Dementia in Parkinson's disease

Tison, François; Dartigues, J.-F.; Auriacombe, Sophie; Letenneur, Luc; Boller, François; Alpérovitch, A

doi:10.1212/wnl.45.4.705

Cited by 76 publications

(49 citation statements)

References 14 publications

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“…It is well known that poor mood stimulates the eating of "comfort foods" such as chocolate and that depression increases craving for sweets [8]. As expected from several previous reports [14], the frequency and severity of depression were significantly higher in our PD population compared to the control group with a frequency similar to other studies using self-questionnaires [12,13]. However, statistical analysis showed no influence of both BDI-1 score and frequency of depression on chocolate consumption in the two study groups.…”

Section: Discussionsupporting

confidence: 88%

Chocolate consumption is increased in Parkinson’s disease

et al. 2009

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Clinical observations in Parkinson's disease (PD) patients suggested an increased chocolate consumption. Chocolate contains high contents of various biogenic amines potentially influencing brain monoamine metabolism. 498 PD patients and their partners were evaluated by a structured self-questionnaire asking for consumption of chocolate and non-chocolate sweets, changes in chocolate consumption during the disease course, and depressive symptoms. Questionnaires from 274 patients (55 %) and 234 controls were eligible for further analysis. Consumption of chocolate was significantly higher in PD patients compared to controls, while consumption of non-chocolate sweets was similar in both groups. Our study suggests that chocolate consumption is increased in PD independent of concomitant depressive symptoms measured by BDI-1. Although reasons for increased chocolate consumption in PD remain elusive, it may hypothetically be a consequence of the high content of various biogenic amines and/or caffeine analogues with potential antiparkinsonian effects.

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Section: Discussionsupporting

confidence: 88%

Chocolate consumption is increased in Parkinson’s disease

et al. 2009

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“…A relationship between motor severity [25][26][27][28][29] and depression [26,30,31] has been demonstrated in other studies of dementia in PD. Depression is common in PD [32,33] and it is possible that depression may coexist with dementia rather than exert a negative effect upon it.…”

Section: Discussionmentioning

confidence: 59%

The detection of dementia and cognitive impairment in a community population of elderly people with Parkinson's disease by use of the CAMCOG neuropsychological test

Hobson¹

1999

Age and Ageing

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Aim: to assess cognitive function in elderly subjects with clinically probable Parkinson's disease (PD). Methods: a community sample of 126 patients with probable PD completed the CAMCOG, which is the cognitive section of the Cambridge Examination for Mental Disorders, and the Mini-Mental State Examination (MMSE). The performance of the CAMCOG and the MMSE in detecting dementia in this subject group was compared with the results of applying the DSM-IV criteria for dementia to this population. Results: A total of 44% of the group met DSM-IV criteria for dementia, which is higher than most previous prevalence figures for dementia in PD. The CAMCOG was more sensitive than the MMSE in detecting cognitive impairment and more specific than the MMSE in detecting dementia as defined by DSM-IV criteria. Poorer performance on the CAMCOG was related to gender, social class and age (P < 0.05). Among subjects with PD, those with dementia, as defined by DSM-IV criteria, were significantly older, had greater depressive symptomatology and had greater motor deficits. A greater proportion of the group with dementia were living in residential care (P < 0.05). Conclusion:The CAMCOG appears to be a useful screening instrument for dementia and cognitive impairment in PD. Furthermore, it may prove helpful in detecting those with PD who may be at risk of developing dementia and in longitudinal studies of cognitive function in PD.

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“…Among the 2,792 subjects recruited, 66 were excluded from the study because of dementia, as defined by DSM-IIIR criteria (3), and nine because of other causes of parkinsonism: three had drug-induced parkinsonism, five had "vascular" parkinsonism, and one had probable multiple-system atrophy. Five patients had both dementia and parkinsonism.…”

Section: Resultsmentioning

confidence: 99%

Dependency in parkinson's disease: A population‐based survey in nondemented elderly subjects

et al. 1997

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Little epidemiological data are available on the dependency status of elderly patients with Parkinson's disease (PD) living in the community. This study assessed the activities of daily living (ADL), the instrumental activities of daily living (IADL), and mobility in a representative sample of elderly nondemented PD subjects (n = 20), compared to a control population (n = 2,697). We found a significantly higher level of dependency in the PD sample based on ADL, IADL, and mobility scales. Half of the PD subjects were dependent for ADL (versus 13.2% for controls), 80% were dependent for IADL (versus 28% for controls), and 20% had their mobility restricted to their home (versus 1.5% for controls). The proportion of PD patients tended to be higher in those more depressed or with more severe motor symptoms. PD patients were not found to be more isolated socially or from family than was the control group and, in any case, dependency seemed not to be associated with isolation. When adjusting for age, sex, depressive symptoms, Mini Mental Status examination score, and dyspnea, PD remained significantly associated with dependency. PD thus constitutes a significant factor of dependency in elderly subjects living at home. Institutionalization occurred over four times more frequently in the PD group than in the general population, but no specific factor of institutionalization was noted.

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Dementia in Parkinson's disease

Cited by 76 publications

References 14 publications

Chocolate consumption is increased in Parkinson’s disease

Chocolate consumption is increased in Parkinson’s disease

The detection of dementia and cognitive impairment in a community population of elderly people with Parkinson's disease by use of the CAMCOG neuropsychological test

Dependency in parkinson's disease: A population‐based survey in nondemented elderly subjects

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