Dementia of frontal lobe type.

Neary, David; Snowden, Julie S.; Northen, B; Goulding, Peter

doi:10.1136/jnnp.51.3.353

Cited by 550 publications

(264 citation statements)

References 19 publications

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“…frontal type," owing to the neuropsychological characteristics of that condition that suggest im paired function of frontal regions of the brain (Neary et al, 1988). Similar patients have been de scribed previously (Gustafson, 1987), and necropsy studies have confirmed the absence of Alzheimer's pathology and demonstrated in some cases the pathological changes of Pick's disease (Brun, 1987).…”

supporting

confidence: 53%

The Use of [^99mTc]-HM-PAO in the Diagnosis of Primary Degenerative Dementia

Testa

Snowden

Neary

et al. 1988

J Cereb Blood Flow Metab

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Summary:The clinical value of single photon emission computed tomography (SPECT) in the differential diag nosis of dementia due to cerebral atrophy was evaluated by comparing the pattern of distribution [99mTc]_ HM-PAO in three dementing conditions, Imaging was carried out in 26 patients with suspected Alzheimer's dis ease, 14 with dementia of the frontal-lobe type, and 13 with progressive supranuclear palsy, Images were evalu ated and reported without knowledge of clinical diagnosis with respect to regions of reduced uptake of tracer. Re-

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supporting

confidence: 53%

The Use of [^99mTc]-HM-PAO in the Diagnosis of Primary Degenerative Dementia

Testa

Snowden

Neary

et al. 1988

J Cereb Blood Flow Metab

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“…Presenting features are insidious and include progressive changes in the patient's personality, interpersonal conduct, and emotional modulation (Gustafson 1987;Neary et al 1988;Piguet et al 2011a). A variable degree of language impairment is also present.…”

Section: The Concept Of Frontotemporal Dementia: Historical Overviewmentioning

confidence: 99%

“…Cases of Pick's disease with argyrophilic inclusions and ballooned neurons (type A) were now distinguished from those with ballooned neurons lacking argyrophilic inclusions (type B) and those lacking both ballooned neurons and argyrophilic inclusions (type C) (Constantinidis 1974). Work by Brun, Gustafson, and Neary showed that some individuals with frontal lobe atrophy lacked a distinctive histopathology (Brun 1987;Gustafson 1987;Neary et al 1988). Clinically, these patients suffered from a severe personality disorder, which is now known as behavioralvariant FTD (bvFTD).…”

Section: The Concept Of Frontotemporal Dementia: Historical Overviewmentioning

confidence: 99%

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

Goedert¹,

Ghetti²,

Spillantini³

2011

Cold Spring Harbor Perspectives in Medicine

137

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“…A diagnosis of progressive cortical frontoparietal gliosis associated with presenile dementia was made in a female patient according to Neary et al 14 . Neuropsychological assessment was made on the basis of Mini-Mental State Examination (MMSE) 15 , Clinical Dementia Rating (CDR) 16 .…”

Section: Methodsmentioning

confidence: 99%

Frontoparietal cortical atrophy with gliosis in the gray matter of cerebral cortex: case report

Brito-Marques

Mello

Montenegro

2002

Arq. Neuro-Psiquiatr.

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-The case of a patient who suffered from progressive amnesia, depressive humor, language and visuospatial disturbances, and hallucination episodies with interference at the daily living activities is reported. She had moderate neuropsichological diffuse deficits at the first examination, especially at the executive and visuo-constructive functions. Her cerebrospinal fluid test presented high total protein. Magnetic resonance image showed slight white matter increase in periventricular, semi-oval center bilateral and left external capsule regions, besides light frontal and parietal lobe atrophy, bilaterally. Brain single photon emission computerized tomography revealed both a bilateral moderate frontal and a severe parietal lobe hypoperfusion, especially on the left side. Macroscopic examination showed cortical atrophy, severe on the frontal, moderate on the parietal and mild on the posterior third temporal lobes, bilaterally. There was a slight atrophy on the neostriatum in the basal ganglia. The histopathological findings of the autopsy showed severe neuronal loss with intensive gemioscytic gliosis and variable degrees of status spongiosus in cortical layer. Hematoxylineosin and Bielschowsky staining did not show neuronal swelling (balooned cell), argyrophilic inclusion (Pick's bodies), neurofibrillary tangles nor senile plaques. Immunohistochemical staining for anti-ubiquitin, anti-tau, anti-β-amyloide, and anti-prion protein were tested negative.KEY WORDS: presenile dementia, cortical gliosis, diffuse neuronal loss, spongiosis, inespecific cortical atrophy.Atrofia cortical frontoparietal com gliose na substância cinzenta do córtex cerebral: relato de caso Atrofia cortical frontoparietal com gliose na substância cinzenta do córtex cerebral: relato de caso Atrofia cortical frontoparietal com gliose na substância cinzenta do córtex cerebral: relato de caso Atrofia cortical frontoparietal com gliose na substância cinzenta do córtex cerebral: relato de caso Atrofia cortical frontoparietal com gliose na substância cinzenta do córtex cerebral: relato de caso RESUMO -É descrito o caso de uma paciente que apresentava amnésia, humor deprimido, distúrbio de linguagem e visoespacial, e alucinação visual com evolução progressiva, interferindo nas atividades de vida diária. Na primeira avaliação neuropsicológica havia déficit difuso de intensidade moderada, especialmente nas funções executivas e viso-construtivas. O exame de líquido céfalo-raqueano mostrou a taxa de proteína elevada. Ressonância magnética evidenciou leve hiperintensidade de sinal na região periventricular, centro semi-oval bilateral, e alta hiperintensidade de sinal na região da cápsula interna esquerda, além de leve atrofia bilateral nos lobos frontoparietais. Tomografia cerebral por emissão de fóton único revelou hipoperfusão de intensidade moderada nos lobos frontais e severa nos parietais, especialmente à esquerda. Os achados de necrópsia evidenciaram atrofia cortical, sendo severa nos lobos frontais, moderada nos parietais e leve no terço pos...

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Dementia of frontal lobe type.

Cited by 550 publications

References 19 publications

The Use of [^99mTc]-HM-PAO in the Diagnosis of Primary Degenerative Dementia

The Use of [^99mTc]-HM-PAO in the Diagnosis of Primary Degenerative Dementia

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

Frontoparietal cortical atrophy with gliosis in the gray matter of cerebral cortex: case report

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Dementia of frontal lobe type.

Cited by 550 publications

References 19 publications

The Use of [99mTc]-HM-PAO in the Diagnosis of Primary Degenerative Dementia

The Use of [99mTc]-HM-PAO in the Diagnosis of Primary Degenerative Dementia

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

Frontoparietal cortical atrophy with gliosis in the gray matter of cerebral cortex: case report

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Product

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The Use of [^99mTc]-HM-PAO in the Diagnosis of Primary Degenerative Dementia

The Use of [^99mTc]-HM-PAO in the Diagnosis of Primary Degenerative Dementia