Dementia screening in elderly high-risk patients following heart failure decompensation may predict unfavorable long-term clinical outcomes

Stępień, Konrad; Furczyńska, Patrycja; Zalewska, Magdalena; Nowak, Karol; Włodarczyk, Aleksandra; Owsianka, Izabella; Skorek, Paweł; Zalewski, J; Nessler, Jadwiga

doi:10.23736/s2724-5683.20.05157-9

Cited by 4 publications

(4 citation statements)

References 31 publications

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“…Recent systematic review and meta-analysis showed that HF increases the risk of dementia and cognitive impairment by 60 % (6) with the risk ratio of dementia in the HF population equal to 1.28 (95% confi dence interval (CI) 1.15 to 1.43, I 2 = 70.0 %, p < 0.001) as compared with the non-HF group (7). Our recent fi ndings indicate that the screening diagnosis of dementia (SDD) in patients following HF decompensation was associated with the higher prevalence of re-hospitalization (hazard ratio (HR) 2.22, 95% CI 1.23-4.01, p=0.007) (8).…”

Section: Introductionmentioning

confidence: 81%

“…The cognitive function was assessed with the Adult Lifestyles and Function Interview telephone version of the Mini-Mental State Examination (ALFI-MMSE) (8,18). The translation into Polish followed by translation back into English was performed prior to the psychological and psychiatric consultations.…”

Section: Screening Psychiatric Evaluationmentioning

confidence: 99%

“…The pathophysiology and etiology of dementia in patients following HF decompensation is still not fully elucidated. Our previous fi ndings have shown that the lower result of the questionnaire score was correlated with a history of stroke or transient ischemic attack (β=−0.29, p < 0.001), peripheral arterial disease (β=−0.20, p=0.011) and lower glomerular fi ltration rate (β= 0.24, p = 0.009) (8) but there was no difference in terms of left ventricular (LV) ejection fraction between patients with and without a screening diagnosis of dementia. On the other hand, it was shown that reduced cerebral blood fl ow was associated with deteriorated LV ejection fraction (9,10) stimulates neurons degeneration in older adults (11).…”

Section: Introductionmentioning

confidence: 96%

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Screening diagnosis of dementia in patients following heart failure decompensation is associated with a higher relative wall thickness

Nowak¹,

Stępień²,

Furczyńska³

et al. 2022

BLL

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BACKGROUND: The usefulness of echocardiographic characteristics for dementia prediction in patients with heart failure decompensation (HFD) is not determined. Therefore, we sought to investigate the echocardiographic features of patients with HFD and screening diagnosis of dementia (SDD). METHODS: 139 patients aged over 65 years were hospitalized with the diagnosis of HFD. Clinical characteristics and echocardiographic characteristics were recorded during hospitalization. SDD was defi ned based on the result of ALFI-MMSE of < 17 points. RESULTS: Patients with SDD were older (p = 0.013), had thicker IVSd (p = 0.021), thicker PWd (p = 0.005) and had a higher RWT (0.40 vs 0.35, p = 0.004) than patients without SDD, without differences in LVMI (p = 0.13). There was no correlation between RWT and LVMI (r = −0.01, p = 0.88). In the multivariate analysis, an older age (β = −0.116, 95% CI −0.224 -−0.008, p = 0.035, per year) and a higher RWT (β =−0.069, 95% CI −0.137 -−0.002, p=0.045, per 0.01) infl uenced a lower ALFI-MMSE. For a prediction of SDD, the RWT reached the area under a ROC curve of 0.67 (95% CI 0.56-0.77, p = 0.004 with sensitivity of 60% and specifi city of 70% for RWT of ≥0.375). CONCLUSIONS: Apart from age, RWT refl ecting left ventricular geometry changes but not hypertrophy was independently but moderately associated with SDD in patients following HFD (Tab. 4, Fig. 1, Ref. 35).

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Section: Introductionmentioning

confidence: 81%

Section: Screening Psychiatric Evaluationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

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Screening diagnosis of dementia in patients following heart failure decompensation is associated with a higher relative wall thickness

Nowak¹,

Stępień²,

Furczyńska³

et al. 2022

BLL

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“…The proper order of interventions is difficult to determine because there are no clear indications as to whether MI or stroke should be treated first. However, every decision can impact the patient's health, including disability or heart failure in future (11)(12)(13).…”

Section: Spontaneous Co-occurrence Of MI and Stroke 24mentioning

confidence: 99%

Rare instances of concomitant acute myocardial infarction and stroke

MACIEJEWSKI,

NOWAK,

WAWAK

et al. 2024

BLL

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Cardio-cerebral infarction (CCI) is a term coined to describe concomitant myocardial infarction and acute ischemic stroke. Acute myocardial infarction and stroke, as separate events, constitute some of the most important causes for disability and mortality in aging societies. Stroke can either occur simultaneously with myocardial infarction or become a serious complication of myocardial infarction and/or its treatment. The frequency of CCI has been reported at a 0.009% incidence rate in stroke patients and is associated with an extremely high mortality. Because of the rare occurrence of CCI, there are currently no guidelines for assessing its diagnosis and optimal treatment. Therefore, currently, the management of CCI cases needs to be individualized. Hopefully, in the future, the results of large clinical trials or prospective registries are expected to enhance our understanding of managing concomitant acute MI and stroke. In this review we have focused on the current literacy in the diagnosis and treatment of CCIs. The paper illustrates potential distinct scenarios of CCI through the analysis of three patient cases (Fig. 5, Ref. 65).

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Clinical characteristics and long-term outcomes of patients with heart failure with improved ejection fraction. First Polish experience from LECRA-HF registry

Stępień,

Nowak,

Kachnic

et al. 2024

Advances in Medical Sciences

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Dementia screening in elderly high-risk patients following heart failure decompensation may predict unfavorable long-term clinical outcomes

Cited by 4 publications

References 31 publications

Screening diagnosis of dementia in patients following heart failure decompensation is associated with a higher relative wall thickness

Screening diagnosis of dementia in patients following heart failure decompensation is associated with a higher relative wall thickness

Rare instances of concomitant acute myocardial infarction and stroke

Clinical characteristics and long-term outcomes of patients with heart failure with improved ejection fraction. First Polish experience from LECRA-HF registry

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