Introductionmentioning

confidence: 99%

Clinical and Immunological Responses in Ocular Demodecosis

2011

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The purpose of this study was to investigate clinical and immunological responses to Demodex on the ocular surface. Thirteen eyes in 10 patients with Demodex blepharitis and chronic ocular surface disorders were included in this study and treated by lid scrubbing with tea tree oil for the eradication of Demodex. We evaluated ocular surface manifestations and Demodex counts, and analyzed IL-1β, IL-5, IL-7, IL-12, IL-13, IL-17, granulocyte colony-stimulating factor, and macrophage inflammatory protein-1β in tear samples before and after the treatment. All patients exhibited ocular surface manifestations including corneal nodular opacity, peripheral corneal vascularization, refractory corneal erosion and infiltration, or chronic conjunctival inflammatory signs before treatment. After treatment, Demodex was nearly eradicated, tear concentrations of IL-1β and IL-17 were significantly reduced and substantial clinical improvement was observed in all patients. In conclusion, we believe that Demodex plays an aggravating role in inflammatory ocular surface disorders.

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Section: Introductionmentioning

confidence: 99%

Clinical and Immunological Responses in Ocular Demodecosis

2011

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“…Blefarit olgularında demodex yoğunluğunun arttı-ğını bildiren yayınlar bulunmaktadır. 8,[10][11][12]16 Çalış-mamızda blefaritli hastaların kirpiklerinde bulunan her iki türün yoğunluğu kontrol grubuna göre yük-sek bulunmuştur. DB ve DF görülme sıklığı ayrı ayrı değerlendirildiğinde blefaritlilerin kirpiklerinde DF görülme sıklığının artmış olmasına rağ-men, daha az rastlanan DB'in görülme sıklığındaki artışın daha yüksek oranda olduğu görülmektedir.…”

Section: Discussionunclassified

“…3 Hatta çok sayıda akar göz kapağı foliküllerine yerleşerek keratoz, hiperplazi ve melanosit toplanmasına yol açabilmektedir. [8][9][10][11] DF sayıları kaşlarda, kirpiklerde ve meibomian bezlerinde arttığında, blefarit bulgularına sebep olduğu söylenmiştir. 5 Blefarit olgularında yapılan çalışmalarda kirpiklerde saptanan DF sayısının kontrol gruplarına göre daha fazla olduğu bildirilmiş, kaşıntılı blefarit olgularında kaşıntının demodex'lerin yumurtlama dönemiyle paralellik gösterdiği saptanmıştır.…”

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“…5 Blefarit olgularında yapılan çalışmalarda kirpiklerde saptanan DF sayısının kontrol gruplarına göre daha fazla olduğu bildirilmiş, kaşıntılı blefarit olgularında kaşıntının demodex'lerin yumurtlama dönemiyle paralellik gösterdiği saptanmıştır. [8][9][10][11][12][13] Tanıda selofan bant, deri kazıntısı, punch biyopsisi ve standart yüzeyel deri biyopsisi (SYDB) gibi yöntemler kullanılmaktadır. Parazitin patojenitesinin saptanabilmesi için cm 2 'deki akar yoğunluğu önem taşımaktadır.…”

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What is the Importance of Demodex folliculorum and D. brevis in the Etiology of Blepharitis?

Yula¹,

Kaya²,

Atambay³

et al. 2013

Turkiye Klinikleri J Med Sci

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A An na ah ht ta ar r K Ke el li im me el le er r: : Blefarit; ektoparazitik infestasyonlar A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : It was reported that, Demodex folliculorum (DF) and D. brevis (DB) may cause an infestation in healthy subjects and, may be important for some eye problems such as blepharitis, or these parasites can bring the present disease into a more serious condition. In this study, we aimed to determine which demodex species' density increase in patients with blepharitis and whether the demodex density on face differs from healthy subjects. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : In the study, the presence of demodex species was analyzed on eyelashes and faces of 96 patients with blepharitis and 197 healthy subjects. Samples taken through standard superficial skin biopsy technique and eyelash epilation were analyzed with the light microscope. R Re es su ul lt ts s: : The mean age of the patients with blepharitis was 46.90±16.92 (15-89) years, whereas the mean age of control group was 39.54±17.61 (12-84) years. Among eyelash samples of the patients, 78 (81.25%) samples were found DF positive, whereas 25 (26.04%) of them were found DB positive; on the contrary 30 (15.22%) and 7 (3.55%) of the control group was DF and DB positive, respectively. Among the eyelash samples of the patients, the demodex incidence was statistically significantly higher compared to the control group (p<0.001). There was no significant difference in terms of demodex positivities on face. All patients who were demodex positive on the facial area were also found demodex positive for eyelash samples whereas 8 (24.2%) of eyelash samples were Demodex spp positive in the control group (p<0.001). C Co on nc cl lu us si io on n: : The results of our study underline that the presence of Demodex spp on facial area may be one the important factors in the pathogenesis of blepharitis. In conclusion, we suggest that taking the demodicosis presence into consideration as a worsening factor may help in the management of blepharitis.

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“…El 64% de nuestros pacientes era del sexo femenino; algunos autores atribuyen la predilección por el sexo femenino al uso de cosméticos 1,4 . Según varios estudios 22,31 , la infestación por Demodex sp está relacionada directamente conforme avanza la edad; la población en este trabajo es relativamente joven con una media de edad de 38 ± 13,5; el 61% tenía menos de 40 años, y probablemente sea la causa por la cual no se pudo demostrar asociación entre mayor edad y presencia de Demodex, además del tamaño pequeño de la muestra.…”

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