Dementia in Parkinson?s disease: diffusion tensor imaging

Matsui, Hirokazu; Nishinaka, Kazuto; Oda, Masaya; Niikawa, Hidekazu; Kubori, Tamotsu; Udaka, Fukashi

doi:10.1111/j.1600-0404.2007.00838.x

Cited by 85 publications

(63 citation statements)

References 28 publications

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“…Five studies found reductions in the frontal white matter, 4 significant. 9,11,21,26 Measures of diffusivity were less frequently reported, and often no significant overall differences were detected.…”

Section: Resultsmentioning

confidence: 99%

“…Nonmotor symptoms can be particularly problematic in PD, with up to 80% of older patients eventually developing associated dementia. 53 A study 9 comparing PDD with PD detected bilateral posterior cingulate FA reduction in PDD, an interesting finding suggesting that the posterior cingulate may have an important role in dementias associated with Lewy bodies but one that requires further verification and direct comparison with Alzheimer disease for which this is also an early area of change. 54 LBDs, PDD, and LBD share common clinical and neurobiological features.…”

Section: Resultsmentioning

confidence: 99%

“…LBD vs controls comparison had somewhat mixed findings, ranging from local alterations in the inferior longitudinal fasciculus or parietal lobe to widespread reductions in FA. One study, comparing PDD with PD, 9 found significantly reduced FA bilaterally in the posterior cingulum in patients with PDD. PDD and LBD were compared in 1 identified study.…”

Section: Resultsmentioning

confidence: 99%

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Diffusion tensor imaging in parkinsonian syndromes

2013

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Objectives: We performed a systematic review to assess alterations in measures of diffusion tensor imaging (DTI) in parkinsonian syndromes, exploring the potential role of DTI in diagnosis and as a candidate biomarker. Methods:We searched EMBASE and Medline databases for DTI studies comparing parkinsonian syndromes or related dementias with controls or another defined parkinsonian syndrome. Key details for each study regarding participants, imaging methods, and results were extracted. Estimates were pooled, where appropriate, by random-effects meta-analysis. Results:Of 333 results, we identified 43 studies suitable for inclusion (958 patients, 764 controls). DTI measures detected alterations in all parkinsonian syndromes, with distribution varying differentially with disease type. Nine studies were included in a meta-analysis of the substantia nigra in Parkinson disease. A notable effect size was found for lowered fractional anisotropy in the substantia nigra for patients with Parkinson disease vs controls (20.639, 95% confidence interval 20.860 to 20.417, p , 0.0001).Conclusion: DTI may be a promising biomarker in parkinsonian syndromes and have a future role in differential diagnosis. Larger cohort studies are required to investigate some encouraging preliminary findings. Given the complexity of the parkinsonian syndromes, it is likely that any potential DTI biomarker would be used in combination with other relevant biomarkers. Differences in natural history and therapy options make early and accurate diagnosis of parkinsonian syndromes important. 1 Emission tomography (SPECT or PET) has a role but it can be expensive, with limited availability, and requires radioactive tracers. 2 There is particular interest in the potential of advanced structural MRI techniques to differentiate among parkinsonian syndromes and to offer candidate biomarkers, facilitating early or premanifest diagnosis and monitoring of disease progression.Diffusion tensor imaging (DTI) is an MRI technique assessing the orientation and integrity of white matter tracts in vivo by measuring the diffusion of water molecules in neural fibers 3 and it also shows promise for studying gray matter areas. It estimates both the degree of directionality using anisotropy (frequently fractional anisotropy [FA]) and the overall movement of molecules (mean diffusivity [MD]; trace; apparent diffusion coefficient [ADC]). These measurements can either be extracted locally in predefined regions using region of interest (ROI) analysis or tractography or, alternatively, globally using voxel-based analysis (VBA) or tract-based spatial statistics (TBSS). Disruptions to microstructural tissue integrity, such as those found in the neurodegeneration of parkinsonian syndromes can be associated with alterations in anisotropy and diffusivity measures. 3 We therefore performed a systematic review of the literature to assess

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Diffusion tensor imaging in parkinsonian syndromes

2013

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“…10 Changes in FA have also been found in the frontal lobes, including the supplementary motor area, the presupplementary motor area, and the cingulum, in patients with PD without dementia relative to controls by using statistical parametric mapping analysis in conjunction with diffusion tensor imaging. 11 In a diffusion tensor imaging study of subjects with PDD (n ϭ 11), Matsui et al 12 reported a reduction in the FA in the posterior cingulate compared with the FA in subjects with PD (n ϭ 26) and healthy controls (n ϭ 10). These findings support the notion that the posterior cingulate may play an im-portant role in the pathologic process of PDD.…”

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confidence: 99%

“…Almost all studies of diffusion tensor imaging in PD have used either ROI diffusion tensor imaging 10,12 or statistical parametric mapping methods. 11 Diffusion tensor tractography is one of the most promising imaging processing techniques because it enables both visualization of the fiber pathways in the brain and quantitative analysis of specific fiber bundles.…”

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confidence: 99%

White Matter Alteration of the Cingulum in Parkinson Disease with and without Dementia: Evaluation by Diffusion Tensor Tract–Specific Analysis

Kamagata¹,

Motoi²,

Abe³

et al. 2012

AJNR Am J Neuroradiol

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Neurocognitive and psychiatric disorders‐related axonal degeneration in Parkinson's disease

Andica

Kamagata

Hatano

et al. 2020

J of Neuroscience Research

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Neurocognitive and psychiatric disorders have significant consequences for quality of life in patients with Parkinson's disease (PD). In the current study, we evaluated microstructural white matter (WM) alterations associated with neurocognitive and psychiatric disorders in PD using neurite orientation dispersion and density imaging (NODDI) and linked independent component analysis (LICA). The indices of NODDI were compared between 20 and 19 patients with PD with and without neurocognitive and psychiatric disorders, respectively, and 25 healthy controls using tract‐based spatial statistics and tract‐of‐interest analyses. LICA was applied to model inter‐subject variability across measures. A widespread reduction in axonal density (indexed by intracellular volume fraction [ICVF]) was demonstrated in PD patients with and without neurocognitive and psychiatric disorders, as compared with healthy controls. Compared with patients without neurocognitive and psychiatric disorders, patients with neurocognitive and psychiatric disorders exhibited more extensive (posterior predominant) decreases in axonal density. Using LICA, ICVF demonstrated the highest contribution (59% weight) to the main effects of diagnosis that reflected widespread decreases in axonal density. These findings suggest that axonal loss is a major factor underlying WM pathology related to neurocognitive and psychiatric disorders in PD, whereas patients with neurocognitive and psychiatric disorders had broader axonal pathology, as compared with those without. LICA suggested that the ICVF can be used as a useful biomarker of microstructural changes in the WM related to neurocognitive and psychiatric disorders in PD.

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Dementia in Parkinson?s disease: diffusion tensor imaging

Abstract: Our results showed that the posterior cingulate areas play some important roles in the dementing process in PDD. However, as the pathological processes responsible for dementia in PD patients may be multifaceted, further studies are necessary.

Cited by 85 publications

References 28 publications

Diffusion tensor imaging in parkinsonian syndromes

Diffusion tensor imaging in parkinsonian syndromes

White Matter Alteration of the Cingulum in Parkinson Disease with and without Dementia: Evaluation by Diffusion Tensor Tract–Specific Analysis

Neurocognitive and psychiatric disorders‐related axonal degeneration in Parkinson's disease

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