Demetallation of coordination compounds of nickel with tetradentate ligands based on S-substituted isothiosemicarbazides

Aryl- and Heteroaryl-Thiosemicarbazone Derivatives and Their Metal Complexes: A Pharmacological Template

“…Thiosemicarbazone derivatives substituted with different aryl/heteroaryl rings other than pyridyl and isatin rings are also reported in the literature and exhibit significant pharmacological activities [68][69][70][71][72][73][74][75][76][77][78][79][80][81][82]. A novel class of -D-glucopyranosyl thiosemicarbazone derivative has inhibitory activity against glycogen phosphorylase b (GPb) ( Table 3) [68].…”

“…Cytotoxic evaluation of S-methyl derivatives of thiosemicarbazone (S-methyl N 1 ,N 4 -di(salicylidene) isothiosemicarbazones) were reported by several researchers [80,81], re-vealing that the 4-methoxy thiosemicarbazones-Fe chelates have considerable activity against K562 cell lines and 3methoxy thiosemicarbazones-nickel chelate exhibited a cytotoxic effect against ECV304 and K562 cell lines. These results revealed that the presence of methoxy groups on the aromatic ring increase the selectivity of the cytotoxicity [77,[80][81][82].…”

“…Copper complexes with bis-(thiosemicarbazone) ligands, were first synthesized in the 1950s, [104] and the bisthiosemicarbazones can bind in neutral as well as anionic S-Methyl N 1 ,N 4 -di(salicylidene) isothiosemicarbazones [77,80,81] forms using both of their arms. Recent studies on these copper complexes showed that they have anticancer, superoxide dismutase-like activity, which has been used as positron emission-imaging agents for blood perfusion and tissue hypoxia using radiolabelled complexes [105,106].…”

“…Antiviral activity was also observed against HIV in four bis(thiosemicarbazonate)gold(III) complexes [Au(L)]Cl such as glyoxal-bis-(N4-methylthiosemicarbazone), glyoxal-bis-(N4ethylthiosemicarbazone), diacetyl-bis-(N4-methylthiosemicarbazone) and diacetyl-bis-(N4-ethylthiosemicarbazone) [107]. Revenco et al has synthesized and characterized the coordination behavior of palladium and nickel complexes of S-methyl N 1 ,N 4 -di(salicylidene) isothiosemicarbazones [80,81]. They described that the ligand in different configurations using either O, N, and S or O, N, and N donor atoms for coordination, this coordinated complex enhances the reactivity of H2L molecules [109].…”