Dementia and Major Neurocognitive Disorders: Some Lessons Learned One Century after the first Alois Alzheimer’s Clinical Notes

Петретто, Донателла Рита; Carrogu, Gian Pietro; Gaviano, Luca; Pili, Lorenzo; Пили, Роберто

doi:10.3390/geriatrics6010005

Cited by 1 publication

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“…NCDs were included in the Fifth Edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5), which distinguished between mild and major forms [2]. It was hoped that the term “major NCD” would be viewed as less stigmatizing than “dementia” while the inclusion of criteria for a milder form of acquired cognitive decline would provide opportunities for earlier detection, advance care planning, and treatment before the condition progresses to a severe stage [3]. Major NCDs are marked by significant cognitive decline that results in impairments of activities of daily living, which are not better explained by delirium or another mental health disorder.…”

Section: Introductionmentioning

confidence: 99%

Potentially Modifiable Risk Factors for Dementia and Mild Cognitive Impairment: An Umbrella Review and Meta-Analysis

Jones,

Ali,

Kenny

et al. 2024

Dement Geriatr Cogn Disord

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Introduction The prevalence of mild and major neurocognitive disorders (NCDs), also referred to as mild cognitive impairment and dementia, is rising globally. The prevention of NCDs is a major global public health interest. We sought to synthesize the literature on potentially modifiable risk factors for NCDs. Methods We conducted an umbrella review using a systematic search across multiple databases to identify relevant systematic reviews and meta-analyses. Eligible reviews examined potentially modifiable risk factors for mild or major NCDs. We used a random effects multi-level meta-analytic approach to synthesize risk ratios for each risk factor while accounting for overlap in the reviews. We further examined risk factors for major NCD due to two common etiologies: Alzheimer’s disease and vascular dementia. Results A total of 45 reviews with 212 meta-analyses were synthesized. We identified fourteen broadly defined modifiable risk factors that were significantly associated with these disorders: alcohol consumption, body weight, depression, diabetes mellitus, diet, hypertension, less education, physical inactivity, sensory loss, sleep disturbance, smoking, social isolation, traumatic brain injury, and vitamin D deficiency. All 14 factors were associated with the risk of major NCD, and five were associated with mild NCD. We found considerably less research for vascular dementia and mild NCD. Conclusion Our review quantifies the risk associated with 14 potentially modifiable risk factors for mild and major NCDs, including several factors infrequently included in dementia action plans. Prevention strategies should consider approaches that reduce the incidence and severity of these risk factors through health promotion, identification, and early management.

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Section: Introductionmentioning

confidence: 99%

Potentially Modifiable Risk Factors for Dementia and Mild Cognitive Impairment: An Umbrella Review and Meta-Analysis

Jones,

Ali,

Kenny

et al. 2024

Dement Geriatr Cogn Disord

View full text Add to dashboard Cite

show abstract

Dementia and Major Neurocognitive Disorders: Some Lessons Learned One Century after the first Alois Alzheimer’s Clinical Notes

Abstract: Over 100 years ago, Alois Alzheimer presented the clinical signs and symptoms of what has been later called “Alzheimer Dementia” in a young woman whose name was Augustine Deter [...]

Cited by 1 publication

References 63 publications

Potentially Modifiable Risk Factors for Dementia and Mild Cognitive Impairment: An Umbrella Review and Meta-Analysis

Potentially Modifiable Risk Factors for Dementia and Mild Cognitive Impairment: An Umbrella Review and Meta-Analysis

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