Demodex Folliculitis

Vu, John R.; English, Joseph C.

doi:10.1016/j.jpag.2011.03.008

Cited by 6 publications

(8 citation statements)

References 23 publications

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“…Demodex mites asymptomatically inhabit the pilosebaceous units of most adults (80%-100%), but an increased mite density (>5 mites/cm 2 ) may induce pityriasis folliculorum, pustular folliculitis, periorificial dermatitis, papulopustular rosacea, and papulopustular scalp eruptions (See Figure 2) [10,11]. Consequently, a Demodex mite infestation should be considered when a patient has refractory dermatologic eruptions.…”

Section: Demodicosismentioning

confidence: 99%

“…Consequently, a Demodex mite infestation should be considered when a patient has refractory dermatologic eruptions. Oral ivermectin is the treatment of choice for Demodex mites, but alternatives include oral metronidazole and topical formulations of sulfur, permethrin 5%, benzyl benzoate 10%, metronidazole 0.75%, ivermectin 1%, and crotamiton [7,[10][11][12].…”

Section: Demodicosismentioning

confidence: 99%

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Parasitic Diseases With Cutaneous Manifestations

Ash

Phillips

2016

North Carolina Medical Journal

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Parasitic diseases result in a significant global health burden. While often thought to be isolated to returning travelers, parasitic diseases can also be acquired locally in the United States. Therefore, clinicians must be aware of the cutaneous manifestations of parasitic diseases to allow for prompt recognition, effective management, and subsequent mitigation of complications. This commentary also reviews pharmacologic treatment options for several common diseases.

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Section: Demodicosismentioning

confidence: 99%

Section: Demodicosismentioning

confidence: 99%

Parasitic Diseases With Cutaneous Manifestations

Ash

Phillips

2016

North Carolina Medical Journal

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“…A study of 48 patients with rosacea revealed 5.7 times higher density of D. folliculorum colonization compared to healthy controls, indicating an association between the two conditions (Casas et al, ). However, causation has yet to be established (Bachmeyer & Moreno‐Sabater, ; Chen & Plewig, ; Cotliar & Frankfurt, ; Elston & Elston, ; Sabater‐Marco, Escutia‐Munoz, & Botella‐Estrada, ; Vu & English III, ; Yun, Levin, & Servat, ).…”

Section: Introductionmentioning

confidence: 99%

“…However, causation has yet to be established (Bachmeyer & Moreno-Sabater, 2017;Chen & Plewig, 2014;Cotliar & Frankfurt, 2013;Elston & Elston, 2014;Sabater-Marco, Escutia-Munoz, & Botella-Estrada, 2015;Vu & English III, 2011;Yun, Levin, & Servat, 2013).…”

mentioning

confidence: 99%

Treatment of Demodex ‐associated inflammatory skin conditions: A systematic review

Jacob

VanDaele

Brown

2019

Dermatologic Therapy

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Bacterial folliculitis, rosacea, and other common skin conditions have been linked to infestation by Demodex mites (human demodicosis). Currently, there is little guidance for treatment of inflammatory conditions associated with demodicosis. Thus, the objective of this review is to evaluate the efficacy and safety of treatments utilized for Demodex infestation. PubMed (1946 to January 2019) and Embase (1947 to January 2019) were searched with the following term combinations: Demodex mites, Demodex folliculitis, demodicosis, Demodex folliculorum, or Demodex brevis and articles evaluating treatment of body surface colonization with Demodex mites were included. Common interventions used for Demodex infestation include metronidazole‐based therapies, permethrin, benzoyl benzoate, crotamiton, lindane, and sulfur. Short courses of metronidazole taken orally have shown efficacy in reducing Demodex density. Additionally, topical administration of permethrin daily or twice daily was shown to be efficacious across multiple studies. Crotamiton and benzyl benzoate were also efficacious treatments. Several therapies were associated with mild‐to‐moderate skin irritation. Due to limited data, no standard of care can be identified at this time. Efficacious treatment options may include permethrin, crotamiton, benzyl benzoate, and oral metronidazole; however, long‐term efficacy has not been established.

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“…A high prevalence of Demodex (80–100%) by the age of 50 years is proposed [ 1 ], although few individuals develop symptoms. Demodex proliferation can result in a number of cutaneous disorders including pustular folliculitis, pityriasis folliculorum, and papulopustular and granulomatous rosacea [ 2 ]. Several factors may be implicated in the development of pathogenic forms, including increased density of the mite, immune system disorders such as HIV infection, and the use of corticosteroids.…”

Section: Introductionmentioning

confidence: 99%

Crusted Demodicosis in an Immunocompetent Pediatric Patient

Guerrero-González

Herz‐Ruelas

Gómez‐Flores

et al. 2014

Case Reports in Dermatological Medicine

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Demodicosis refers to the infestation by Demodex spp., a saprophytic mite of the pilosebaceous unit. Demodex proliferation can result in a number of cutaneous disorders including pustular folliculitis, pityriasis folliculorum, papulopustular, and granulomatous rosacea, among others. We report the case of a 7-year-old female presenting with pruritic grayish crusted lesions over her nose and cheeks, along with facial erythema, papules, and pustules. The father referred chronic use of topical steroids. A potassium hydroxide mount of a pustule scraping revealed several D. folliculorum mites. Oral ivermectin (200 μg/kg, single dose) plus topical permethrin 5% lotion applied for 3 consecutive nights were administered. Oral ivermectin was repeated every week and oral erythromycin plus topical metronidazole cream was added. The facial lesions greatly improved within the following 3 months. While infestation of the pilosebaceous unit by Demodex folliculorum mites is common, only few individuals present symptoms. Demodicosis can present as pruritic papules, pustules, plaques, and granulomatous facial lesions. To our knowledge, this is the first reported case of facial crusted demodicosis in an immunocompetent child. The development of symptoms in this patient could be secondary to local immunosuppression caused by the chronic use of topical steroids.

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Demodex Folliculitis

Cited by 6 publications

References 23 publications

Parasitic Diseases With Cutaneous Manifestations

Parasitic Diseases With Cutaneous Manifestations

Treatment of Demodex ‐associated inflammatory skin conditions: A systematic review

Crusted Demodicosis in an Immunocompetent Pediatric Patient

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