Dementia Screening Accuracy is Robust to Premorbid IQ Variation: Evidence from the Addenbrooke’s Cognitive Examination-III and the Test of Premorbid Function

Stott, Joshua; Scior, Katrina; Mandy, William; Charlesworth, Georgina

doi:10.3233/jad-161218

Cited by 11 publications

(16 citation statements)

References 28 publications

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“…The sample is from the same cohort as that in a previously published paper, where eligibility criteria are outlined in detail (Stott et al, 2017c). In brief, the sample consisted of two groups: (i) 102 people with mild dementia (PLWD group) and (ii) 77 people aged over 65 without dementia (OA group).…”

Section: Samplementioning

confidence: 99%

Thought–feeling discrimination in people with dementia: adaptation and preliminary validation of the first dementia-specific measure

Stott

Cadman

Potts

et al. 2019

Int. Psychogeriatr.

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Objective:There is emerging evidence that cognitive behavioral therapy (CBT) can be effective for treating anxiety and depression in people living with dementia (PLWD). Discriminating between thoughts and feelings is a critical element of CBT and also of relevance to emotional understanding more generally. The aim of the present study was the structured adaptation and preliminary validation of an existing measure of thought–feeling discrimination for use in PLWD.Methods/Design:The Behavior Thought Feeling Questionnaire (BTFQ) was adapted via expert and service-user consultation for use in PLWD. One hundred two PLWD and 77 people aged over 65 years who did not have measurable cognitive impairments completed the adapted measure along with two measures of emotional recognition and reasoning. The factor structure of this measure was examined and the measure reduced.Results:Factor analysis suggested a two-factor solution with thought and feeling items loading on separate factors. The behavior items were not included in scoring due to high cross-loading and ceiling effects, leaving a 14-item measure with two subscales. Thus, an adapted measure was created (named the BTFQ-D), which showed moderate convergent validity in the PLWD but not the older adult sample. Both thought and feeling subscales showed good internal consistency.Conclusions:The BTFQ-D showed preliminary validity as a measure of thought–feeling discrimination in PLWD. It may have utility in measuring readiness for CBT as part of clinical assessment. Further validation is required.

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Section: Samplementioning

confidence: 99%

Thought–feeling discrimination in people with dementia: adaptation and preliminary validation of the first dementia-specific measure

Stott

Cadman

Potts

et al. 2019

Int. Psychogeriatr.

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“…Such a trend was also evident in other studies. 20,26,48 Another similar study 49 showed that in a younger age group (60-69 years) with higher educational attainment (>10 years of schooling), the majority of the population scored above 80 on the ACE-III. In contrast, a completely opposite trend was seen with the cut-off value below 80.…”

Section: Discussionmentioning

confidence: 94%

<p>Hindi Version of Addenbrooke’s Cognitive Examination III: Distinguishing Cognitive Impairment Among Older Indians at the Lower Cut-Offs</p>

Bajpai¹,

Upadhyay²,

Sati³

et al. 2020

CIA

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Background: Screening and diagnostic tests provide an objective measure of cognitive performance and also aid in distinguishing mild cognitive impairment (MCI) from major neurocognitive disorder (MNCD). Further, when such tests are culturally and educationally unbiased, it strengthens their diagnostic utility. This study aimed to validate the Hindi version of Addenbrooke's Cognitive Examination III (ACE-III) in Indian older adults and compare its validity with the Hindi Mini-Mental State Examination (HMSE). Methods: A sample of 412 consenting older adults visiting a memory clinic was recruited into the study. They were categorized into three groups: healthy controls (n=222), MCI (n=70), and MNCD (n=120). The complete clinical protocol was followed. Hindi ACE-III and HMSE were administered and were statistically analyzed. Results: The optimal cutoff values to detect MCI and MNCD with ACE-III were 71 and 62 (AUC: 0.849 and 0.884), respectively, which were slightly higher than with HMSE (AUC: 0.822, 0.861). Education-and age-stratified cutoffs were also computed. Conclusion: Hindi ACE-III has good discriminating power at lower cutoffs than the standard scores in differentiating between MCI and MNCD.

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“…The sample for validation analyses is from the same cohort as that in a previously published paper, where eligibility criteria are outlined in detail . In brief, the sample consisted of two groups: (a) 102 people with mild dementia (PLWD group) and (b) 77 people aged over 65 without dementia (OA group).…”

Section: Methodsmentioning

confidence: 99%

Cognitive mediation in people with dementia: Development, structural, and construct validity of the first dementia‐specific measure

Stott

Cadman²,

Scior

et al. 2019

Int J Geriat Psychiatry

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Objectives Anxiety and depression are common and deleterious comorbidities in people living with dementia (PLWD). Cognitive behavioural therapy (CBT) is one of the few promising treatments; however, it is unclear whether PLWD have the necessary prerequisites to engage in this. Having an understanding of cognitive mediation, that a thought mediates the relationship between an antecedent event and its emotional consequence, is key for engaging with CBT and is also a critical component of emotion regulation. There are no measures of this construct validated for PLWD. This study aims to adapt and validate an existing measure for this population. A secondary aim is to assess its applicability in older adults (OA) without a recognised neurocognitive impairment. Methods A measure of cognitive mediation was adapted via expert and service user consultation for use in PLWD. A total of 102 PLWD and 77 OA without neurocognitive impairments completed the adapted measure along with two measures of emotion recognition and reasoning. Factor structure was examined separately in both samples, and the measure reduced, with convergent validity assessed. Results A final measure of 10 items (named the CM‐Dem) was subject to factor analysis yielding a single factor solution. The measure showed good psychometric properties in PLWD, including good model fit, high internal consistency, inter‐rater reliability, and moderate convergent validity with related constructs. In contrast, poor validity was found in OA, especially a lack of convergent validity. Conclusions The CM‐Dem has clinical and research utility as a measure of cognitive mediation in PLWD, but less so in OA.

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Dementia Screening Accuracy is Robust to Premorbid IQ Variation: Evidence from the Addenbrooke’s Cognitive Examination-III and the Test of Premorbid Function

Abstract: Background: Scores on cognitive screening tools for dementia are associated with

Cited by 11 publications

References 28 publications

Thought–feeling discrimination in people with dementia: adaptation and preliminary validation of the first dementia-specific measure

Thought–feeling discrimination in people with dementia: adaptation and preliminary validation of the first dementia-specific measure

<p>Hindi Version of Addenbrooke’s Cognitive Examination III: Distinguishing Cognitive Impairment Among Older Indians at the Lower Cut-Offs</p>

Cognitive mediation in people with dementia: Development, structural, and construct validity of the first dementia‐specific measure

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