DeMISTifying Paneth Cell Maturation

Spatz, Lillian B.; Mills, Jason C.

doi:10.1016/j.jcmgh.2019.08.005

Cited by 1 publication

(1 citation statement)

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“…Notably, the small intestinal crypts bear Paneth cells that have been shown to play key roles in GIT function (Chung and Raffatellu, 2019). These cells contribute to the integrity and cellular activities of the small intestinal crypts (Srugo et al, 2019) through secretion of growth factors (Spatz and Mills, 2019). Additionally, they regulate the intestinal microflora and have chemosensory functions (Vaishnava et al, 2008;Roura et al, 2019) and influence gut cell differentiation and maturation (Sato et al, 2011;Mei et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Medicinal Plants, Phytochemicals, and Their Impacts on the Maturation of the Gastrointestinal Tract

et al. 2021

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The gastrointestinal tract (GIT) is the first point of contact for ingested substances and thus represents a direct interface with the external environment. Apart from food processing, this interface plays a significant role in immunity and contributes to the wellbeing of individuals through the brain-gut-microbiota axis. The transition of life from the in utero environment, to suckling and subsequent weaning has to be matched by phased development and maturation of the GIT; from an amniotic fluid occupancy during gestation, to the milk in the suckling state and ultimately solid food ingestion at weaning. This phased maturation of the GIT can be affected by intrinsic and extrinsic factors, including diet. Despite the increasing dietary inclusion of medicinal plants and phytochemicals for health benefits, a dearth of studies addresses their impact on gut maturation. In this review we focus on some recent findings mainly on the positive impact of medicinal plants and phytochemicals in inducing precocious maturation of the GIT, not only in humans but in pertinent animals. We also discuss Paneth cells as mediators and potential markers of GIT maturation.

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