Dementia with Lewy bodies: a review

Rampello, Liborio; Cerasa, S.; Alvano, Alessandro; Buttà, V.; Raffaele, R; Vecchio, Ignazio; Cavallaro, Tiziana; Cimino, Elisa; Incognito, T.; Nicoletti, F

doi:10.1016/j.archger.2003.11.003

Cited by 21 publications

(8 citation statements)

References 66 publications

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“…In dementia with Lewy bodies, there is a reduction of presynaptic dopamine transporters seen in DaT scan that can differentiate it from Alzheimer's disease. However, our patients lacked the consensus criteria for dementia with Lewy bodies [18,19] . In HMPAO SPECT, they showed bilateral prefrontal and temporal hypoperfusion without any significant reduction in the parietal, posterior cingulate and occipital (Brodmann areas no.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Dopaminergic Function in Frontotemporal Dementia Using <sup>123</sup>I-FP-CIT Single Photon Emission Computed Tomography

et al. 2007

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Extrapyramidal symptoms are observed in frontotemporal dementia (FTD). ¹²³I-FP-CIT (DaT scan) single photon emission computed tomography (SPECT) can detect loss of presynaptic dopamine transporters in the striatum. We aimed to evaluate the dopaminergic status of the striatum in patients with FTD using DaT scan. Seven patients (age range 65–76 years), who fulfilled the Neary criteria and in whom the diagnosis of FTD was confirmed by hexamethylpropyleneamine oxime SPECT, were included in the study. The severity of the extrapyramidal symptoms was evaluated by the motor part of the Unified Parkinson’s Disease Rating Scale (UPDRS). SPECT using ¹²³I-FP-CIT was done. A (region – occipital)/occipital ratio was calculated for the striatum, putamen and caudate nucleus. The results were compared with those of the 7 age-matched normal controls. The uptake of the radiotracer in the right and left striatum was reduced to 62% (p = 0.000) and 68% (p = 0.000), respectively, compared to controls. The motor UPDRS score of the patients with FTD showed a negative correlation to the uptake of the radiotracer. The presynaptic dopamine transporter in FTD is impaired, related to the severity of the extrapyramidal symptoms. Since an effective treatment for FTD is still to be established, there is a need for evaluating the efficacy of dopaminergic drugs.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Dopaminergic Function in Frontotemporal Dementia Using <sup>123</sup>I-FP-CIT Single Photon Emission Computed Tomography

et al. 2007

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“…Consequently, AChE attracted considerable attention as a potential therapeutic target (Fernandez et al, 2000; Erkinjuntti et al, 2004; Rampello et al, 2004; Maidment et al, 2005). Indeed, AChE inhibitors partially improve cognitive and functional symptoms, by increasing the synaptic ACh availability.…”

Section: Cholinergic Dysfunction In Alsmentioning

confidence: 99%

Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase

Campanari

García‐Ayllón

Ciura

et al. 2016

Front. Mol. Neurosci.

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Amyotrophic Lateral Sclerosis (ALS) is a highly debilitating disease caused by progressive degeneration of motorneurons (MNs). Due to the wide variety of genes and mutations identified in ALS, a highly varied etiology could ultimately converge to produce similar clinical symptoms. A major hypothesis in ALS research is the “distal axonopathy” with pathological changes occurring at the neuromuscular junction (NMJ), at very early stages of the disease, prior to MNs degeneration and onset of clinical symptoms. The NMJ is a highly specialized cholinergic synapse, allowing signaling between muscle and nerve necessary for skeletal muscle function. This nerve-muscle contact is characterized by the clustering of the collagen-tailed form of acetylcholinesterase (ColQ-AChE), together with other components of the extracellular matrix (ECM) and specific key molecules in the NMJ formation. Interestingly, in addition to their cholinergic role AChE is thought to play several “non-classical” roles that do not require catalytic function, most prominent among these is the facilitation of neurite growth, NMJ formation and survival. In all this context, abnormalities of AChE content have been found in plasma of ALS patients, in which AChE changes may reflect the neuromuscular disruption. We review these findings and particularly the evidences of changes of AChE at neuromuscular synapse in the pre-symptomatic stages of ALS.

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“…Multiple system atrophy (Wenning & Jellinger, 2005) and dementia with Lewy bodies (Rampello et al, 2004) are two other devastating a-synucleinopathies. Multiple system atrophy (Wenning & Jellinger, 2005) and dementia with Lewy bodies (Rampello et al, 2004) are two other devastating a-synucleinopathies.…”

Section: Dopamine and A-synmentioning

confidence: 99%

Î±-Synuclein, oxidative stress and apoptosis from the perspective of a yeast model of Parkinson's disease

Witt

Flower

2006

FEMS Yeast Research

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The neuronal protein alpha-synuclein (alpha-syn) has been suggested to be one of the factors linked to Parkinson's disease (PD). Several organisms, including the rat, mouse, worm, and fruit fly, are being used to study alpha-syn pathobiology. A new model organism was recently added to this armamentarium: the budding yeast Saccharomyces cerevisiae. The yeast system recapitulates many of the findings made with higher eukaryotes. For example, yeast cells expressing alpha-syn accumulate lipid droplets, have vacuolar/lysosomal defects, and exhibit markers of apoptosis, including the externalization of phosphatidylserine, the release of cytochrome c, and the accumulation of reactive oxygen species. This MiniReview focuses on the mechanisms by which alpha-syn induces oxidative stress and the mechanisms by which yeast cells respond to this stress. Three classes of therapeutics are discussed.

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Dementia with Lewy bodies: a review

Cited by 21 publications

References 66 publications

Evaluation of Dopaminergic Function in Frontotemporal Dementia Using <sup>123</sup>I-FP-CIT Single Photon Emission Computed Tomography

Evaluation of Dopaminergic Function in Frontotemporal Dementia Using <sup>123</sup>I-FP-CIT Single Photon Emission Computed Tomography

Neuromuscular Junction Impairment in Amyotrophic Lateral Sclerosis: Reassessing the Role of Acetylcholinesterase

Î±-Synuclein, oxidative stress and apoptosis from the perspective of a yeast model of Parkinson's disease

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