Dementia: An Evidence-Based Review of Common Presentations and Family-Based Interventions

Buffington, Angela L.H.; Lipski, Dorothy M.; Westfall, Erin

doi:10.7556/jaoa.2013.046

Cited by 16 publications

(11 citation statements)

References 27 publications

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“…Increases in the number of older people require social, economic, and medical changes, including measures of dementia. Dementia is a clinical syndrome that involves progressive deterioration of intellectual function, such as memory, executive functioning, and language [ 4 ]. Dementia covers a wide range of symptoms of disease and has subtypes, Alzheimer’s disease [ 5 ], vascular dementia [ 6 ], mixed dementia [ 7 ], dementia with Lewy bodies [ 8 ], and frontotemporal dementia [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Educational benefits for nurses and nursing students of the dementia supporter training program in Japan

et al. 2018

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In Japan, which is thought to be a rapidly growing super-aging society, a national campaign named “the Dementia Supporter Caravan” has been deployed. The aim of this study was to assess the educational benefits of the dementia supporter training program for nurses and nursing students. We conducted dementia supporter training, and measured knowledge and attitudes regarding people with dementia as educational benefits pre- and post-training. Data sets of 134 nursing students and 63 nurses were analyzed. The results indicated that the two groups gained knowledge, understanding, and the confidence to care for people with dementia after attending the dementia supporter training program. Moreover, the two groups derived different benefits from the program. Nursing students gained substantial knowledge and learnt the importance of early detection and treatment, to levels similar to those of nurses prior to training. The training program reduced the difficulties of nurses to interact with and care for people with dementia. We can conclude that the dementia supporter training program has considerable educational benefits for nurses and nursing students.

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Section: Introductionmentioning

confidence: 99%

Educational benefits for nurses and nursing students of the dementia supporter training program in Japan

et al. 2018

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“…Due to the advances in health care and social services provided by modern and industrial countries for their citizens, the average life span has increased with significant rises in elderly populations. This results in an expected increase in old-age diseases, mainly dementia [1,2]. The prevalence of dementia among the elderly population has not only increased in modern and advanced countries but in developing countries as well [3].…”

Section: Introductionmentioning

confidence: 99%

Sesame Oil-Based Nanostructured Lipid Carriers of Nicergoline, Intranasal Delivery System for Brain Targeting of Synergistic Cerebrovascular Protection

Abourehab

Khames

Genedy³

et al. 2021

Pharmaceutics

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Nicergoline (NIC) is a semisynthetic ergot alkaloid derivative applied for treatment of dementia and other cerebrovascular disorders. The efficacy of sesame oil to slow and reverse the symptoms of neurodegenerative cognitive disorders has been proven. This work aimed to formulate and optimize sesame oil-based NIC-nanostructured lipid carriers (NIC–NLCs) for intranasal (IN) delivery with expected synergistic and augmented neuroprotective properties. The NIC–NLC were prepared using sesame oil as a liquid lipid. A three-level, three-factor Box–Behnken design was applied to statistically optimize the effect of sesame oil (%) of the total lipid, surfactant concentration, and sonication time on particle size, zeta potential, and entrapment efficacy as responses. Solid-state characterization, release profile, and ex vivo nasal permeation in comparison to NIC solution (NIC–SOL) was studied. In vivo bioavailability from optimized NIC–NLC and NIC–SOL following IN and IV administration was evaluated and compared. The optimized NIC–NLC formula showed an average particle size of 111.18 nm, zeta potential of −15.4 mV, 95.11% entrapment efficacy (%), and 4.6% loading capacity. The NIC–NLC formula showed a biphasic, extended-release profile (72% after 48 h). Permeation of the NIC–NLC formula showed a 2.3 enhancement ratio. Bioavailability studies showed a 1.67 and 4.57 fold increase in plasma and brain following IN administration. The results also indicated efficient direct nose-to-brain targeting properties with the brain-targeting efficiency (BTE%) and direct transport percentage (DTP%) of 187.3% and 56.6%, respectively, after IN administration. Thus, sesame oil-based NIC–NLC can be considered as a promising IN delivery system for direct and efficient brain targeting with improved bioavailability and expected augmented neuroprotective action for the treatment of dementia.

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“…As the older adult population in the United States increases, it is expected that primary care physicians will be confronted with and challenged by the complexities of treating these patients. 20 Physicians must be knowledgeable about and consider the benefits and risks associated with antipsychotic use in older patients with dementia when making decisions on how to best manage the symptoms.…”

Section: National Initiatives To Reduce Antipsychotic Use Among Oldermentioning

confidence: 99%

Reducing Off-Label Antipsychotic Use in Older Community-Dwelling Adults With Dementia: A Narrative Review

Bain¹,

Schwartz²,

Chan-Ting³

2017

Journal of Osteopathic Medicine

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The off-label use of antipsychotics for the management of behavioral and psychologic symptoms of dementia (BPSD) in older adults (age ≥65 years) is common, despite evidence of modest benefits and serious risks. Although national initiatives aimed at reducing antipsychotic use among older adults with BPSD in nursing homes have been successful, similar initiatives are lacking for community-dwelling adults with dementia. As a result, older adults with BPSD residing in the community may be at an even greater risk of being negatively affected by antipsychotic use. Physicians should be knowledgeable of this issue and understand the alternatives to antipsychotics, as well as how to reduce antipsychotic use in patients with dementia who are already taking antipsychotics.

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Dementia: An Evidence-Based Review of Common Presentations and Family-Based Interventions

Cited by 16 publications

References 27 publications

Educational benefits for nurses and nursing students of the dementia supporter training program in Japan

Educational benefits for nurses and nursing students of the dementia supporter training program in Japan

Sesame Oil-Based Nanostructured Lipid Carriers of Nicergoline, Intranasal Delivery System for Brain Targeting of Synergistic Cerebrovascular Protection

Reducing Off-Label Antipsychotic Use in Older Community-Dwelling Adults With Dementia: A Narrative Review

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