Dementia With Lewy Bodies

Zupancic, Melanie; Mahajan, Aman; Handa, Kamna

doi:10.4088/pcc.11r01190

Cited by 30 publications

(13 citation statements)

References 67 publications

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“…The most common types of dementia are AD-related dementia (approximately 50–80% of all dementia cases) (Qiu et al, 2009 ; Abbott, 2011 ), vascular dementia (approximately 20–30%) (Abbott, 2011 ; Iadecola, 2013 ), dementia with Lewy bodies (between 15 and 35% according to Zupancic et al, 2011 , or less than 5% according to Abbott, 2011 ) and the frontotemporal dementia (FTD), which is the fourth most frequent form of presenile dementia (between 5 and 10%) (Abbott, 2011 ; Table 1 ).…”

Section: Frequent Forms Of Dementiamentioning

confidence: 99%

“…Vascular dementia is a heterogeneous group of brain disorders associated with a cognitive impairment that is attributed to multifactorial cerebrovascular pathologies, such as hypoperfusion, oxidative stress, and inflammation (Iadecola, 2013 ). Dementia with Lewy bodies is characterized by the presence of α-synuclein aggregates in neurons and glial cells (Zupancic et al, 2011 ), and also associated with cholinergic as well as glutamate transmission deficiencies (Zupancic et al, 2011 ). It may also be concluded, that there is a great deal of overlap between the symptoms of different types of dementia (Abbott, 2011 ).…”

Section: Frequent Forms Of Dementiamentioning

confidence: 99%

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Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

Tewari

Stankiewicz

Mocan

et al. 2018

Front. Aging Neurosci.

110

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Dementia is a clinical syndrome wherein gradual decline of mental and cognitive capabilities of an afflicted person takes place. Dementia is associated with various risk factors and conditions such as insufficient cerebral blood supply, toxin exposure, mitochondrial dysfunction, oxidative damage, and often coexisting with some neurodegenerative disorders such as Alzheimer's disease (AD), Huntington's disease (HD), and Parkinson's disease (PD). Although there are well-established (semi-)synthetic drugs currently used for the management of AD and AD-associated dementia, most of them have several adverse effects. Thus, traditional medicine provides various plant-derived lead molecules that may be useful for further medical research. Herein we review the worldwide use of ethnomedicinal plants in dementia treatment. We have explored a number of recognized databases by using keywords and phrases such as “dementia”, “Alzheimer's,” “traditional medicine,” “ethnopharmacology,” “ethnobotany,” “herbs,” “medicinal plants” or other relevant terms, and summarized 90 medicinal plants that are traditionally used to treat dementia. Moreover, we highlight five medicinal plants or plant genera of prime importance and discuss the physiological effects, as well as the mechanism of action of their major bioactive compounds. Furthermore, the link between mitochondrial dysfunction and dementia is also discussed. We conclude that several drugs of plant origin may serve as promising therapeutics for the treatment of dementia, however, pivotal evidence for their therapeutic efficacy in advanced clinical studies is still lacking.

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Section: Frequent Forms Of Dementiamentioning

confidence: 99%

Section: Frequent Forms Of Dementiamentioning

confidence: 99%

Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

Tewari

Stankiewicz

Mocan

et al. 2018

Front. Aging Neurosci.

110

View full text Add to dashboard Cite

show abstract

“…Lewy body dementias, the third most common type of dementia, results from the excessive accumulation of alpha‐synuclein protein, called Lewy bodies, in neurons. 34 LBD leads to cognitive impairments with recurrent visual hallucinations, lethargy, and a decrease in attention, as well as parkinsonism. 34 , 35 …”

Section: Dementiamentioning

confidence: 99%

Lipocalin 2 regulates iron homeostasis, neuroinflammation, and insulin resistance in the brains of patients with dementia: Evidence from the current literature

2021

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Dementia accompanied by memory loss is considered one of the most common neurodegenerative diseases worldwide, and its prevalence is gradually increasing. Known risk factors for dementia include genetic background, certain lifestyle and dietary patterns, smoking, iron overload, insulin resistance, and impaired glucose metabolism in the brain. Here, we review recent evidence on the regulatory role of lipocalin 2 (LCN2) in dementia from various perspectives. LCN2 is a neutrophil gelatinase‐associated protein that influences diverse cellular processes, including the immune system, iron homeostasis, lipid metabolism, and inflammatory responses. Although its functions within the peripheral system are most widely recognized, recent findings have revealed links between LCN2 and central nervous system diseases, as well as novel roles for LCN2 in neurons and glia. Furthermore, LCN2 may modulate diverse pathological mechanisms involved in dementia. Taken together, LCN2 is a promising therapeutic target with which to address the neuropathology of dementia.

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“…DLB is considered to be the second most common form of neurodegenerative disorders after AD (Geser et al, 2005;Zupancic et al, 2011), affecting as many as 100,000 people in the UK and up to 1.3 million in the USA. Prevalence estimates range from 0% to 5% in the general population, and up to 30.5% of all dementia cases (Zaccai et al, 2005), and these are largely influenced by the clinical criteria used for DLB diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Molecular imaging biomarkers for dementia with Lewy bodies: an update

Mukaetova‐Ladinska

2014

Int. Psychogeriatr.

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Most of the above nuclear imaging methods are restricted to highly specialized clinical centers, and thus not applicable to a large number of patients requiring dementia (e.g. DLB) diagnosis in routine clinical setting. Validating them against more readily accessible peripheral biomarkers, e.g. CSF and blood biomarkers linked to the DLB process, may facilitate their use in wider clinical settings.

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Dementia With Lewy Bodies

Cited by 30 publications

References 67 publications

Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

Ethnopharmacological Approaches for Dementia Therapy and Significance of Natural Products and Herbal Drugs

Lipocalin 2 regulates iron homeostasis, neuroinflammation, and insulin resistance in the brains of patients with dementia: Evidence from the current literature

Molecular imaging biomarkers for dementia with Lewy bodies: an update

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